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    Amd2 S-adenosylmethionine decarboxylase 2 [ Mus musculus (house mouse) ]

    Gene ID: 100041585, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Amd2provided by MGI
    Official Full Name
    S-adenosylmethionine decarboxylase 2provided by MGI
    Primary source
    MGI:MGI:1333111
    See related
    Ensembl:ENSMUSG00000063953 AllianceGenome:MGI:1333111
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Amd1; Amd3; AdoMetDC
    Summary
    Enables adenosylmethionine decarboxylase activity. Predicted to be involved in S-adenosylmethionine metabolic process; spermidine biosynthetic process; and spermine biosynthetic process. Predicted to act upstream of or within polyamine biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Amd2 in Genome Data Viewer
    Location:
    10 B1; 10 19.13 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (35584687..35587887, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (35708691..35711891, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26292 Neighboring gene STARR-seq mESC enhancer starr_26293 Neighboring gene STARR-seq mESC enhancer starr_26294 Neighboring gene STARR-seq mESC enhancer starr_26296 Neighboring gene STARR-seq mESC enhancer starr_26297 Neighboring gene STARR-seq mESC enhancer starr_26298 Neighboring gene STARR-seq mESC enhancer starr_26299 Neighboring gene STARR-seq mESC enhancer starr_26300 Neighboring gene predicted gene, 26341 Neighboring gene STARR-seq mESC enhancer starr_26301 Neighboring gene vacuolar protein sorting 54 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26302 Neighboring gene STARR-seq mESC enhancer starr_26303 Neighboring gene STARR-seq mESC enhancer starr_26304 Neighboring gene STARR-seq mESC enhancer starr_26305 Neighboring gene STARR-seq mESC enhancer starr_26306 Neighboring gene STARR-seq mESC enhancer starr_26308 Neighboring gene STARR-seq mESC enhancer starr_26309 Neighboring gene STARR-seq mESC enhancer starr_26310 Neighboring gene STARR-seq mESC enhancer starr_26311 Neighboring gene STARR-seq mESC enhancer starr_26312 Neighboring gene STARR-seq mESC enhancer starr_26313 Neighboring gene STARR-seq mESC enhancer starr_26314 Neighboring gene STARR-seq mESC enhancer starr_26315 Neighboring gene STARR-seq mESC enhancer starr_26316 Neighboring gene STARR-seq mESC enhancer starr_26317 Neighboring gene STARR-seq mESC enhancer starr_26318 Neighboring gene predicted gene, 40623 Neighboring gene STARR-seq mESC enhancer starr_26319 Neighboring gene STARR-seq mESC enhancer starr_26320 Neighboring gene STARR-seq mESC enhancer starr_26322 Neighboring gene STARR-seq mESC enhancer starr_26323 Neighboring gene STARR-seq mESC enhancer starr_26324 Neighboring gene STARR-seq mESC enhancer starr_26325 Neighboring gene VISTA enhancer mm693 Neighboring gene STARR-seq mESC enhancer starr_26326 Neighboring gene STARR-seq mESC enhancer starr_26327 Neighboring gene STARR-seq mESC enhancer starr_26330 Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 5 Neighboring gene predicted gene, 22554

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and sequencing of an intronless mouse S-adenosylmethionine decarboxylase gene coding for a functional enzyme strongly expressed in the liver. Persson K, et al. J Biol Chem, 1995 Mar 10. PMID 7890685
    2. Mouse chromosome 19. Guénet JL. Mamm Genome, 1991. PMID 1823552
    3. The functional intronless S-adenosylmethionine decarboxylase gene of the mouse (Amd-2) is linked to the ornithine decarboxylase gene (Odc) on chromosome 12 and is present in distantly related species of the genus Mus. Persson K, et al. Mamm Genome, 1999 Aug. PMID 10430664
    4. Structure and activity of mouse S-adenosylmethionine decarboxylase gene promoters and properties of the encoded proteins. Nishimura K, et al. Biochem J, 1998 Jun 15. PMID 9620866, Free PMC Article
    5. Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing. Sah RK, et al. PLoS One, 2019. PMID 31291246, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adenosylmethionine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosylmethionine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenosylmethionine decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables putrescine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables putrescine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within polyamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermidine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    S-adenosylmethionine decarboxylase proenzyme 2
    Names
    AdoMetDC 1
    S-adenosylmethionine decarboxylase proenzyme 1
    SAMDC 1
    SAMDC 2
    adenosylmethionine decarboxylase 2
    adoMetDC 2
    NP_031470.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007444.3 → NP_031470.3  S-adenosylmethionine decarboxylase proenzyme 2

      See identical proteins and their annotated locations for NP_031470.3

      Status: VALIDATED

      Source sequence(s)
      AC147238
      Consensus CDS
      CCDS48536.1
      UniProtKB/Swiss-Prot
      D3Z6H8
      Related
      ENSMUSP00000079703.3, ENSMUST00000080898.4
      Conserved Domains (1) summary
      pfam01536
      Location:4 → 325
      SAM_decarbox; Adenosylmethionine decarboxylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      35584687..35587887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_007145.1: Suppressed sequence

      Description
      NG_007145.1: This RefSeq was permanently suppressed because there is evidence that this gene encodes a functional protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3Z6H8.1 GenPept UniProtKB/Swiss-Prot:D3Z6H8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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