Cndp2 CNDP dipeptidase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cndp2provided by MGI
Official Full Name: CNDP dipeptidase 2provided by MGI
Primary source: MGI:MGI:1913304
See related: Ensembl:ENSMUSG00000024644 AllianceGenome:MGI:1913304
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cn2; Pep1; Dip-2; Pep-1; 0610010E05Rik
Summary: Enables dipeptidase activity. Acts upstream of or within proteolysis. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including 1st branchial arch; ear; limb; nervous system; and urinary system. Orthologous to human CNDP2 (carnosine dipeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in large intestine adult (RPKM 201.3), placenta adult (RPKM 117.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E4; 18 57.53 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (84685590..84703827, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (84667465..84685702, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models
Title: PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models.
These results provide evidence showing that intradimer interaction of H228 with the reaction center of the dimer counterpart is essential to the enzymatic activity of Cn2.
Title: Evidence for an essential role of intradimer interaction in catalytic function of carnosine dipeptidase II using electrospray-ionization mass spectrometry.
These findings suggest that the transduced PEP-1-PRX2 has neuroprotective functions against oxidative stress-induced cell death in vitro and in vivo
Title: Neuroprotective effect of PEP-1-peroxiredoxin2 on CA1 regions in the hippocampus against ischemic insult.
Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2.
Title: Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alanylglutamate dipeptidase activity	IEA Inferred from Electronic Annotation more info
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables dipeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables dipeptidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallodipeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytosolic non-specific dipeptidase

Names: CNDP dipeptidase 2 (metallopeptidase M20 family); cytosolic nonspecific dipeptidase; glutamate carboxypeptidase-like protein 1; peptidase 1; peptidase A; threonyl dipeptidase

NP_001276460.1

EC 3.4.13.18

NP_075638.2

EC 3.4.13.18

XP_030106430.1

EC 3.4.13.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289531.1 → NP_001276460.1 cytosolic non-specific dipeptidase

See identical proteins and their annotated locations for NP_001276460.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein

Source sequence(s)

AK003779, AK152442, CJ306472, CN721222

Consensus CDS

CCDS29383.1

UniProtKB/Swiss-Prot

Q3TA80, Q3TI32, Q3U7B9, Q99PV1, Q9D1A2

UniProtKB/TrEMBL

Q6KAT3

Related

ENSMUSP00000128696.2, ENSMUST00000168419.3

Conserved Domains (1) summary

cd05676
Location:7 → 473

M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
NM_023149.3 → NP_075638.2 cytosolic non-specific dipeptidase

See identical proteins and their annotated locations for NP_075638.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK003779, CJ078789, CJ306472

Consensus CDS

CCDS29383.1

UniProtKB/Swiss-Prot

Q3TA80, Q3TI32, Q3U7B9, Q99PV1, Q9D1A2

UniProtKB/TrEMBL

Q6KAT3

Related

ENSMUSP00000025546.10, ENSMUST00000025546.17

Conserved Domains (1) summary

cd05676
Location:7 → 473

M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

84685590..84703827 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250570.2 → XP_030106430.1 cytosolic non-specific dipeptidase isoform X1

UniProtKB/Swiss-Prot

Q3TA80, Q3TI32, Q3U7B9, Q99PV1, Q9D1A2

UniProtKB/TrEMBL

Q6KAT3

Conserved Domains (1) summary

cd05676
Location:7 → 473

M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase