Psme1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psme1provided by MGI
Official Full Name: proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)provided by MGI
Primary source: MGI:MGI:1096367
See related: Ensembl:ENSMUSG00000022216 AllianceGenome:MGI:1096367
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PA28a
Summary: Contributes to endopeptidase activator activity. Acts upstream of or within antigen processing and presentation of exogenous antigen. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human PSME1 (proteasome activator subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in large intestine adult (RPKM 93.4), liver E18 (RPKM 41.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55815951..55818984)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (55578494..55581527)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PA28alpha overexpressing female mice maintain exploratory behavior and capacity to prevent protein aggregation in hippocampus as they age.
Title: PA28α overexpressing female mice maintain exploratory behavior and capacity to prevent protein aggregation in hippocampus as they age.
Overexpression of PA28alpha and concomitant upregulation of PA28beta protein reduces depressive-like behavior and enhances learning and memory in female mice. The overexpression of PA28alpha does not increase PA28alphabeta-dependent proteasome activity but could still be linked to its protective functions upon oxidative stress and proteinopathy.
Title: PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity.
In mouse models of both genetic and dietary obesity, stimulation of proteasomal activity by exogenously expressing Nrf1 or by treatment with the proteasome activator PA28alpha in BAT resulted in improved insulin sensitivity. In conclusion, Nrf1 emerges as a novel guardian of brown adipocyte function, providing increased proteometabolic quality control for adapting to cold or to obesity.
Title: Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.
PA28a overexpression quadruples the number of surviving photoreceptors in the inferior retina of mice with inherited retinal degeneration.
Title: Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration.
Study clarifies the subunit composition and arrangement of PA28ab and provides key insights into the assembly of an asymmetric complex from two highly homologous subunits. Differential scanning fluorimetry experiments and activity assays classify PA28alpha4beta3 as most stable and most active, indicating that this assembly might represent the physiologically relevant species.
Title: The Mammalian Proteasome Activator PA28 Forms an Asymmetric α(4)β(3) Complex.
Inhibiting accumulation of PA28alpha using microRNA counteracted the removal of damaged proteins demonstrating that PA28alphabeta has a role required for resetting the levels of protein damage at the transition from self-renewal to cell differentiation.
Title: Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28.
this study performed biophysical and biochemical characterization of the structure and function of the PA28 hetero-oligomer.
Title: Spatial arrangement and functional role of α subunits of proteasome activator PA28 in hetero-oligomeric form.
Nrf2-dependent induction of proteasome and Pa28alphabeta regulator are required for adaptation to oxidative stress.
Title: Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress.
demonstrate that PA28 and the proteasome immunosubunits use fundamentally different mechanisms to enhance the supply of MHC class I-binding peptides
Title: PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo.
PA28alphaOE is sufficient to up-regulate 11S proteasomes, enhance proteasome-mediated removal of misfolded and oxidized proteins, and protect against oxidative stress in cardiomyocytes
Title: Enhancement of proteasome function by PA28α overexpression protects against oxidative stress.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:237187 (e-PCR)
- UniSTS:237187

Psme1 (e-PCR), detects polymorphism
- UniSTS:144281

AW413925 (e-PCR)
- UniSTS:180660

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to endopeptidase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within antigen processing and presentation of exogenous antigen	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of proteasomal protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome activator complex	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome activator complex subunit 1

Names: 11S regulator complex subunit alpha; PA28 alpha subunit; PA28alpha; REG-alpha; activator of multicatalytic protease subunit 1; protease (prosome, macropain) 28 subunit, alpha; proteasome (prosome, macropain) 28 subunit, alpha; proteasome activator 28 subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011189.1 → NP_035319.1 proteasome activator complex subunit 1

See identical proteins and their annotated locations for NP_035319.1

Status: PROVISIONAL

Source sequence(s)

D87909

Consensus CDS

CCDS36931.1

UniProtKB/Swiss-Prot

O35561, P97371, Q9D841

UniProtKB/TrEMBL

G3UXZ5, Q5HZK3

Related

ENSMUSP00000134735.2, ENSMUST00000174259.8

Conserved Domains (2) summary

pfam02251
Location:8 → 68

PA28_alpha; Proteasome activator pa28 alpha subunit

pfam02252
Location:104 → 246

PA28_beta; Proteasome activator pa28 beta subunit