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    Srsf12 serine and arginine-rich splicing factor 12 [ Mus musculus (house mouse) ]

    Gene ID: 272009, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Srsf12provided by MGI
    Official Full Name
    serine and arginine-rich splicing factor 12provided by MGI
    Primary source
    MGI:MGI:2661424
    See related
    Ensembl:ENSMUSG00000054679 AllianceGenome:MGI:2661424
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Srrp; Sfrs13b; Srsf13b; B830039L16
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA 5'-splice site recognition and regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be active in nuclear speck. Orthologous to human SRSF12 (serine and arginine rich splicing factor 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 9.0), whole brain E14.5 (RPKM 5.0) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srsf12 in Genome Data Viewer
    Location:
    4 A5; 4 14.73 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (33208991..33233344)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (33208991..33233343)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09882 Neighboring gene peptidase M20 domain containing 2 Neighboring gene predicted gene 11930 Neighboring gene STARR-positive B cell enhancer ABC_E9235 Neighboring gene STARR-positive B cell enhancer ABC_E6159 Neighboring gene STARR-seq mESC enhancer starr_09889 Neighboring gene STARR-seq mESC enhancer starr_09890 Neighboring gene proline-rich nuclear receptor coactivator 1 Neighboring gene STARR-seq mESC enhancer starr_09892 Neighboring gene STARR-positive B cell enhancer ABC_E833 Neighboring gene STARR-seq mESC enhancer starr_09894 Neighboring gene RNA guanylyltransferase and 5'-phosphatase Neighboring gene STARR-seq mESC enhancer starr_09895 Neighboring gene STARR-seq mESC enhancer starr_09897 Neighboring gene microRNA 8118

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. UPF2 is a critical regulator of liver development, function and regeneration. Thoren LA, et al. PLoS One, 2010 Jul 19. PMID 20657840, Free PMC Article
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA 5'-splice site recognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 12
    Names
    serine-arginine repressor protein
    serine/arginine-rich splicing factor 13B
    splicing factor, arginine/serine-rich 13B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356473.2 → NP_001343402.1  serine/arginine-rich splicing factor 12 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK046869, BB028293, BB871710
      Conserved Domains (1) summary
      cd12312
      Location:10 → 93
      RRM_SRSF10_SRSF12; RNA recognition motif in serine/arginine-rich splicing factor SRSF10, SRSF12 and similar proteins

    2. NM_001372518.1 → NP_001359447.1  serine/arginine-rich splicing factor 12 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK046869, BB028293, BB871710
      Consensus CDS
      CCDS89725.1
      UniProtKB/TrEMBL
      A3KG57
      Related
      ENSMUSP00000103794.2, ENSMUST00000108159.2
      Conserved Domains (1) summary
      cd12312
      Location:10 → 93
      RRM_SRSF10_SRSF12; RNA recognition motif in serine/arginine-rich splicing factor SRSF10, SRSF12 and similar proteins

    3. NM_001372519.1 → NP_001359448.1  serine/arginine-rich splicing factor 12 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK046869, AL670464, BB028293, BB646028

    4. NM_177774.5 → NP_808442.2  serine/arginine-rich splicing factor 12 isoform 2

      See identical proteins and their annotated locations for NP_808442.2

      Status: VALIDATED

      Source sequence(s)
      AK046869, AL670464, BB028293
      Consensus CDS
      CCDS18022.1
      UniProtKB/Swiss-Prot
      Q8C8K3
      Related
      ENSMUSP00000067939.2, ENSMUST00000067864.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      33208991..33233344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164170.1 → XP_036020063.1  serine/arginine-rich splicing factor 12 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C8K3.2 GenPept UniProtKB/Swiss-Prot:Q8C8K3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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