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    Arhgap28 Rho GTPase activating protein 28 [ Mus musculus (house mouse) ]

    Gene ID: 268970, updated on 7-May-2024

    Summary

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    Official Symbol
    Arhgap28provided by MGI
    Official Full Name
    Rho GTPase activating protein 28provided by MGI
    Primary source
    MGI:MGI:2147003
    See related
    Ensembl:ENSMUSG00000024043 AllianceGenome:MGI:2147003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E130310N06
    Summary
    Predicted to enable GTPase activator activity. Acts upstream of or within negative regulation of GTP binding activity and negative regulation of stress fiber assembly. Predicted to be active in cytoplasm. Orthologous to human ARHGAP28 (Rho GTPase activating protein 28). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in limb E14.5 (RPKM 7.1), ovary adult (RPKM 4.6) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E1.1- E1.2; 17 38.9 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (68149701..68311185, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (67842706..68004197, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52321 Neighboring gene leucine rich repeat containing 30 Neighboring gene laminin, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_43107 Neighboring gene STARR-seq mESC enhancer starr_43108 Neighboring gene STARR-seq mESC enhancer starr_43110 Neighboring gene STARR-seq mESC enhancer starr_43111 Neighboring gene predicted gene, 36252 Neighboring gene predicted gene, 36312 Neighboring gene L3MBTL4 histone methyl-lysine binding protein Neighboring gene peroxiredoxin 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers. Yeung CY, et al. PLoS One, 2014. PMID 25211221, Free PMC Article
    2. Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. Santos R, et al. PLoS Biol, 2016 Sep. PMID 27606604, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    4. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. Müller PM, et al. Nat Cell Biol, 2020 Apr. PMID 32203420
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 28
    Names
    rho-type GTPase-activating protein 28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347410.1 → NP_001334339.1  rho GTPase-activating protein 28 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154823, AC164159, CO043770
      Consensus CDS
      CCDS84329.1
      UniProtKB/TrEMBL
      A0A2X0SYT7
      Related
      ENSMUSP00000130960.2, ENSMUST00000163865.8

    2. NM_001426794.1 → NP_001413723.1  rho GTPase-activating protein 28 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154823, AC164159
      UniProtKB/TrEMBL
      E9Q642

    3. NM_001426795.1 → NP_001413724.1  rho GTPase-activating protein 28 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154823, AC164159
      UniProtKB/TrEMBL
      E9Q642

    4. NM_172964.4 → NP_766552.3  rho GTPase-activating protein 28 isoform 1

      See identical proteins and their annotated locations for NP_766552.3

      Status: VALIDATED

      Source sequence(s)
      AK087523, AK133720, AK141901, BB372888
      Consensus CDS
      CCDS28950.1
      UniProtKB/Swiss-Prot
      Q3TSH7, Q3UR11, Q3UZQ7, Q69ZM1, Q6NY11, Q8BN58
      UniProtKB/TrEMBL
      A0A2X0SYT7
      Related
      ENSMUSP00000024840.6, ENSMUST00000024840.12
      Conserved Domains (1) summary
      cd04391
      Location:381 → 592
      RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      68149701..68311185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160630.1 → XP_036016523.1  rho GTPase-activating protein 28 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SYT7
      Conserved Domains (1) summary
      cd04391
      Location:408 → 619
      RhoGAP_ARHGAP18; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...

    2. XM_006524343.5 → XP_006524406.1  rho GTPase-activating protein 28 isoform X2

      See identical proteins and their annotated locations for XP_006524406.1

      UniProtKB/TrEMBL
      A0A2X0SYT7, E9Q642
      Conserved Domains (1) summary
      cd04391
      Location:331 → 542
      RhoGAP_ARHGAP18; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BN58.1 GenPept UniProtKB/Swiss-Prot:Q8BN58

    Gene LinkOut

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