Tspo translocator protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tspoprovided by MGI
Official Full Name: translocator proteinprovided by MGI
Primary source: MGI:MGI:88222
See related: Ensembl:ENSMUSG00000041736 AllianceGenome:MGI:88222
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IBP; PBR; Bzrp; Tspo1
Summary: Enables transmembrane transporter binding activity. Involved in several processes, including negative regulation of autophagy of mitochondrion; negative regulation of protein ubiquitination; and protein localization to mitochondrion. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human TSPO (translocator protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal adult (RPKM 621.7), mammary gland adult (RPKM 396.5) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 39.4 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (83447774..83458404)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (83563573..83574203)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FGF1[DeltaHBS] ameliorates retinal inflammation via suppressing TSPO signal in a type 2 diabetes mouse model.
Title: FGF1(ΔHBS) ameliorates retinal inflammation via suppressing TSPO signal in a type 2 diabetes mouse model.
TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia.
Title: TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia.
Increased TSPO expression, pyroglutamate-modified amyloid beta (AbetaN3(pE)) accumulation and transient clustering of microglia in the thalamus of Tg-SwDI mice.
Title: Increased TSPO expression, pyroglutamate-modified amyloid beta (AβN3(pE)) accumulation and transient clustering of microglia in the thalamus of Tg-SwDI mice.
Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis.
Title: Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis.
Mitochondrial TSPO Promotes Hepatocellular Carcinoma Progression through Ferroptosis Inhibition and Immune Evasion.
Title: Mitochondrial TSPO Promotes Hepatocellular Carcinoma Progression through Ferroptosis Inhibition and Immune Evasion.
Effect of amphiphilic environment on the solution structure of mouse TSPO translocator protein.
Title: Effect of amphiphilic environment on the solution structure of mouse TSPO translocator protein.
ERK1/2-dependent TSPO overactivation associates with the loss of mitophagy and mitochondrial respiration in ALS.
Title: ERK1/2-dependent TSPO overactivation associates with the loss of mitophagy and mitochondrial respiration in ALS.
GENETIC DELETION OF TRANSLOCATOR PROTEIN EXACERBATES POST-SEPSIS SYNDROME WITH ACTIVATION OF THE C1Q PATHWAY IN SEPTIC MOUSE MODEL.
Title: GENETIC DELETION OF TRANSLOCATOR PROTEIN EXACERBATES POST-SEPSIS SYNDROME WITH ACTIVATION OF THE C1Q PATHWAY IN SEPTIC MOUSE MODEL.
Tracking Innate Immune Activation in a Mouse Model of Parkinson's Disease Using TREM1 and TSPO PET Tracers.
Title: Tracking Innate Immune Activation in a Mouse Model of Parkinson's Disease Using TREM1 and TSPO PET Tracers.
LncRNA MIAT impairs cardiac contractile function by acting on mitochondrial translocator protein TSPO in a mouse model of myocardial infarction.
Title: LncRNA MIAT impairs cardiac contractile function by acting on mitochondrial translocator protein TSPO in a mouse model of myocardial infarction.

Submit: New GeneRIF Correction See all GeneRIFs (85)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Gene trapped (1)
Targeted (10) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bzrp (e-PCR), detects polymorphism
- UniSTS:463360

Tspo (e-PCR), detects polymorphism
- UniSTS:528243

Tspo (e-PCR), detects polymorphism
- UniSTS:507292

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables androgen binding	ISO Inferred from Sequence Orthology more info
enables benzodiazepine receptor activity	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in behavioral response to pain	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in contact inhibition	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in maintenance of protein location in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ATP metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of corticosterone secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of programmed necrotic cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to acetylcholine	ISO Inferred from Sequence Orthology more info
involved_in steroid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: translocator protein

Names: PKBS; benzodiazepine receptor, peripheral; isoquinoline-binding protein; mitochondrial benzodiazepine receptor; peripheral-type benzodiazepine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.