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    Dmtf1 cyclin D binding myb like transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 23857, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dmtf1provided by MGI
    Official Full Name
    cyclin D binding myb like transcription factor 1provided by MGI
    Primary source
    MGI:MGI:1344415
    See related
    Ensembl:ENSMUSG00000042508 AllianceGenome:MGI:1344415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dimp; Dmp1
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and retina. Orthologous to human DMTF1 (cyclin D binding myb like transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 13.2), CNS E18 (RPKM 12.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 A1; 5 3.69 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (9168868..9211782, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (9118868..9161806, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12400 Neighboring gene coiled-coil domain-containing protein 72 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr5:8997064-8997365 Neighboring gene carnitine O-octanoyltransferase Neighboring gene STARR-seq mESC enhancer starr_12401 Neighboring gene STARR-seq mESC enhancer starr_12402 Neighboring gene STARR-seq mESC enhancer starr_12403 Neighboring gene predicted gene, 40264 Neighboring gene STARR-seq mESC enhancer starr_12404 Neighboring gene STARR-seq mESC enhancer starr_12405 Neighboring gene STARR-seq mESC enhancer starr_12406 Neighboring gene transmembrane protein 243, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E10301 Neighboring gene predicted gene, 46901 Neighboring gene predicted gene, 24666 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of murine hematopoietic stem cell quiescence by Dmtf1. Kobayashi M, et al. Blood, 2011 Dec 15. PMID 22039255, Free PMC Article
    2. Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis. Inoue K, et al. Genes Dev, 2000 Jul 15. PMID 10898794, Free PMC Article
    3. Repression of Dmp1 and Arf transcription by anthracyclins: critical roles of the NF-kappaB subunit p65. Taneja P, et al. Oncogene, 2007 Nov 22. PMID 17546045, Free PMC Article
    4. Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas. Inoue K, et al. Genes Dev, 2001 Nov 15. PMID 11711428, Free PMC Article
    5. Regulation of the CD13/aminopeptidase N gene by DMP1, a transcription factor antagonized by D-type cyclins. Inoue K, et al. J Biol Chem, 1998 Oct 30. PMID 9786929

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dmp1 (Dmp1alpha) physically interacts with p53, stabilizes p53's binding to its target genes, and increases the transcriptional activity of p53.
      Title: Stabilization of the p53-DNA Complex by the Nuclear Protein Dmp1α.
    2. This study reveals a pivotal role of combined Dmp1 loss and cyclin D1 overexpression in breast cancer.
      Title: Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer.
    3. new mechanism of p53 activation mediated by direct physical interaction between Dmp1 and p53.
      Title: Dmp1 physically interacts with p53 and positively regulates p53's stability, nuclear localization, and function.
    4. Results implicate Dmtf1 in the regulation of HSC function through novel cell cycle-regulatory mechanisms.
      Title: Regulation of murine hematopoietic stem cell quiescence by Dmtf1.
    5. Data show that Dmp1 directly bound to the genomic loci of Areg, Tsp-1, JunB and Egr1.
      Title: The Arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1.
    6. Approximately 40% of K-ras(LA) lung tumors from Dmp1(+/+) mice lost one allele of the Dmp1 gene, suggesting the primary involvement of Dmp1 in K-ras-induced tumorigenesis.
      Title: Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer.
    7. The Dmp1-Arf pathway is repressed by p65 in response to genotoxic stress.
      Title: Repression of Dmp1 and Arf transcription by anthracyclins: critical roles of the NF-kappaB subunit p65.
    8. a novel Jun-Dmp1 pathway directly links oncogenic Ras-Raf signaling and p19(Arf), independent of the classical cyclin D1/Cdk4-Rb-E2F pathway
      Title: Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-D-binding Myb-like transcription factor 1
    Names
    D-interacting myb-like protein
    cyclin D binding myb-like transcription factor 1D-interacting myb-like protein
    cyclin-D-interacting Myb-like protein 1
    mDmp1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110327.2 → NP_001103797.1  cyclin-D-binding Myb-like transcription factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001103797.1

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
      Consensus CDS
      CCDS51412.1
      UniProtKB/TrEMBL
      V9GXX1
      Related
      ENSMUSP00000092627.5, ENSMUST00000095017.11
      Conserved Domains (4) summary
      smart00717
      Location:274 → 330
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:338 → 388
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    2. NM_001425525.1 → NP_001412454.1  cyclin-D-binding Myb-like transcription factor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121

    3. NM_001425526.1 → NP_001412455.1  cyclin-D-binding Myb-like transcription factor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121

    4. NM_001425527.1 → NP_001412456.1  cyclin-D-binding Myb-like transcription factor 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121

    5. NM_001425528.1 → NP_001412457.1  cyclin-D-binding Myb-like transcription factor 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121

    6. NM_011806.4 → NP_035936.3  cyclin-D-binding Myb-like transcription factor 1 isoform 1

      See identical proteins and their annotated locations for NP_035936.3

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
      Consensus CDS
      CCDS19088.1
      UniProtKB/Swiss-Prot
      P70413, Q3TUR9, Q80VR8, Q8BQX6, Q8CA56, Q8CCZ0, Q8CE22
      UniProtKB/TrEMBL
      V9GXX1
      Related
      ENSMUSP00000071815.6, ENSMUST00000071921.13
      Conserved Domains (3) summary
      COG5147
      Location:122 → 378
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    RNA

    1. NR_152858.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121

    2. NR_152859.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
      Related
      ENSMUST00000184159.8

    3. NR_152860.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121

    4. NR_152861.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
      Related
      ENSMUST00000183448.8

    5. NR_189314.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121

    6. NR_189315.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121

    7. NR_189316.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121

    8. NR_189317.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121

    9. NR_189318.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121

    10. NR_189319.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      9168868..9211782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165110.1 → XP_036021003.1  cyclin-D-binding Myb-like transcription factor 1 isoform X7

      Conserved Domains (2) summary
      smart00717
      Location:70 → 123
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:8 → 63
      Myb_DNA-binding; Myb-like DNA-binding domain

    2. XM_036165108.1 → XP_036021001.1  cyclin-D-binding Myb-like transcription factor 1 isoform X6

      Conserved Domains (3) summary
      COG5147
      Location:81 → 337
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
      pfam13921
      Location:187 → 243
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      pfam00249
      Location:233 → 288
      Myb_DNA-binding; Myb-like DNA-binding domain

    3. XM_036165109.1 → XP_036021002.1  cyclin-D-binding Myb-like transcription factor 1 isoform X7

      Conserved Domains (2) summary
      smart00717
      Location:70 → 123
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:8 → 63
      Myb_DNA-binding; Myb-like DNA-binding domain

    4. XM_011240669.2 → XP_011238971.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

      UniProtKB/TrEMBL
      V9GXX1
      Conserved Domains (3) summary
      COG5147
      Location:122 → 378
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    5. XM_036165107.1 → XP_036021000.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

      UniProtKB/TrEMBL
      V9GXX1
      Conserved Domains (3) summary
      COG5147
      Location:81 → 337
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
      pfam13921
      Location:187 → 243
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      pfam00249
      Location:233 → 288
      Myb_DNA-binding; Myb-like DNA-binding domain

    6. XM_011240668.3 → XP_011238970.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      See identical proteins and their annotated locations for XP_011238970.1

      UniProtKB/Swiss-Prot
      P70413, Q3TUR9, Q80VR8, Q8BQX6, Q8CA56, Q8CCZ0, Q8CE22
      UniProtKB/TrEMBL
      V9GXX1
      Conserved Domains (3) summary
      COG5147
      Location:122 → 378
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    RNA

    1. XR_004942513.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CE22.2 GenPept UniProtKB/Swiss-Prot:Q8CE22

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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