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    ANKRD35 ankyrin repeat domain 35 [ Homo sapiens (human) ]

    Gene ID: 148741, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ANKRD35provided by HGNC
    Official Full Name
    ankyrin repeat domain 35provided by HGNC
    Primary source
    HGNC:HGNC:26323
    See related
    Ensembl:ENSG00000198483 AllianceGenome:HGNC:26323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in skin (RPKM 27.5), esophagus (RPKM 8.5) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1q21.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (145866564..145885866, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (144983377..145002686, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145549209..145568522)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1613 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1614 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:145584188-145585387 Neighboring gene nudix hydrolase 17 Neighboring gene protein inhibitor of activated STAT 3 Neighboring gene microRNA 6736 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145562391-145562908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145556249-145557232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1267 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1268 Neighboring gene uncharacterized LOC107985593 Neighboring gene integrin subunit alpha 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib through the ANKRD35-MITD1-ANXA1 axis. Wang Y, et al. Oncogene, 2023 Mar. PMID 36732658
    2. Identifying chromosomal subpopulations based on their recombination histories advances the study of the genetic basis of phenotypic traits. Ruiz-Arenas C, et al. Genome Res, 2020 Dec. PMID 33203765, Free PMC Article
    3. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. Fernandez J, et al. J Biol Chem, 2015 Feb 20. PMID 25505242, Free PMC Article
    4. Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107411
    5. SR protein kinases promote splicing of nonconsensus introns. Lipp JJ, et al. Nat Struct Mol Biol, 2015 Aug. PMID 26167880

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identifying chromosomal subpopulations based on their recombination histories advances the study of the genetic basis of phenotypic traits.
      Title: Identifying chromosomal subpopulations based on their recombination histories advances the study of the genetic basis of phenotypic traits.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag The interaction of HIV-1 CA with human cellular ankyrin repeat domain 35 protein (ANKRD35) is identified by yeast two-hybrid screen PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: PIAS3

    Homology

    Clone Names

    • FLJ25124, MGC126667, MGC126669

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001280799.2 → NP_001267728.1  ankyrin repeat domain-containing protein 35 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC243547, AK294308, DA399526, HY327286
      Consensus CDS
      CCDS72868.1
      UniProtKB/TrEMBL
      B4DFX6, F6XZD3
      Related
      ENSP00000442671.2, ENST00000544626.2
      Conserved Domains (4) summary
      cd00204
      Location:24 → 136
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:34 → 126
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:8 → 41
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:29 → 60
      ANK; ANK repeat [structural motif]

    2. NM_144698.5 → NP_653299.4  ankyrin repeat domain-containing protein 35 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC243547, AK294308, BC101618, DA399526, HY327286
      Consensus CDS
      CCDS72867.1
      UniProtKB/Swiss-Prot
      A6NEU0, B4DL62, Q3MJ10, Q8N283, Q96LS3
      Related
      ENSP00000347802.4, ENST00000355594.9
      Conserved Domains (6) summary
      COG1340
      Location:676 → 968
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00204
      Location:81 → 206
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam05278
      Location:803 → 950
      PEARLI-4; Arabidopsis phospholipase-like protein (PEARLI 4)
      pfam12796
      Location:58 → 150
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:24 → 74
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:53 → 84
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      145866564..145885866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      144983377..145002686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N283.3 GenPept UniProtKB/Swiss-Prot:Q8N283

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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