Pex11a peroxisomal biogenesis factor 11 alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pex11aprovided by MGI
Official Full Name: peroxisomal biogenesis factor 11 alphaprovided by MGI
Primary source: MGI:MGI:1338788
See related: Ensembl:ENSMUSG00000030545 AllianceGenome:MGI:1338788
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PEX11alpha
Summary: Predicted to enable protein homodimerization activity. Acts upstream of or within brown fat cell differentiation. Predicted to be located in peroxisome. Predicted to be integral component of peroxisomal membrane. Predicted to be part of protein-containing complex. Predicted to be active in peroxisomal membrane. Orthologous to human PEX11A (peroxisomal biogenesis factor 11 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 11.5), liver adult (RPKM 10.0) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 45.12 cM; 7 D2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (79385705..79392879, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (79735957..79743131, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pex11a deficiency is associated with a reduced abundance of functional peroxisomes and aggravated renal interstitial lesions.
Title: Pex11a deficiency is associated with a reduced abundance of functional peroxisomes and aggravated renal interstitial lesions.
Pex11alpha deficiency impairs peroxisome elongation and abundance and peroxisomal fatty acid oxidation, which contributes to increased lipid accumulation in the liver.
Title: Pex11α deficiency impairs peroxisome elongation and division and contributes to nonalcoholic fatty liver in mice.
required for peroxisome proliferation in response to 4-phenylbutyrate but dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation
Title: PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

PMC134051P1 (e-PCR)
- UniSTS:270721

PMC321432P4 (e-PCR)
- UniSTS:273105

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in peroxisome fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in peroxisome fission	ISO Inferred from Sequence Orthology more info
involved_in peroxisome membrane biogenesis	ISO Inferred from Sequence Orthology more info
involved_in peroxisome organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of peroxisome size	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisomal membrane protein 11A

Names: PEX11-alpha; peroxin-11A; peroxisomal biogenesis factor 11a; protein PEX11 homolog alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011068.2 → NP_035198.1 peroxisomal membrane protein 11A

See identical proteins and their annotated locations for NP_035198.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the protein-coding transcript.

Source sequence(s)

AK076776, AK149387

Consensus CDS

CCDS21386.1

UniProtKB/Swiss-Prot

Q8C5B8, Q9Z211

UniProtKB/TrEMBL

Q3UER4

Related

ENSMUSP00000032761.8, ENSMUST00000032761.8

Conserved Domains (1) summary

pfam05648
Location:1 → 237

PEX11; Peroxisomal biogenesis factor 11 (PEX11)

RNA

NR_153403.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AK076776, AK078954

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

79385705..79392879 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152777.1 → XP_036008670.1 peroxisomal membrane protein 11A isoform X1

Conserved Domains (1) summary

pfam05648
Location:1 → 212

PEX11; Peroxisomal biogenesis factor 11 (PEX11)