Homer1 homer scaffolding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Homer1provided by MGI
Official Full Name: homer scaffolding protein 1provided by MGI
Primary source: MGI:MGI:1347345
See related: Ensembl:ENSMUSG00000007617 AllianceGenome:MGI:1347345
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SYN47; Ves-1; vesl-1; homer-1; PSD-Zip45
Summary: Predicted to enable several functions, including scaffold protein binding activity; transmembrane transporter binding activity; and type 5 metabotropic glutamate receptor binding activity. Predicted to be a structural constituent of postsynapse. Involved in regulation of ion transport and regulation of postsynaptic neurotransmitter receptor activity. Acts upstream of or within several processes, including behavioral response to cocaine; chemical homeostasis within a tissue; and skeletal muscle fiber development. Located in several cellular components, including apical part of cell; myofibril; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human HOMER1 (homer scaffold protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 6.9), frontal lobe adult (RPKM 5.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C3; 13 47.83 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (93440265..93549471)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (93303757..93405129)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Homer1 ameliorates ischemic stroke by inhibiting necroptosis-induced neuronal damage and neuroinflammation.
Title: Homer1 ameliorates ischemic stroke by inhibiting necroptosis-induced neuronal damage and neuroinflammation.
Homer1 Protects against Retinal Ganglion Cell Pyroptosis by Inhibiting Endoplasmic Reticulum Stress-Associated TXNIP/NLRP3 Inflammasome Activation after Middle Cerebral Artery Occlusion-Induced Retinal Ischemia.
Title: Homer1 Protects against Retinal Ganglion Cell Pyroptosis by Inhibiting Endoplasmic Reticulum Stress-Associated TXNIP/NLRP3 Inflammasome Activation after Middle Cerebral Artery Occlusion-Induced Retinal Ischemia.
Arc and Homer1 are involved in comorbid epilepsy and depression: A microarray data analysis.
Title: Arc and Homer1 are involved in comorbid epilepsy and depression: A microarray data analysis.
Activity dependent dissociation of the Homer1 interactome.
Title: Activity dependent dissociation of the Homer1 interactome.
Homer1 promotes the conversion of A1 astrocytes to A2 astrocytes and improves the recovery of transgenic mice after intracerebral hemorrhage.
Title: Homer1 promotes the conversion of A1 astrocytes to A2 astrocytes and improves the recovery of transgenic mice after intracerebral hemorrhage.
Reciprocal Homer1a and Homer2 Isoform Expression Is a Key Mechanism for Muscle Soleus Atrophy in Spaceflown Mice.
Title: Reciprocal Homer1a and Homer2 Isoform Expression Is a Key Mechanism for Muscle Soleus Atrophy in Spaceflown Mice.
Gender-Dependent Deregulation of Linear and Circular RNA Variants of HOMER1 in the Entorhinal Cortex of Alzheimer's Disease.
Title: Gender-Dependent Deregulation of Linear and Circular RNA Variants of HOMER1 in the Entorhinal Cortex of Alzheimer's Disease.
Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome.
Title: Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome.
The mTORC2 Regulator Homer1 Modulates Protein Levels and Sub-Cellular Localization of the CaSR in Osteoblast-Lineage Cells.
Title: The mTORC2 Regulator Homer1 Modulates Protein Levels and Sub-Cellular Localization of the CaSR in Osteoblast-Lineage Cells.
Transcriptional corepressor SIN3A regulates hippocampal synaptic plasticity via Homer1/mGluR5 signaling.
Title: Transcriptional corepressor SIN3A regulates hippocampal synaptic plasticity via Homer1/mGluR5 signaling.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237074

NoName (e-PCR)
- UniSTS:237075

02.MHAa89e2.seq (e-PCR)
- UniSTS:122688

Homer1 (e-PCR), detects polymorphism
- UniSTS:506984

AF093257 (e-PCR)
- UniSTS:163542

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of postsynapse	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables type 5 metabotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled glutamate receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within behavioral response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in protein tetramerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of store-operated calcium entry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in costamere	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
colocalizes_with excitatory synapse	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuron spine	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homer protein homolog 1

Names: VASP/Ena-related gene up-regulated during seizure and LTP 1; homer homolog 1; homer, neuronal immediate early gene, 1; immediate early gene protein Homer1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001284189.2 → NP_001271118.1 homer protein homolog 1 isoform b

See identical proteins and their annotated locations for NP_001271118.1

Status: VALIDATED

Description

Transcript Variant: This variant (b, also known as homer-1b) lacks an alternate in-frame exon in the central coding region, compared to variant L. The encoded isoform (b) is shorter than isoform L.

Source sequence(s)

AC154231, AF093258, AK137151, BY644449, CJ130737

Consensus CDS

CCDS70484.1

UniProtKB/Swiss-Prot

Q9Z2Y3

UniProtKB/TrEMBL

Q3UVL6

Related

ENSMUSP00000050471.5, ENSMUST00000060490.11

Conserved Domains (2) summary

COG1196
Location:157 → 352

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01206
Location:3 → 111

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
NM_001347598.1 → NP_001334527.1 homer protein homolog 1 isoform M

Status: VALIDATED

Description

Transcript Variant: This variant (M, also known as Vesl-1M) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant L. The encoded isoform (M) has a shorter and distinct C-terminus, compared to isoform L.

Source sequence(s)

AC120347, AK137151, BB448191, CJ130737, CJ133579

Consensus CDS

CCDS84048.1

UniProtKB/TrEMBL

Q3UVL6

Related

ENSMUSP00000105118.2, ENSMUST00000109492.9
NM_011982.4 → NP_036112.1 homer protein homolog 1 isoform S

See identical proteins and their annotated locations for NP_036112.1

Status: VALIDATED

Description

Transcript Variant: This variant (S, also known as homer-1a or Vesl-1S) lacks several 3' exons but contains a 3' terminal exon that extends past a splice site that is used in variant L, resulting in a novel 3' coding region and 3' UTR, compared to variant L. The encoded isoform (S) has a shorter and distinct C-terminus, compared to isoform L.

Source sequence(s)

AF093257, AK137151, BC064041, CJ130737

Consensus CDS

CCDS26687.1

UniProtKB/TrEMBL

D3Z6A8, Q5D052

Related

ENSMUSP00000099813.4, ENSMUST00000102752.10

Conserved Domains (1) summary

cd01206
Location:3 → 111

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
NM_147176.4 → NP_671705.2 homer protein homolog 1 isoform L

See identical proteins and their annotated locations for NP_671705.2

Status: VALIDATED

Description

Transcript Variant: This variant (L, also known as Vesl-1L) represents the longest transcript and encodes isoform L.

Source sequence(s)

AB019479, AC154231, AF093258, AK137151, BY644449, CJ130737

Consensus CDS

CCDS36745.1

UniProtKB/Swiss-Prot

Q8K3E1, Q8K4M8, Q9Z0E9, Q9Z216, Q9Z2Y3

Related

ENSMUSP00000079026.6, ENSMUST00000080127.12

Conserved Domains (2) summary

COG1196
Location:187 → 364

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01206
Location:3 → 111

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
NM_152134.3 → NP_687036.1 homer protein homolog 1 isoform d

See identical proteins and their annotated locations for NP_687036.1

Status: VALIDATED

Description

Transcript Variant: This variant (d, also known as homer-1d) uses an alternate 5'-terminal exon, initiates translation at an alternate start codon, and lacks an in-frame exon in the central coding region, compared to variant L. The encoded isoform (d) has a distinct N-terminus and is longer than isoform L.

Source sequence(s)

AC120347, AC154231, AF093258

Consensus CDS

CCDS36746.1

UniProtKB/Swiss-Prot

Q9Z2Y3

Related

ENSMUSP00000078093.7, ENSMUST00000079086.8

Conserved Domains (3) summary

cd01206
Location:19 → 127

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

cl12013
Location:206 → 349

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl19219
Location:264 → 334

DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

93440265..93549471

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158052.1 → XP_036013945.1 homer protein homolog 1 isoform X1

Conserved Domains (2) summary

COG1196
Location:203 → 380

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01206
Location:19 → 127

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
XM_036158053.1 → XP_036013946.1 homer protein homolog 1 isoform X2

Conserved Domains (1) summary

cd01206
Location:19 → 127

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain