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    CNOT6L CCR4-NOT transcription complex subunit 6 like [ Homo sapiens (human) ]

    Gene ID: 246175, updated on 3-Apr-2024

    Summary

    Official Symbol
    CNOT6Lprovided by HGNC
    Official Full Name
    CCR4-NOT transcription complex subunit 6 likeprovided by HGNC
    Primary source
    HGNC:HGNC:18042
    See related
    Ensembl:ENSG00000138767 MIM:618069; AllianceGenome:HGNC:18042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCR4b
    Summary
    Predicted to enable poly(A)-specific ribonuclease activity. Involved in positive regulation of cell population proliferation and positive regulation of cytoplasmic mRNA processing body assembly. Located in cytosol and nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lymph node (RPKM 12.1), spleen (RPKM 8.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    4q21.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (77713387..77820269, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (81054227..81161055, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (78634541..78741423, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 13 Neighboring gene uncharacterized LOC105377296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15505 Neighboring gene uncharacterized LOC105377297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:78691877-78692518 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15509 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21640 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:78781972-78782187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21642 Neighboring gene mitochondrial ribosomal protein L1 Neighboring gene uncharacterized LOC102724916 Neighboring gene serine and arginine rich splicing factor 10 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables poly(A)-specific ribonuclease activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of CCR4-NOT complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 6-like
    Names
    carbon catabolite repressor protein 4 homolog B
    NP_001273719.1
    NP_001351935.1
    NP_001351936.1
    NP_001374764.1
    NP_001374765.1
    NP_001374766.1
    NP_001374767.1
    NP_001374768.1
    NP_001374769.1
    NP_001374770.1
    NP_001374771.1
    NP_001374772.1
    NP_653172.2
    XP_011530108.1
    XP_011530109.1
    XP_011530110.1
    XP_011530111.1
    XP_047305918.1
    XP_047305919.1
    XP_054205474.1
    XP_054205475.1
    XP_054205476.1
    XP_054205477.1
    XP_054205478.1
    XP_054205479.1
    XP_054205480.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286790.2NP_001273719.1  CCR4-NOT transcription complex subunit 6-like isoform 1

      See identical proteins and their annotated locations for NP_001273719.1

      Status: VALIDATED

      Source sequence(s)
      AC104701, AK303417, AL133112
      UniProtKB/Swiss-Prot
      Q96LI5, Q9UF92
      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:191538
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:57183
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3857
      LRR_1; leucine-rich repeat [structural motif]
    2. NM_001365006.1NP_001351935.1  CCR4-NOT transcription complex subunit 6-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104701
      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:186541
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:5375
      LRR_RI; leucine-rich repeat [structural motif]
    3. NM_001365007.2NP_001351936.1  CCR4-NOT transcription complex subunit 6-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104701
      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:186541
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:5375
      LRR_RI; leucine-rich repeat [structural motif]
    4. NM_001387835.1NP_001374764.1  CCR4-NOT transcription complex subunit 6-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104701
      Consensus CDS
      CCDS93552.1
      UniProtKB/TrEMBL
      B4E0K8, H0Y9Z5
      Conserved Domains (3) summary
      cd10312
      Location:186533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
    5. NM_001387836.1NP_001374765.1  CCR4-NOT transcription complex subunit 6-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104701
      Consensus CDS
      CCDS93552.1
      UniProtKB/TrEMBL
      B4E0K8, H0Y9Z5
      Related
      ENSP00000425571.2, ENST00000512485.6
      Conserved Domains (3) summary
      cd10312
      Location:186533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
    6. NM_001387837.1NP_001374766.1  CCR4-NOT transcription complex subunit 6-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104701
      Consensus CDS
      CCDS93552.1
      UniProtKB/TrEMBL
      B4E0K8, H0Y9Z5
      Related
      ENSP00000497467.1, ENST00000649644.1
      Conserved Domains (3) summary
      cd10312
      Location:186533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
    7. NM_001387838.1NP_001374767.1  CCR4-NOT transcription complex subunit 6-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104701
      Consensus CDS
      CCDS93552.1
      UniProtKB/TrEMBL
      B4E0K8, H0Y9Z5
      Conserved Domains (3) summary
      cd10312
      Location:186533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
    8. NM_001387839.1NP_001374768.1  CCR4-NOT transcription complex subunit 6-like isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC104701
      Consensus CDS
      CCDS93553.1
      UniProtKB/TrEMBL
      H0Y9C1
      Conserved Domains (3) summary
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
      cl00490
      Location:186434
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    9. NM_001387840.1NP_001374769.1  CCR4-NOT transcription complex subunit 6-like isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC104701
      Consensus CDS
      CCDS93553.1
      UniProtKB/TrEMBL
      H0Y9C1
      Related
      ENSP00000423750.2, ENST00000515506.6
      Conserved Domains (3) summary
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
      cl00490
      Location:186434
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    10. NM_001387841.1NP_001374770.1  CCR4-NOT transcription complex subunit 6-like isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC104701
      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:191570
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:57183
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3857
      LRR_1; leucine-rich repeat [structural motif]
    11. NM_001387842.1NP_001374771.1  CCR4-NOT transcription complex subunit 6-like isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC104701
      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:252599
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:118244
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:99118
      LRR_1; leucine-rich repeat [structural motif]
    12. NM_001387843.1NP_001374772.1  CCR4-NOT transcription complex subunit 6-like isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC104701
      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:252599
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:118244
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:99118
      LRR_1; leucine-rich repeat [structural motif]
    13. NM_144571.3NP_653172.2  CCR4-NOT transcription complex subunit 6-like isoform 1

      See identical proteins and their annotated locations for NP_653172.2

      Status: VALIDATED

      Source sequence(s)
      AC104701, AL133112, DA043791, DB454180
      UniProtKB/Swiss-Prot
      Q96LI5, Q9UF92
      UniProtKB/TrEMBL
      B4E0K8
      Related
      ENSP00000424896.1, ENST00000504123.7
      Conserved Domains (3) summary
      cd10312
      Location:191538
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:57183
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3857
      LRR_1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      77713387..77820269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531809.2XP_011530111.1  CCR4-NOT transcription complex subunit 6-like isoform X4

      See identical proteins and their annotated locations for XP_011530111.1

      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:191546
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:57183
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:5880
      LRR_RI; leucine-rich repeat [structural motif]
    2. XM_011531807.4XP_011530109.1  CCR4-NOT transcription complex subunit 6-like isoform X2

      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (4) summary
      cd10312
      Location:230577
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      sd00033
      Location:97119
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:95135
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:95176
      LRR_8; Leucine rich repeat
    3. XM_011531806.4XP_011530108.1  CCR4-NOT transcription complex subunit 6-like isoform X1

      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (4) summary
      cd10312
      Location:230585
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      sd00033
      Location:97119
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:95135
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:95176
      LRR_8; Leucine rich repeat
    4. XM_011531808.3XP_011530110.1  CCR4-NOT transcription complex subunit 6-like isoform X3

      See identical proteins and their annotated locations for XP_011530110.1

      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:191546
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:57183
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:5880
      LRR_RI; leucine-rich repeat [structural motif]
    5. XM_047449963.1XP_047305919.1  CCR4-NOT transcription complex subunit 6-like isoform X6

      UniProtKB/TrEMBL
      H0Y9Z5
    6. XM_047449962.1XP_047305918.1  CCR4-NOT transcription complex subunit 6-like isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      81054227..81161055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349502.1XP_054205477.1  CCR4-NOT transcription complex subunit 6-like isoform X4

    2. XM_054349500.1XP_054205475.1  CCR4-NOT transcription complex subunit 6-like isoform X2

    3. XM_054349499.1XP_054205474.1  CCR4-NOT transcription complex subunit 6-like isoform X1

    4. XM_054349501.1XP_054205476.1  CCR4-NOT transcription complex subunit 6-like isoform X3

    5. XM_054349504.1XP_054205479.1  CCR4-NOT transcription complex subunit 6-like isoform X6

      UniProtKB/TrEMBL
      H0Y9Z5
    6. XM_054349505.1XP_054205480.1  CCR4-NOT transcription complex subunit 6-like isoform X6

      UniProtKB/TrEMBL
      H0Y9Z5
    7. XM_054349503.1XP_054205478.1  CCR4-NOT transcription complex subunit 6-like isoform X5