RGS5 regulator of G protein signaling 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RGS5provided by HGNC
Official Full Name: regulator of G protein signaling 5provided by HGNC
Primary source: HGNC:HGNC:10001
See related: Ensembl:ENSG00000143248 MIM:603276; AllianceGenome:HGNC:10001
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129
Summary: This locus represents naturally occurring readthrough transcription between the neighboring LOC127814295 (uncharacterized LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes on chromosome 1. Some variants of the readthrough transcript encode novel proteins with unique N-termini. [provided by RefSeq, Nov 2022]
Expression: Broad expression in adrenal (RPKM 143.5), thyroid (RPKM 96.0) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q23.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (163142299..163321735, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (162487178..162666666, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (163112089..163291525, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lnc-RGS5 sponges miR-542-5p to promote FoxM1/VEGFA signaling and breast cancer cell proliferation.
Title: Lnc‑RGS5 sponges miR‑542‑5p to promote FoxM1/VEGFA signaling and breast cancer cell proliferation.
RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes.
Title: RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes.
Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism.
Title: Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism.
Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma.
Title: Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma.
RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells.
Title: RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells.
RGS5 rs4657251 polymorphism is associated with small vessel occlusion stroke in Taiwan Han Chinese.
Title: RGS5 rs4657251 polymorphism is associated with small vessel occlusion stroke in Taiwan Han Chinese.
Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease.
Title: Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease.
Hepatic Regulator of G Protein Signaling 5 Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Transforming Growth Factor Beta-Activated Kinase 1-c-Jun-N-Terminal Kinase/p38 Signaling.
Title: Hepatic Regulator of G Protein Signaling 5 Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Transforming Growth Factor Beta-Activated Kinase 1-c-Jun-N-Terminal Kinase/p38 Signaling.
Human cytomegalovirus promoting endothelial cell proliferation by targeting regulator of G-protein signaling 5 hypermethylation and downregulation.
Title: Human cytomegalovirus promoting endothelial cell proliferation by targeting regulator of G-protein signaling 5 hypermethylation and downregulation.
Expression and role of regulator of G-protein signaling 5 in squamous cell carcinoma of the tongue.
Title: Expression and role of regulator of G-protein signaling 5 in squamous cell carcinoma of the tongue.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Essential hypertension, genetic MedGen: CN305331 OMIM: 145500 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of liver enzymes in korean children. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-132622 (e-PCR)
- UniSTS:185372

RGS5_786 (e-PCR)
- UniSTS:277671

RH102889 (e-PCR)
- UniSTS:97223

RH64669 (e-PCR)
- UniSTS:40139

SHGC-36663 (e-PCR)
- UniSTS:5838

RGS5 (e-PCR)
- UniSTS:503778

RH69538 (e-PCR)
- UniSTS:15859

RGS5 (e-PCR)
- UniSTS:479732

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: regulator of G-protein signaling 5

Names: regulator of G-protein signalling 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_027731.2 RefSeqGene

Range

123876..184493

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001195303.3 → NP_001182232.1 regulator of G-protein signaling 5 isoform 2

See identical proteins and their annotated locations for NP_001182232.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two alternate exons in the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2, also known as RGS5s), which is localized almost exclusively to the cytosolic fraction, is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode isoform 2.

Source sequence(s)

AJ891044, AL157502, AL583850, BX537427, DA699380

Consensus CDS

CCDS55652.1

UniProtKB/Swiss-Prot

O15539

Related

ENSP00000432313.1, ENST00000527988.1

Conserved Domains (1) summary

cl02565
Location:1 → 70

RGS; Regulator of G protein signaling (RGS) domain superfamily
NM_001254748.2 → NP_001241677.1 regulator of G-protein signaling 5 isoform 2

See identical proteins and their annotated locations for NP_001241677.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2, also known as RGS5s), which is localized almost exclusively to the cytosolic fraction, is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode isoform 2.

Source sequence(s)

AL157502, AL583850, BP292867, BX537427

Consensus CDS

CCDS55652.1

UniProtKB/Swiss-Prot

O15539

Related

ENSP00000480891.1, ENST00000618415.4

Conserved Domains (1) summary

cl02565
Location:1 → 70

RGS; Regulator of G protein signaling (RGS) domain superfamily
NM_001254749.2 → NP_001241678.1 regulator of G-protein signaling 5 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1.

Source sequence(s)

AL157502, AL583850, BU172751, BX537427, DA699380

Consensus CDS

CCDS58041.1

UniProtKB/TrEMBL

B2RD05

Related

ENSP00000433001.1, ENST00000530507.5

Conserved Domains (1) summary

cd08717
Location:65 → 182

RGS_RGS5; Regulator of G protein signaling (RGS) domain found in the RGS5 protein
NM_001414472.1 → NP_001401401.1 regulator of G-protein signaling 5 isoform 5

Status: REVIEWED

Source sequence(s)

AL451063, AL499616, AL583850, AL592435
NM_001414473.1 → NP_001401402.1 regulator of G-protein signaling 5 isoform 5

Status: REVIEWED

Source sequence(s)

AL451063, AL499616, AL583850, AL592435
NM_001414474.1 → NP_001401403.1 regulator of G-protein signaling 5 isoform 5

Status: REVIEWED

Source sequence(s)

AL451063, AL499616, AL583850, AL592435
NM_001414475.1 → NP_001401404.1 regulator of G-protein signaling 5 isoform 5

Status: REVIEWED

Source sequence(s)

AL451063, AL499616, AL583850, AL592435
NM_001414476.1 → NP_001401405.1 regulator of G-protein signaling 5 isoform 4

Status: REVIEWED

Source sequence(s)

AL499616, AL583850, AL592435
NM_001414477.1 → NP_001401406.1 regulator of G-protein signaling 5 isoform 2

Status: REVIEWED

Source sequence(s)

AL499616, AL583850, AL592435
NM_001414478.1 → NP_001401407.1 regulator of G-protein signaling 5 isoform 2

Status: REVIEWED

Source sequence(s)

AL499616, AL583850, AL592435
NM_001414479.1 → NP_001401408.1 regulator of G-protein signaling 5 isoform 2

Status: REVIEWED

Source sequence(s)

AL499616, AL583850, AL592435
NM_003617.4 → NP_003608.1 regulator of G-protein signaling 5 isoform 1

See identical proteins and their annotated locations for NP_003608.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1 (also known as RGS5), which is present in both the membrane and cytosolic fractions.

Source sequence(s)

AL451063, AL583850, BC030059

Consensus CDS

CCDS1244.1

UniProtKB/Swiss-Prot

E9PMP5, O15539, Q53XA9, Q599J0

UniProtKB/TrEMBL

B2RD05

Related

ENSP00000319308.5, ENST00000313961.10

Conserved Domains (1) summary

cd08717
Location:65 → 178

RGS_RGS5; Regulator of G protein signaling (RGS) domain found in the RGS5 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

163142299..163321735 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

162487178..162666666 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_025226.1: Suppressed sequence

Description

NM_025226.1: This RefSeq was permanently suppressed because it is UTR sequence and contains the wrong CDS.