GPR4 G protein-coupled receptor 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPR4provided by HGNC
Official Full Name: G protein-coupled receptor 4provided by HGNC
Primary source: HGNC:HGNC:4497
See related: Ensembl:ENSG00000177464 MIM:600551; AllianceGenome:HGNC:4497
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPR6C.l
Summary: Enables G protein-coupled receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of Rho protein signal transduction; and response to acidic pH. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in fat (RPKM 4.0), lung (RPKM 2.3) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.32

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (45589764..45602212, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (48417036..48429476, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (46093022..46105470, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis.
Title: The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis.
GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment.
Title: GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment.
Hypoxia-induced GPR4 suppresses trophoblast cell migration and proliferation through the MAPK signaling pathway.
Title: Hypoxia-induced GPR4 suppresses trophoblast cell migration and proliferation through the MAPK signaling pathway.
The evolution and mechanism of GPCR proton sensing.
Title: The evolution and mechanism of GPCR proton sensing.
Antagonism of GPR4 with NE 52-QQ57 and the Suppression of AGE-Induced Degradation of Type II Collagen in Human Chondrocytes.
Title: Antagonism of GPR4 with NE 52-QQ57 and the Suppression of AGE-Induced Degradation of Type II Collagen in Human Chondrocytes.
Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors.
Title: Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors.
The expression of GPR4 is upregulated in colorectal cancer and is associated with shorter overall survival time in CRC patients. These findings reveal the novel roles of GPR4 in CRC progression and suggest GPR4 might be a new therapeutic target for CRC treatment.
Title: Increased proton-sensing receptor GPR4 signalling promotes colorectal cancer progression by activating the hippo pathway.
Results indicate that GPR4 is expressed by multiple neuronal populations and endothelium and that its pH sensitivity is affected by level of expression and l-lactic acid (LL). GPR4 antagonist NE 52-QQ57 blunts hypercapnic response to CO2 but this effect is absent under anaesthesia, possibly due to the inhibitory effect of LL on GPR4.
Title: CNS distribution, signalling properties and central effects of G-protein coupled receptor 4.
Proton-sensing GPR4 signaling mediated the proton-induced inhibitory effects on the osteogenesis of BMSCs. YAP was the downstream effector of GPR4 signaling. Extracellular pH modulates the osteogenic responses of BMSCs by regulating the proton-sensing GPR4-YAP pathway.
Title: Decreased extracellular pH inhibits osteogenesis through proton-sensing GPR4-mediated suppression of yes-associated protein.
These results suggest that zOGR1, but not GPR4, is also a metal-sensing G-protein-coupled receptor in addition to a proton-sensing G-protein-coupled receptor, although not all metals that activate hOGR1 activated zOGR1.
Title: Manganese and cobalt activate zebrafish ovarian cancer G-protein-coupled receptor 1 but not GPR4.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

SGC35535 (e-PCR)
- UniSTS:31836

RH70611 (e-PCR)
- UniSTS:13439

SHGC-67307 (e-PCR)
- UniSTS:89991

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis involved in wound healing	IEA Inferred from Electronic Annotation more info
involved_in glomerular mesangial cell development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of vascular permeability	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to acidic pH	IDA Inferred from Direct Assay more info	PubMed
involved_in response to acidic pH	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: G-protein coupled receptor 4

Names: G-protein coupled receptor 19; G-protein coupled receptor 6C.l

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005282.3 → NP_005273.1 G-protein coupled receptor 4

See identical proteins and their annotated locations for NP_005273.1

Status: VALIDATED

Source sequence(s)

AC011480, BC038450, BE669939, DA858082

Consensus CDS

CCDS12669.1

UniProtKB/Swiss-Prot

A8K3T3, B0M0K1, P46093, Q6NWM4

Related

ENSP00000319744.3, ENST00000323040.5

Conserved Domains (1) summary

cd15366
Location:18 → 297

7tmA_GPR4; proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors