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    Prl2c3 prolactin family 2, subfamily c, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 18812, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Prl2c3provided by MGI
    Official Full Name
    prolactin family 2, subfamily c, member 3provided by MGI
    Primary source
    MGI:MGI:1341833
    See related
    Ensembl:ENSMUSG00000056457 AllianceGenome:MGI:1341833
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ghd1; Plf2; MRP-2; MRP-3; PLF-2; PLF-3; Prl2c4; Mrpplf3; mrp/plf3
    Summary
    Enables growth factor activity and hormone activity. Acts upstream of or within positive regulation of cell population proliferation. Located in extracellular space. Is expressed in ectoplacental cone; extraembryonic component; and placenta. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward placenta adult (RPKM 2865.0) See more
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    Genomic context

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    Location:
    13; 13 A1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (12805705..12814982, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (12790816..12800093, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nidogen-1-like Neighboring gene STARR-positive B cell enhancer ABC_E7202 Neighboring gene NHP2-like protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr13:12896090-12896390 Neighboring gene STARR-seq mESC enhancer starr_33671 Neighboring gene STARR-positive B cell enhancer mm9_chr13:12913866-12914166 Neighboring gene predicted gene, 53256 Neighboring gene STARR-positive B cell enhancer mm9_chr13:12918988-12919289 Neighboring gene R3H domain containing 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel role for proliferin-2 in the ex vivo expansion of hematopoietic stem cells. Choong ML, et al. FEBS Lett, 2003 Aug 28. PMID 12935903
    2. Characterization of a mouse mitogen-regulated protein/proliferin gene and its promoter: a member of the growth hormone/prolactin gene superfamily. Connor AM, et al. Biochim Biophys Acta, 1989 Sep 21. PMID 2790033
    3. Identification of proliferin mRNA and protein in mouse placenta. Linzer DI, et al. Proc Natl Acad Sci U S A, 1985 Jul. PMID 3859868, Free PMC Article
    4. Proliferin enhances microvilli formation and cell growth of neuroblastoma cells. Wang JW, et al. Neurosci Res, 2006 Sep. PMID 16876275
    5. The mouse prolactin gene family locus. Wiemers DO, et al. Endocrinology, 2003 Jan. PMID 12488360

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hormone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of hematopoietic stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolactin-2C3
    Names
    growth hormone d1
    mitogen-regulated protein 2
    mitogen-regulated protein 3
    prolactin-2C4
    proliferin-2
    proliferin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011118.2 → NP_035248.2  prolactin-2C3 precursor

      See identical proteins and their annotated locations for NP_035248.2

      Status: VALIDATED

      Source sequence(s)
      AK164068, BU755317
      Consensus CDS
      CCDS36595.1
      UniProtKB/Swiss-Prot
      P04768, P18918, Q498A5, Q6PDB6
      UniProtKB/TrEMBL
      A0A0M5HDY5, Q6P215, Q7TND2
      Related
      ENSMUSP00000097393.2, ENSMUST00000099805.3
      Conserved Domains (1) summary
      pfam00103
      Location:33 → 224
      Hormone_1; Somatotropin hormone family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      12805705..12814982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516579.1 → XP_006516642.1  prolactin-2C3 isoform X2

      UniProtKB/TrEMBL
      Q7TND2
      Conserved Domains (1) summary
      cl07831
      Location:24 → 188
      growth_hormone_like; Somatotropin/prolactin hormone family

    2. XM_006516578.4 → XP_006516641.1  prolactin-2C3 isoform X1

      UniProtKB/TrEMBL
      Q6P215, Q7TND2
      Conserved Domains (1) summary
      pfam00103
      Location:22 → 222
      Hormone_1; Somatotropin hormone family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04768.2 GenPept UniProtKB/Swiss-Prot:P04768

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