Ppp1r1b protein phosphatase 1, regulatory inhibitor subunit 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp1r1bprovided by MGI
Official Full Name: protein phosphatase 1, regulatory inhibitor subunit 1Bprovided by MGI
Primary source: MGI:MGI:94860
See related: Ensembl:ENSMUSG00000061718 AllianceGenome:MGI:94860
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Darpp32; DARPP-32
Summary: This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders in humans. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression: Biased expression in duodenum adult (RPKM 153.3), large intestine adult (RPKM 145.7) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 61.75 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (98239232..98248622)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (98348406..98357796)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mapping Chromatin Occupancy of Ppp1r1b-lncRNA Genome-Wide Using Chromatin Isolation by RNA Purification (ChIRP)-seq.
Title: Mapping Chromatin Occupancy of Ppp1r1b-lncRNA Genome-Wide Using Chromatin Isolation by RNA Purification (ChIRP)-seq.
PLPP/CIN-mediated DARPP-32 serine 97 dephosphorylation delays the seizure onset in response to kainic acid in the mouse hippocampus.
Title: PLPP/CIN-mediated DARPP-32 serine 97 dephosphorylation delays the seizure onset in response to kainic acid in the mouse hippocampus.
DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium.
Title: DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium.
Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B.
Title: Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B.
Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington's disease.
Title: Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington's disease.
These results point to Cdk5 in the nucleus accumbens as a critical contributor to depressive-like behaviors in Huntington's disease (HD) mice by altering DARPP-32/beta-adducin signaling and disrupting the dendritic spine cytoskeleton.
Title: Cyclin-Dependent Kinase 5 Dysfunction Contributes to Depressive-like Behaviors in Huntington's Disease by Altering the DARPP-32 Phosphorylation Status in the Nucleus Accumbens.
This study strongly suggests that inflammation-regulated DARPP-32 constitutes a key component of H. pylori-mediated gastric tumourigenesis.
Title: Helicobacter pylori-induced cell death is counteracted by NF-κB-mediated transcription of DARPP-32.
the results suggest that by inducing dephosphorylation of DARPP-32 at Ser-97 and altering its cytonuclear distribution, glutamate may counteract dopamine/D1 receptor/PKA signaling at multiple cellular levels.
Title: Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution.
Darpp32 interaction with beta-adducin may be the molecular pathway by which environmental changes may rapidly alter responsiveness of striatal neurons involved in the reward system.
Title: DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons.
Results show that Darpp-32 was expressed in normal mouse mammary tissue and in some breast tumors, whereas t-Darpp was found exclusively in mammry tumors.
Title: Darpp-32 and t-Darpp are differentially expressed in normal and malignant mouse mammary tissue.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D1 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables D2 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables D3 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables D4 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables D5 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase inhibitor activity	TAS Traceable Author Statement more info	PubMed
enables protein serine/threonine phosphatase inhibitor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within behavioral response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of female receptivity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of female receptivity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to amphetamine	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to amphetamine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cocaine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to morphine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nicotine	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual learning	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in dendritic spine head	ISO Inferred from Sequence Orthology more info
located_in dendritic spine neck	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 1B

Names: dopamine- and cAMP-regulated neuronal phosphoprotein

NP_001300899.1

EC 3.1.3.16

NP_659077.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313970.1 → NP_001300899.1 protein phosphatase 1 regulatory subunit 1B isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate exon in place of the first exon compared to variant 1.This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.

Source sequence(s)

AY640620, BU700812

Consensus CDS

CCDS83889.1

UniProtKB/Swiss-Prot

Q60829

Related

ENSMUSP00000123528.2, ENSMUST00000137634.2

Conserved Domains (1) summary

pfam05395
Location:1 → 71

DARPP-32; Protein phosphatase inhibitor 1/DARPP-32
NM_144828.2 → NP_659077.1 protein phosphatase 1 regulatory subunit 1B isoform 1

See identical proteins and their annotated locations for NP_659077.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK141563, BU700812, CX239932, CX240293

Consensus CDS

CCDS25344.1

UniProtKB/Swiss-Prot

A2A564, Q3URF2, Q60829, Q6DV86, Q91XB5

Related

ENSMUSP00000077760.7, ENSMUST00000078694.13

Conserved Domains (1) summary

pfam05395
Location:2 → 107

DARPP-32; Protein phosphatase inhibitor 1/DARPP-32