Hpcal4 hippocalcin-like 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hpcal4provided by MGI
Official Full Name: hippocalcin-like 4provided by MGI
Primary source: MGI:MGI:2157521
See related: Ensembl:ENSMUSG00000046093 AllianceGenome:MGI:2157521
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NVP-2
Summary: Predicted to enable calcium channel regulator activity; protein C-terminus binding activity; and protein domain specific binding activity. Predicted to be involved in signal transduction. Is expressed in central nervous system; male reproductive gland or organ; and tongue. Orthologous to human HPCAL4 (hippocalcin like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 155.7), cortex adult (RPKM 149.3) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 57.4 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (123077297..123088492)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (123183504..123194699)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that the neural calcium sensor Hpcal4 likely makes a limited contribution to pain and itch processing.
Title: Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

General protein information

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Preferred Names: hippocalcin-like protein 4

Names: neural visinin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174998.4 → NP_778163.1 hippocalcin-like protein 4

See identical proteins and their annotated locations for NP_778163.1

Status: PROVISIONAL

Source sequence(s)

AL606934

Consensus CDS

CCDS18611.1

UniProtKB/Swiss-Prot

Q8BGZ1

UniProtKB/TrEMBL

B2RRY8, F2Z3Z1

Related

ENSMUSP00000051487.3, ENSMUST00000059667.9

Conserved Domains (1) summary

COG5126
Location:13 → 181

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]