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    TRIM61 tripartite motif containing 61 [ Homo sapiens (human) ]

    Gene ID: 391712, updated on 3-Apr-2024

    Summary

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    Official Symbol
    TRIM61provided by HGNC
    Official Full Name
    tripartite motif containing 61provided by HGNC
    Primary source
    HGNC:HGNC:24339
    See related
    Ensembl:ENSG00000183439 MIM:619417; AllianceGenome:HGNC:24339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF35
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 4.2), thyroid (RPKM 2.0) and 17 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    4q32.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (164954446..164977657, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (168302109..168325338, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (165875598..165898809, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NACA family member 3, pseudogene Neighboring gene tripartite motif-containing protein 60-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22112 Neighboring gene family with sequence similarity 218 member A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:165912150-165912843 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:165916505-165917374 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:165917390-165918172 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:165918173-165918953 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:165922487-165923241 Neighboring gene tripartite motif-containing 75 pseudogene Neighboring gene ribosomal protein L21 pseudogene 51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Negative transcriptional modulation and silencing of the bi-exonic Rnf35 gene in the preimplantation embryo. Binding of the CCAAT-displacement protein/Cux to the untranslated exon 1 sequence. Huang CJ, et al. J Biol Chem, 2005 Sep 2. PMID 15994318
    2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. Comuzzie AG, et al. PLoS One, 2012. PMID 23251661, Free PMC Article
    3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
    4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ60274, MGC102996

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative tripartite motif-containing protein 61
    Names
    ring finger protein 35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012414.3 → NP_001012414.1  putative tripartite motif-containing protein 61 isoform 2

      See identical proteins and their annotated locations for NP_001012414.1

      Status: VALIDATED

      Source sequence(s)
      BC089393, CN311322
      Consensus CDS
      CCDS34093.1
      UniProtKB/Swiss-Prot
      Q5EBN2
      Related
      ENSP00000332288.5, ENST00000329314.6
      Conserved Domains (1) summary
      cd16607
      Location:13 → 59
      RING-HC_TRIM60_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM60, TRIM61 and similar proteins

    2. NM_001414904.1 → NP_001401833.1  putative tripartite motif-containing protein 61 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC106872
      UniProtKB/TrEMBL
      A0A494C0U7
      Related
      ENSP00000518164.1, ENST00000710271.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      164954446..164977657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      168302109..168325338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349976.1 → XP_054205951.1  putative tripartite motif-containing protein 61 isoform X1

      UniProtKB/TrEMBL
      A0A494C0U7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5EBN2.1 GenPept UniProtKB/Swiss-Prot:Q5EBN2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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