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    Taok3 TAO kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 330177, updated on 12-May-2024

    Summary

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    Official Symbol
    Taok3provided by MGI
    Official Full Name
    TAO kinase 3provided by MGI
    Primary source
    MGI:MGI:3041177
    See related
    Ensembl:ENSMUSG00000061288 AllianceGenome:MGI:3041177
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A130052D22; 2900006A08Rik; A430105I05Rik
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; protein autophosphorylation; and regulation of MAPK cascade. Predicted to act upstream of or within DNA repair and phosphorylation. Predicted to be active in cytoplasm. Is expressed in renal vasculature. Orthologous to human TAOK3 (TAO kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 7.8), liver E14.5 (RPKM 6.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 56.88 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (117258180..117413283)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117120111..117275101)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42011 Neighboring gene suppressor of defective silencing 3 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E3606 Neighboring gene STARR-positive B cell enhancer ABC_E2172 Neighboring gene STARR-seq mESC enhancer starr_14168 Neighboring gene STARR-positive B cell enhancer ABC_E6369 Neighboring gene STARR-positive B cell enhancer ABC_E3607 Neighboring gene STARR-positive B cell enhancer ABC_E3608 Neighboring gene STARR-positive B cell enhancer ABC_E3609 Neighboring gene STARR-seq mESC enhancer starr_14169 Neighboring gene STARR-positive B cell enhancer ABC_E8074 Neighboring gene phosphatidylethanolamine binding protein 1 Neighboring gene predicted gene 3786

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity. Maes B, et al. J Exp Med, 2023 Sep 4. PMID 37347461, Free PMC Article
    2. TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization. Li Z, et al. Biochem Biophys Res Commun, 2020 Oct 22. PMID 32807497, Free PMC Article
    3. Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10. Hammad H, et al. Nat Immunol, 2017 Mar. PMID 28068307
    4. The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice. Maes B, et al. J Allergy Clin Immunol, 2022 Apr. PMID 34506849
    5. TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells. Vanderkerken M, et al. Proc Natl Acad Sci U S A, 2020 Dec 8. PMID 33214146, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation.
      Title: The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation.
    2. Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced NAFLD development in mice.
      Title: Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced NAFLD development in mice.
    3. STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity.
      Title: STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity.
    4. TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization.
      Title: TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization.
    5. this study shows that during positive selection in the spleen, B-cell receptor signaling causes immature type 1 transitional B cells to become receptive to Notch ligands via Taok3-mediated surface expression of ADAM10
      Title: Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7)  1 citation
    • Gene trapped (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase TAO3
    Names
    thousand and one amino acid protein 3
    NP_001074777.1
    NP_001186614.1
    NP_899129.2
    XP_006530448.1
    XP_011246521.1
    XP_011246522.1
    XP_011246523.1
    XP_030110461.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081308.2 → NP_001074777.1  serine/threonine-protein kinase TAO3

      See identical proteins and their annotated locations for NP_001074777.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different segment and lacks an alternate exon in its 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AA182196, AC110234, AK042181, BM225493, BY201674, CK625948
      Consensus CDS
      CCDS39233.1
      UniProtKB/Swiss-Prot
      Q3V3B3, Q8BYC6
      UniProtKB/TrEMBL
      B2RY27
      Related
      ENSMUSP00000090565.6, ENSMUST00000092889.12
      Conserved Domains (2) summary
      PTZ00121
      Location:415 → 881
      PTZ00121; MAEBL; Provisional
      cl21453
      Location:2 → 314
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001199685.1 → NP_001186614.1  serine/threonine-protein kinase TAO3

      See identical proteins and their annotated locations for NP_001186614.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AA182196, AC110234, AK040531, AK042181, BC158072
      Consensus CDS
      CCDS39233.1
      UniProtKB/Swiss-Prot
      Q3V3B3, Q8BYC6
      UniProtKB/TrEMBL
      B2RY27
      Related
      ENSMUSP00000107609.2, ENSMUST00000111978.8
      Conserved Domains (2) summary
      PTZ00121
      Location:415 → 881
      PTZ00121; MAEBL; Provisional
      cl21453
      Location:2 → 314
      PKc_like; Protein Kinases, catalytic domain

    3. NM_183306.2 → NP_899129.2  serine/threonine-protein kinase TAO3

      See identical proteins and their annotated locations for NP_899129.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AA182196, AC110234, AK042181, BM225493, BY201674, CK625948
      Consensus CDS
      CCDS39233.1
      UniProtKB/Swiss-Prot
      Q3V3B3, Q8BYC6
      UniProtKB/TrEMBL
      B2RY27
      Related
      ENSMUSP00000136750.2, ENSMUST00000179276.8
      Conserved Domains (2) summary
      PTZ00121
      Location:415 → 881
      PTZ00121; MAEBL; Provisional
      cl21453
      Location:2 → 314
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      117258180..117413283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530385.5 → XP_006530448.1  serine/threonine-protein kinase TAO3 isoform X1

      See identical proteins and their annotated locations for XP_006530448.1

      UniProtKB/Swiss-Prot
      Q3V3B3, Q8BYC6
      UniProtKB/TrEMBL
      B2RY27
      Conserved Domains (2) summary
      PTZ00121
      Location:415 → 881
      PTZ00121; MAEBL; Provisional
      cl21453
      Location:2 → 314
      PKc_like; Protein Kinases, catalytic domain

    2. XM_011248219.4 → XP_011246521.1  serine/threonine-protein kinase TAO3 isoform X1

      See identical proteins and their annotated locations for XP_011246521.1

      UniProtKB/Swiss-Prot
      Q3V3B3, Q8BYC6
      UniProtKB/TrEMBL
      B2RY27
      Conserved Domains (2) summary
      PTZ00121
      Location:415 → 881
      PTZ00121; MAEBL; Provisional
      cl21453
      Location:2 → 314
      PKc_like; Protein Kinases, catalytic domain

    3. XM_011248220.4 → XP_011246522.1  serine/threonine-protein kinase TAO3 isoform X1

      See identical proteins and their annotated locations for XP_011246522.1

      UniProtKB/Swiss-Prot
      Q3V3B3, Q8BYC6
      UniProtKB/TrEMBL
      B2RY27
      Conserved Domains (2) summary
      PTZ00121
      Location:415 → 881
      PTZ00121; MAEBL; Provisional
      cl21453
      Location:2 → 314
      PKc_like; Protein Kinases, catalytic domain

    4. XM_011248221.4 → XP_011246523.1  serine/threonine-protein kinase TAO3 isoform X2

      UniProtKB/TrEMBL
      B2RY27
      Conserved Domains (2) summary
      PTZ00121
      Location:245 → 711
      PTZ00121; MAEBL; Provisional
      cl21453
      Location:1 → 144
      PKc_like; Protein Kinases, catalytic domain

    5. XM_030254601.2 → XP_030110461.1  serine/threonine-protein kinase TAO3 isoform X2

      UniProtKB/TrEMBL
      B2RY27
      Conserved Domains (2) summary
      PTZ00121
      Location:245 → 711
      PTZ00121; MAEBL; Provisional
      cl21453
      Location:1 → 144
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BYC6.2 GenPept UniProtKB/Swiss-Prot:Q8BYC6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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