CTNNBIP1 catenin beta interacting protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CTNNBIP1provided by HGNC
Official Full Name: catenin beta interacting protein 1provided by HGNC
Primary source: HGNC:HGNC:16913
See related: Ensembl:ENSG00000178585 MIM:607758; AllianceGenome:HGNC:16913
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ICAT
Summary: The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in skin (RPKM 77.0), esophagus (RPKM 25.4) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (9848276..9910269, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (9391187..9453193, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (9908334..9970327, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LINC00355 Mediates CTNNBIP1 Promoter Methylation and Promotes Endoplasmic Reticulum Stress-Induced Podocyte Injury in Diabetic Nephropathy.
Title: LINC00355 Mediates CTNNBIP1 Promoter Methylation and Promotes Endoplasmic Reticulum Stress-Induced Podocyte Injury in Diabetic Nephropathy.
ICAT promotes colorectal cancer metastasis via binding to JUP and activating the NF-kappaB signaling pathway.
Title: ICAT promotes colorectal cancer metastasis via binding to JUP and activating the NF-κB signaling pathway.
Expression level and prognostic potential of beta-catenin-interacting protein in acute myeloid leukemia.
Title: Expression level and prognostic potential of beta-catenin-interacting protein in acute myeloid leukemia.
Overexpression of ICAT Inhibits the Progression of Colorectal Cancer by Binding with beta-Catenin in the Cytoplasm.
Title: Overexpression of ICAT Inhibits the Progression of Colorectal Cancer by Binding with β-Catenin in the Cytoplasm.
MiR-486-3p promotes osteogenic differentiation of BMSC by targeting CTNNBIP1 and activating the Wnt/beta-catenin pathway.
Title: MiR-486-3p promotes osteogenic differentiation of BMSC by targeting CTNNBIP1 and activating the Wnt/β-catenin pathway.
Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/beta-catenin signaling pathway.
Title: Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathway.
beta-catenin activates TGF-beta-induced epithelial-mesenchymal transition in adenomyosis.
Title: β-catenin activates TGF-β-induced epithelial-mesenchymal transition in adenomyosis.
CTNNBIP1 modulates keratinocyte proliferation through promoting the transcription of beta-catenin/TCF complex downstream genes.
Title: CTNNBIP1 modulates keratinocyte proliferation through promoting the transcription of β-catenin/TCF complex downstream genes.
miR2963p promotes the proliferation of glioblastoma cells by targeting ICAT.
Title: miR‑296‑3p promotes the proliferation of glioblastoma cells by targeting ICAT.
These findings suggest that CTNNBIP1 is a suppressor of cancer migration, thus making it a potential prognostic predictor for lung cancer.
Title: The Alteration of CTNNBIP1 in Lung Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (94)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-74198 (e-PCR)
- UniSTS:69422

SHGC-74197 (e-PCR)
- UniSTS:32818

AL033871 (e-PCR)
- UniSTS:93747

SHGC-74192 (e-PCR)
- UniSTS:74299

HSC13F032 (e-PCR)
- UniSTS:21319

SHGC-30730 (e-PCR)
- UniSTS:63320

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables armadillo repeat domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
involved_in branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription initiation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of monocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vascular permeability involved in acute inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin destruction complex	IBA Inferred from Biological aspect of Ancestor more info
part_of beta-catenin destruction complex	IDA Inferred from Direct Assay more info	PubMed
part_of beta-catenin-ICAT complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: beta-catenin-interacting protein 1

Names: beta-catenin-interacting protein ICAT; inhibitor of beta-catenin and Tcf-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029165.1 RefSeqGene

Range

4990..66983

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001012329.2 → NP_001012329.1 beta-catenin-interacting protein 1

See identical proteins and their annotated locations for NP_001012329.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL357140, CB995652

Consensus CDS

CCDS106.1

UniProtKB/Swiss-Prot

Q5T4V2, Q9NSA3

Related

ENSP00000383696.3, ENST00000400904.7

Conserved Domains (1) summary

pfam06384
Location:1 → 79

ICAT; Beta-catenin-interacting protein ICAT
NM_020248.3 → NP_064633.1 beta-catenin-interacting protein 1

See identical proteins and their annotated locations for NP_064633.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL357140, BI226022, CB995652

Consensus CDS

CCDS106.1

UniProtKB/Swiss-Prot

Q5T4V2, Q9NSA3

Related

ENSP00000366474.1, ENST00000377263.6

Conserved Domains (1) summary

pfam06384
Location:1 → 79

ICAT; Beta-catenin-interacting protein ICAT

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

9848276..9910269 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047425762.1 → XP_047281718.1 beta-catenin-interacting protein 1 isoform X1
XM_047425765.1 → XP_047281721.1 beta-catenin-interacting protein 1 isoform X1
XM_047425763.1 → XP_047281719.1 beta-catenin-interacting protein 1 isoform X1
XM_047425770.1 → XP_047281726.1 beta-catenin-interacting protein 1 isoform X3

UniProtKB/Swiss-Prot

Q5T4V2, Q9NSA3
XM_047425766.1 → XP_047281722.1 beta-catenin-interacting protein 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

9391187..9453193 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054337777.1 → XP_054193752.1 beta-catenin-interacting protein 1 isoform X1
XM_054337779.1 → XP_054193754.1 beta-catenin-interacting protein 1 isoform X1
XM_054337778.1 → XP_054193753.1 beta-catenin-interacting protein 1 isoform X1
XM_054337780.1 → XP_054193755.1 beta-catenin-interacting protein 1 isoform X3

UniProtKB/Swiss-Prot

Q5T4V2, Q9NSA3
XM_054337782.1 → XP_054193757.1 beta-catenin-interacting protein 1 isoform X3

UniProtKB/Swiss-Prot

Q5T4V2, Q9NSA3
XM_054337781.1 → XP_054193756.1 beta-catenin-interacting protein 1 isoform X3

UniProtKB/Swiss-Prot

Q5T4V2, Q9NSA3