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    Plcd3 phospholipase C, delta 3 [ Mus musculus (house mouse) ]

    Gene ID: 72469, updated on 12-May-2024

    Summary

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    Official Symbol
    Plcd3provided by MGI
    Official Full Name
    phospholipase C, delta 3provided by MGI
    Primary source
    MGI:MGI:107451
    See related
    Ensembl:ENSMUSG00000020937 AllianceGenome:MGI:107451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1964; 2610205J15Rik
    Summary
    Predicted to enable phosphatidylinositol phospholipase C activity. Acts upstream of or within angiogenesis; labyrinthine layer blood vessel development; and regulation of cell population proliferation. Predicted to be located in cytosol and membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human PLCD3 (phospholipase C delta 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 8.4), stomach adult (RPKM 7.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plcd3 in Genome Data Viewer
    Location:
    11 E1; 11 66.71 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102960062..102992484, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103070296..103101710, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30823 Neighboring gene dephospho-CoA kinase domain containing Neighboring gene microRNA 6931 Neighboring gene STARR-positive B cell enhancer ABC_E8458 Neighboring gene STARR-positive B cell enhancer ABC_E7071 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102889625-102889808 Neighboring gene STARR-seq mESC enhancer starr_30825 Neighboring gene N-myristoyltransferase 1 Neighboring gene predicted gene, 42090 Neighboring gene STARR-seq mESC enhancer starr_30831 Neighboring gene STARR-positive B cell enhancer ABC_E204 Neighboring gene acyl-Coenzyme A binding domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E4004 Neighboring gene STARR-positive B cell enhancer ABC_E738 Neighboring gene hexamethylene bis-acetamide inducible 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and neurite outgrowth. Kouchi Z, et al. J Biol Chem, 2011 Mar 11. PMID 21187285, Free PMC Article
    2. Phospholipase Cδ3 is a novel binding partner of myosin VI and functions as anchoring of myosin VI on plasma membrane. Sakurai K, et al. Adv Enzyme Regul, 2011. PMID 21035487
    3. Physiological functions of phospholipase C delta-type. Fukami K, et al. Adv Enzyme Regul, 2008. PMID 18177742
    4. Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant. Runkel F, et al. PLoS One, 2012. PMID 22723964, Free PMC Article
    5. Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy. Nakamura Y, et al. Cell Death Dis, 2014 May 8. PMID 24810051, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that PLCdelta1 and PLCdelta3 are required for cardiomyocyte survival and normal cardiac function.
      Title: Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy.
    2. Plcd1 and Plcd3 have synergistic effects on the murine hair follicle in specific regions of the body surface.
      Title: Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant.
    3. These results indicate that PLCdelta3 could participate in stability of microvilli structure via regulating and anchoring of Myo6 to plasma membrane.
      Title: Phospholipase Cδ3 is a novel binding partner of myosin VI and functions as anchoring of myosin VI on plasma membrane.
    4. PLCdelta3 negatively regulates RhoA expression, inhibits RhoA/Rho kinase signaling, and thereby promotes neurite extension.
      Title: Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and neurite outgrowth.
    5. double disruption of PLCd1 and PLCd3 results in embryonic lethality because of insufficient vasculariztion of the placenta.
      Title: Physiological functions of phospholipase C delta-type.
    6. PLCdelta1 and PLCdelta3 are essential in trophoblasts for placental development.
      Title: Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within labyrinthine layer blood vessel development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
    Names
    PLC-delta-3
    phosphoinositide phospholipase C-delta-3
    NP_001348635.1
    NP_690026.2
    XP_006534371.1
    XP_006534372.1
    XP_017170277.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361706.1 → NP_001348635.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL731805
      Conserved Domains (4) summary
      cd08630
      Location:272 → 567
      PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
      cd13363
      Location:1 → 117
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:137 → 186
      EF-hand_10; EF hand
      cl27705
      Location:191 → 718
      PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

    2. NM_152813.3 → NP_690026.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform 1

      See identical proteins and their annotated locations for NP_690026.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK011892, AK046669, AL731805, BY011789, BY589869
      Consensus CDS
      CCDS25512.1
      UniProtKB/Swiss-Prot
      A2AHR0, A2AHR1, Q3UME8, Q69Z55, Q8BL19, Q8K2J0
      Related
      ENSMUSP00000099366.2, ENSMUST00000103077.2
      Conserved Domains (7) summary
      cd00275
      Location:656 → 783
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08630
      Location:332 → 627
      PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
      PLN02228
      Location:251 → 778
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:61 → 177
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam00169
      Location:66 → 163
      PH; PH domain
      pfam09279
      Location:251 → 332
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam14788
      Location:197 → 246
      EF-hand_10; EF hand

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102960062..102992484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534308.4 → XP_006534371.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1

      Conserved Domains (4) summary
      PLN02228
      Location:251 → 777
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:61 → 177
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:197 → 246
      EF-hand_10; EF hand
      cl14615
      Location:332 → 626
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    2. XM_006534309.5 → XP_006534372.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2

      Conserved Domains (4) summary
      cd08630
      Location:291 → 586
      PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
      PLN02228
      Location:210 → 737
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:20 → 136
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:156 → 205
      EF-hand_10; EF hand

    3. XM_017314788.3 → XP_017170277.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X3

      UniProtKB/TrEMBL
      F7AAE0
      Related
      ENSMUSP00000117455.2, ENSMUST00000128650.8
      Conserved Domains (2) summary
      cd00275
      Location:343 → 470
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cl14615
      Location:20 → 314
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2J0.2 GenPept UniProtKB/Swiss-Prot:Q8K2J0

    Gene LinkOut

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