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    Vps28 vacuolar protein sorting 28 [ Mus musculus (house mouse) ]

    Gene ID: 66914, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Vps28provided by MGI
    Official Full Name
    vacuolar protein sorting 28provided by MGI
    Primary source
    MGI:MGI:1914164
    See related
    Ensembl:ENSMUSG00000115987 AllianceGenome:MGI:1914164
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CIIA; 1110014J03Rik; D730005C08Rik
    Summary
    This gene encodes a protein which is thought to be a subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 132.5), duodenum adult (RPKM 102.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D3; 15 36.17 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76506286..76510284, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76622086..76626084, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene aarF domain containing kinase 5 Neighboring gene cleavage and polyadenylation specific factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E1480 Neighboring gene STARR-seq mESC enhancer starr_39057 Neighboring gene solute carrier family 39 (zinc transporter), member 4 Neighboring gene tonsoku-like, DNA repair protein Neighboring gene STARR-positive B cell enhancer ABC_E1481 Neighboring gene zinc finger TRAF type containing 1 Neighboring gene predicted gene, 57852 Neighboring gene STARR-positive B cell enhancer ABC_E760

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CIIA functions as a molecular switch for the Rac1-specific GEF activity of SOS1. Hwang HS, et al. J Cell Biol, 2011 Oct 31. PMID 22042618, Free PMC Article
    2. Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities. Cho SG, et al. J Cell Biol, 2003 Oct 13. PMID 14557248, Free PMC Article
    3. CIIA negatively regulates neuronal cell death induced by oxygen-glucose deprivation and reoxygenation. Hwang SG, et al. Mol Cell Biochem, 2014 Dec. PMID 25098452
    4. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CIIA attenuates neurotoxicity caused by OGD/R through inhibiting ASK1-dependent signaling events.
      Title: CIIA negatively regulates neuronal cell death induced by oxygen-glucose deprivation and reoxygenation.
    2. CIIA functions as a molecular switch for the GEF activity of SOS1, directing this activity toward Rac1.
      Title: CIIA functions as a molecular switch for the Rac1-specific GEF activity of SOS1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome transport via multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ubiquitin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting-associated protein 28 homolog
    Names
    ESCRT-I complex subunit VPS28
    caspase-activated DNase inhibitor that interacts with ASK1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305668.1 → NP_001292597.1  vacuolar protein sorting-associated protein 28 homolog isoform 2

      See identical proteins and their annotated locations for NP_001292597.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site at an internal exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC157566, AK003572, AK003699, BY083019
      Consensus CDS
      CCDS88789.1
      UniProtKB/TrEMBL
      A0A2R8VKS6, Q8BMZ7
      Related
      ENSMUSP00000155847.2, ENSMUST00000229019.2
      Conserved Domains (1) summary
      pfam03997
      Location:1 → 181
      VPS28; VPS28 protein

    2. NM_025842.4 → NP_080118.1  vacuolar protein sorting-associated protein 28 homolog isoform 1

      See identical proteins and their annotated locations for NP_080118.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC157566, AK003699, AK013852, BY083019
      Consensus CDS
      CCDS27579.1
      UniProtKB/Swiss-Prot
      Q9D1C8
      UniProtKB/TrEMBL
      Q8BMZ7
      Related
      ENSMUSP00000077856.4, ENSMUST00000078803.5
      Conserved Domains (1) summary
      pfam03997
      Location:39 → 219
      VPS28; VPS28 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76506286..76510284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1C8.1 GenPept UniProtKB/Swiss-Prot:Q9D1C8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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