PRC1 protein regulator of cytokinesis 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRC1provided by HGNC
Official Full Name: protein regulator of cytokinesis 1provided by HGNC
Primary source: HGNC:HGNC:9341
See related: Ensembl:ENSG00000198901 MIM:603484; AllianceGenome:HGNC:9341
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ASE1; MAP65
Summary: This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Expression: Broad expression in bone marrow (RPKM 31.0), testis (RPKM 24.4) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q26.1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (90966040..90994535, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (88725621..88754118, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (91509270..91537765, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein regulator of cytokinesis 1: a potential oncogenic driver.
Title: Protein regulator of cytokinesis 1: a potential oncogenic driver.
Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis.
Title: Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis.
Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India.
Title: Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India.
CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis.
Title: CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis.
Expression of the cytokinesis regulator PRC1 results in p53-pathway activation in A549 cells but does not directly regulate gene expression in the nucleus.
Title: Expression of the cytokinesis regulator PRC1 results in p53-pathway activation in A549 cells but does not directly regulate gene expression in the nucleus.
PRC1 plays an important role in lung adenocarcinoma and is potentially targeted by fostamatinib.
Title: PRC1 plays an important role in lung adenocarcinoma and is potentially targeted by fostamatinib.
Protein Regulator of Cytokinesis 1 (PRC1) Upregulation Promotes Immune Suppression in Liver Hepatocellular Carcinoma.
Title: Protein Regulator of Cytokinesis 1 (PRC1) Upregulation Promotes Immune Suppression in Liver Hepatocellular Carcinoma.
Two modes of PRC1-mediated mechanical resistance to kinesin-driven microtubule network disruption.
Title: Two modes of PRC1-mediated mechanical resistance to kinesin-driven microtubule network disruption.
Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces.
Title: Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces.
TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis.
Title: TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis.

Submit: New GeneRIF Correction See all GeneRIFs (72)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. EBI GWAS Catalog EBI GWAS CatalogPubMed
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle elongation	TAS Traceable Author Statement more info	PubMed
involved_in mitotic spindle midzone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokinesis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in contractile ring	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intercellular bridge	IDA Inferred from Direct Assay more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle microtubule	TAS Traceable Author Statement more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein regulator of cytokinesis 1

Names: anaphase spindle elongation 1 homolog; protein regulating cytokinesis 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_050647.2 RefSeqGene

Range

5000..33495

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001267580.2 → NP_001254509.2 protein regulator of cytokinesis 1 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and uses and alternate splice site and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC068831

Consensus CDS

CCDS45353.2

Related

ENSP00000409549.2, ENST00000442656.6

Conserved Domains (1) summary

pfam03999
Location:22 → 508

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
NM_003981.4 → NP_003972.2 protein regulator of cytokinesis 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC068831

Consensus CDS

CCDS32334.1

UniProtKB/Swiss-Prot

A6NC44, B4DLR1, H9KV59, O43663, Q9BSB6

Related

ENSP00000377793.3, ENST00000394249.8

Conserved Domains (1) summary

pfam03999
Location:37 → 615

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
NM_199413.3 → NP_955445.2 protein regulator of cytokinesis 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.

Source sequence(s)

AC068831

Consensus CDS

CCDS45352.1

Related

ENSP00000354679.5, ENST00000361188.9

Conserved Domains (1) summary

COG1196
Location:96 → 414

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

90966040..90994535 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017022714.3 → XP_016878203.1 protein regulator of cytokinesis 1 isoform X7
XM_047433314.1 → XP_047289270.1 protein regulator of cytokinesis 1 isoform X29
XM_047433310.1 → XP_047289266.1 protein regulator of cytokinesis 1 isoform X26
XM_011522192.3 → XP_011520494.1 protein regulator of cytokinesis 1 isoform X20

Conserved Domains (4) summary

pfam03999
Location:37 → 494

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

pfam08418
Location:306 → 444

Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

pfam13094
Location:35 → 180

CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit

cl00711
Location:141 → 304

Glyco_hydro_77; 4-alpha-glucanotransferase
XM_047433313.1 → XP_047289269.1 protein regulator of cytokinesis 1 isoform X28
XM_047433311.1 → XP_047289267.1 protein regulator of cytokinesis 1 isoform X27
XM_047433305.1 → XP_047289261.1 protein regulator of cytokinesis 1 isoform X21
XM_047433306.1 → XP_047289262.1 protein regulator of cytokinesis 1 isoform X22
XM_047433300.1 → XP_047289256.1 protein regulator of cytokinesis 1 isoform X16
XM_047433301.1 → XP_047289257.1 protein regulator of cytokinesis 1 isoform X17
XM_047433309.1 → XP_047289265.1 protein regulator of cytokinesis 1 isoform X25
XM_047433307.1 → XP_047289263.1 protein regulator of cytokinesis 1 isoform X23
XM_047433298.1 → XP_047289254.1 protein regulator of cytokinesis 1 isoform X13
XM_017022716.3 → XP_016878205.1 protein regulator of cytokinesis 1 isoform X14
XM_011522190.4 → XP_011520492.1 protein regulator of cytokinesis 1 isoform X9

Conserved Domains (4) summary

pfam03999
Location:37 → 544

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

pfam08418
Location:356 → 494

Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

pfam13094
Location:35 → 194

CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit

cl00711
Location:203 → 354

Glyco_hydro_77; 4-alpha-glucanotransferase
XM_047433297.1 → XP_047289253.1 protein regulator of cytokinesis 1 isoform X11
XM_047433304.1 → XP_047289260.1 protein regulator of cytokinesis 1 isoform X19
XM_047433299.1 → XP_047289255.1 protein regulator of cytokinesis 1 isoform X15
XM_047433295.1 → XP_047289251.1 protein regulator of cytokinesis 1 isoform X5
XM_017022713.3 → XP_016878202.1 protein regulator of cytokinesis 1 isoform X6
XM_011522189.3 → XP_011520491.1 protein regulator of cytokinesis 1 isoform X3

Conserved Domains (2) summary

pfam03999
Location:37 → 564

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

cl00711
Location:260 → 411

Glyco_hydro_77; 4-alpha-glucanotransferase
XM_017022712.3 → XP_016878201.1 protein regulator of cytokinesis 1 isoform X4
XM_006720760.3 → XP_006720823.1 protein regulator of cytokinesis 1 isoform X12

Conserved Domains (3) summary

pfam03999
Location:37 → 562

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

pfam08418
Location:413 → 562

Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

cl00711
Location:260 → 411

Glyco_hydro_77; 4-alpha-glucanotransferase
XM_005254987.4 → XP_005255044.1 protein regulator of cytokinesis 1 isoform X8

Conserved Domains (3) summary

pfam03999
Location:37 → 560

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

pfam08418
Location:413 → 551

Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

cl00711
Location:260 → 411

Glyco_hydro_77; 4-alpha-glucanotransferase
XM_006720759.3 → XP_006720822.1 protein regulator of cytokinesis 1 isoform X10

See identical proteins and their annotated locations for XP_006720822.1

Conserved Domains (3) summary

pfam03999
Location:37 → 549

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

pfam08418
Location:413 → 560

Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

cl00711
Location:260 → 411

Glyco_hydro_77; 4-alpha-glucanotransferase
XM_011522188.4 → XP_011520490.1 protein regulator of cytokinesis 1 isoform X2

Conserved Domains (3) summary

pfam03999
Location:37 → 583

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

pfam08418
Location:413 → 551

Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

cl00711
Location:260 → 411

Glyco_hydro_77; 4-alpha-glucanotransferase
XM_011522187.3 → XP_011520489.1 protein regulator of cytokinesis 1 isoform X1

Conserved Domains (3) summary

pfam03999
Location:37 → 601

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

pfam08418
Location:413 → 551

Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

cl00711
Location:260 → 411

Glyco_hydro_77; 4-alpha-glucanotransferase
XM_047433308.1 → XP_047289264.1 protein regulator of cytokinesis 1 isoform X24
XM_047433303.1 → XP_047289259.1 protein regulator of cytokinesis 1 isoform X18
XM_011522191.4 → XP_011520493.1 protein regulator of cytokinesis 1 isoform X10

See identical proteins and their annotated locations for XP_011520493.1

Conserved Domains (3) summary

pfam03999
Location:37 → 549

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

pfam08418
Location:413 → 560

Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

cl00711
Location:260 → 411

Glyco_hydro_77; 4-alpha-glucanotransferase

Alternate T2T-CHM13v2.0

Genomic

NC_060939.1 Alternate T2T-CHM13v2.0

Range

88725621..88754118 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054379147.1 → XP_054235122.1 protein regulator of cytokinesis 1 isoform X7
XM_054379170.1 → XP_054235145.1 protein regulator of cytokinesis 1 isoform X29
XM_054379167.1 → XP_054235142.1 protein regulator of cytokinesis 1 isoform X26
XM_054379161.1 → XP_054235136.1 protein regulator of cytokinesis 1 isoform X20
XM_054379169.1 → XP_054235144.1 protein regulator of cytokinesis 1 isoform X28
XM_054379168.1 → XP_054235143.1 protein regulator of cytokinesis 1 isoform X27
XM_054379162.1 → XP_054235137.1 protein regulator of cytokinesis 1 isoform X21
XM_054379163.1 → XP_054235138.1 protein regulator of cytokinesis 1 isoform X22
XM_054379157.1 → XP_054235132.1 protein regulator of cytokinesis 1 isoform X16
XM_054379158.1 → XP_054235133.1 protein regulator of cytokinesis 1 isoform X17
XM_054379166.1 → XP_054235141.1 protein regulator of cytokinesis 1 isoform X25
XM_054379164.1 → XP_054235139.1 protein regulator of cytokinesis 1 isoform X23
XM_054379154.1 → XP_054235129.1 protein regulator of cytokinesis 1 isoform X13
XM_054379155.1 → XP_054235130.1 protein regulator of cytokinesis 1 isoform X14
XM_054379149.1 → XP_054235124.1 protein regulator of cytokinesis 1 isoform X9
XM_054379151.1 → XP_054235126.1 protein regulator of cytokinesis 1 isoform X11
XM_054379160.1 → XP_054235135.1 protein regulator of cytokinesis 1 isoform X19
XM_054379156.1 → XP_054235131.1 protein regulator of cytokinesis 1 isoform X15
XM_054379145.1 → XP_054235120.1 protein regulator of cytokinesis 1 isoform X5
XM_054379146.1 → XP_054235121.1 protein regulator of cytokinesis 1 isoform X6
XM_054379143.1 → XP_054235118.1 protein regulator of cytokinesis 1 isoform X3
XM_054379144.1 → XP_054235119.1 protein regulator of cytokinesis 1 isoform X4
XM_054379153.1 → XP_054235128.1 protein regulator of cytokinesis 1 isoform X12
XM_054379148.1 → XP_054235123.1 protein regulator of cytokinesis 1 isoform X8
XM_054379152.1 → XP_054235127.1 protein regulator of cytokinesis 1 isoform X10
XM_054379142.1 → XP_054235117.1 protein regulator of cytokinesis 1 isoform X2
XM_054379141.1 → XP_054235116.1 protein regulator of cytokinesis 1 isoform X1
XM_054379165.1 → XP_054235140.1 protein regulator of cytokinesis 1 isoform X24
XM_054379159.1 → XP_054235134.1 protein regulator of cytokinesis 1 isoform X18
XM_054379150.1 → XP_054235125.1 protein regulator of cytokinesis 1 isoform X10

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_199414.1: Suppressed sequence

Description

NM_199414.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.