Ankrd33 ankyrin repeat domain 33 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ankrd33provided by MGI
Official Full Name: ankyrin repeat domain 33provided by MGI
Primary source: MGI:MGI:2443398
See related: Ensembl:ENSMUSG00000047034 AllianceGenome:MGI:2443398
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Panky; Panky-a; A930021G21Rik
Summary: Acts upstream of or within negative regulation of transcription by RNA polymerase II; negative regulation of transcription regulatory region DNA binding activity; and skeletal muscle cell differentiation. Located in cytosol and nucleus. Is expressed in pineal gland; retina; retina inner nuclear layer; retina outer nuclear layer; and testis. Orthologous to human ANKRD33 (ankyrin repeat domain 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 56.39 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101013625..101017923)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101115744..101120028)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studies isolated Panky/Ankrd33, a gene encoding an ankyrin repeat-containing protein and that PANKY inhibited the DNA-binding activity of CRX.
Title: Panky, a novel photoreceptor-specific ankyrin repeat protein, is a transcriptional cofactor that suppresses CRX-regulated photoreceptor genes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: photoreceptor ankyrin repeat protein

Names: ankyrin repeat domain-containing protein 33; photorecptor ankyrin repeat protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355656.1 → NP_001342585.1 photoreceptor ankyrin repeat protein isoform 2

Status: VALIDATED

Source sequence(s)

AC104834

Conserved Domains (2) summary

cd00204
Location:1 → 118

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:29 → 62

ANK; ANK repeat [structural motif]
NM_001374225.1 → NP_001361154.1 photoreceptor ankyrin repeat protein isoform 3

Status: VALIDATED

Source sequence(s)

AC104834

UniProtKB/Swiss-Prot

D5G1T0, Q8BXP4, Q8BXP5, Q8R1Z1

Related

ENSMUSP00000155584.2, ENSMUST00000229954.2

Conserved Domains (4) summary

sd00045
Location:53 → 85

ANK; ANK repeat [structural motif]

pfam12796
Location:58 → 153

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:18 → 73

Ank_4; Ankyrin repeats (many copies)

cl39094
Location:127 → 192

Ank_2; Ankyrin repeats (3 copies)
NM_144790.1 → NP_659039.1 photoreceptor ankyrin repeat protein isoform 1

See identical proteins and their annotated locations for NP_659039.1

Status: VALIDATED

Source sequence(s)

BC022726

Consensus CDS

CCDS27845.1

UniProtKB/Swiss-Prot

Q8BXP5

Related

ENSMUSP00000067028.7, ENSMUST00000070875.8

Conserved Domains (3) summary

cd00204
Location:7 → 128

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:10 → 105

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:5 → 37

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

101013625..101017923

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159294.1 → XP_036015187.1 photoreceptor ankyrin repeat protein isoform X1

Conserved Domains (2) summary

sd00045
Location:29 → 62

ANK; ANK repeat [structural motif]

pfam12796
Location:1 → 95

Ank_2; Ankyrin repeats (3 copies)