Klhl4 kelch-like family member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klhl4provided by RGD
Official Full Name: kelch-like family member 4provided by RGD
Primary source: RGD:1565441
See related: Ensembl:ENSRNOG00000005215 AllianceGenome:RGD:1565441
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565441
Summary: Predicted to be located in centriolar satellite. Orthologous to human KLHL4 (kelch like family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 47.9), Brain (RPKM 42.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq31

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (83626047..83916328)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (79429193..79719482)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (86125929..86229565)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kelch-like protein 4

Names: kelch-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108244.1 → NP_001101714.1 kelch-like protein 4

See identical proteins and their annotated locations for NP_001101714.1

Status: PROVISIONAL

Source sequence(s)

CH473969

UniProtKB/TrEMBL

A6IVB0, D3ZHI3

Related

ENSRNOP00000006992.7, ENSRNOT00000006992.7

Conserved Domains (6) summary

smart00612
Location:570 → 616

Kelch; Kelch domain

PHA03098
Location:175 → 697

PHA03098; kelch-like protein; Provisional

sd00038
Location:465 → 508

Kelch; KELCH repeat [structural motif]

pfam00651
Location:171 → 275

BTB; BTB/POZ domain

pfam01344
Location:464 → 509

Kelch_1; Kelch motif

pfam07707
Location:283 → 382

BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

83626047..83916328

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099723.2 → XP_038955651.1 kelch-like protein 4 isoform X2

Conserved Domains (2) summary

PHA03098
Location:77 → 599

PHA03098; kelch-like protein; Provisional

sd00038
Location:367 → 410

Kelch; KELCH repeat [structural motif]
XM_063280013.1 → XP_063136083.1 kelch-like protein 4 isoform X3
XM_006257199.5 → XP_006257261.1 kelch-like protein 4 isoform X1

UniProtKB/TrEMBL

D3ZHI3

Conserved Domains (6) summary

smart00612
Location:564 → 610

Kelch; Kelch domain

PHA03098
Location:175 → 691

PHA03098; kelch-like protein; Provisional

sd00038
Location:459 → 502

Kelch; KELCH repeat [structural motif]

pfam00651
Location:171 → 275

BTB; BTB/POZ domain

pfam01344
Location:458 → 503

Kelch_1; Kelch motif

pfam07707
Location:283 → 382

BACK; BTB And C-terminal Kelch
XM_039099724.2 → XP_038955652.1 kelch-like protein 4 isoform X4

Conserved Domains (2) summary

PHA03098
Location:26 → 548

PHA03098; kelch-like protein; Provisional

sd00038
Location:316 → 359

Kelch; KELCH repeat [structural motif]