Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SP2 Sp2 transcription factor [ Homo sapiens (human) ]

    Gene ID: 6668, updated on 6-Sep-2021

    Summary

    Official Symbol
    SP2provided by HGNC
    Official Full Name
    Sp2 transcription factorprovided by HGNC
    Primary source
    HGNC:HGNC:11207
    See related
    Ensembl:ENSG00000167182 MIM:601801
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 4.3), spleen (RPKM 3.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SP2 in Genome Data Viewer
    Location:
    17q21.32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (47896032..47932271)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45973602..46006323)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr17.3283 Neighboring gene SP2 divergent transcript Neighboring gene SP2 antisense RNA 1 Neighboring gene pyridoxamine 5'-phosphate oxidase Neighboring gene proline rich 15 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates Sp2 transcription factor in HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003110.6NP_003101.3  transcription factor Sp2

      See identical proteins and their annotated locations for NP_003101.3

      Status: REVIEWED

      Source sequence(s)
      BC016680, BC033814, DB451570, M97190
      Consensus CDS
      CCDS11521.2
      UniProtKB/Swiss-Prot
      Q02086
      Related
      ENSP00000365931.4, ENST00000376741.5
      Conserved Domains (4) summary
      COG5048
      Location:449587
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:530549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:585607
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:571594
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      47896032..47932271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525139.2XP_011523441.1  transcription factor Sp2 isoform X4

      Conserved Domains (4) summary
      COG5048
      Location:509674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:590609
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:645667
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:631654
      zf-H2C2_2; Zinc-finger double domain
    2. XM_006722023.2XP_006722086.1  transcription factor Sp2 isoform X6

      Conserved Domains (4) summary
      COG5048
      Location:449587
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:530549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:585607
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:571594
      zf-H2C2_2; Zinc-finger double domain
    3. XM_006722026.2XP_006722089.1  transcription factor Sp2 isoform X7

      See identical proteins and their annotated locations for XP_006722089.1

      Conserved Domains (4) summary
      COG5048
      Location:442580
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:578600
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:564587
      zf-H2C2_2; Zinc-finger double domain
    4. XM_024450892.1XP_024306660.1  transcription factor Sp2 isoform X8

      Conserved Domains (4) summary
      COG5048
      Location:442580
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:578600
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:564587
      zf-H2C2_2; Zinc-finger double domain
    5. XM_006722027.2XP_006722090.1  transcription factor Sp2 isoform X7

      See identical proteins and their annotated locations for XP_006722090.1

      Conserved Domains (4) summary
      COG5048
      Location:442580
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:578600
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:564587
      zf-H2C2_2; Zinc-finger double domain
    6. XM_006722025.2XP_006722088.1  transcription factor Sp2 isoform X7

      See identical proteins and their annotated locations for XP_006722088.1

      Conserved Domains (4) summary
      COG5048
      Location:442580
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:578600
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:564587
      zf-H2C2_2; Zinc-finger double domain
    7. XM_011525142.1XP_011523444.1  transcription factor Sp2 isoform X7

      See identical proteins and their annotated locations for XP_011523444.1

      Conserved Domains (4) summary
      COG5048
      Location:442580
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:578600
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:564587
      zf-H2C2_2; Zinc-finger double domain
    8. XM_011525143.1XP_011523445.1  transcription factor Sp2 isoform X7

      See identical proteins and their annotated locations for XP_011523445.1

      Conserved Domains (4) summary
      COG5048
      Location:442580
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:578600
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:564587
      zf-H2C2_2; Zinc-finger double domain
    9. XM_017024968.1XP_016880457.1  transcription factor Sp2 isoform X7

      Conserved Domains (4) summary
      COG5048
      Location:442580
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:578600
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:564587
      zf-H2C2_2; Zinc-finger double domain
    10. XM_011525136.2XP_011523438.1  transcription factor Sp2 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:553718
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:634653
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:689711
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:675698
      zf-H2C2_2; Zinc-finger double domain
    11. XM_011525137.2XP_011523439.1  transcription factor Sp2 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:553718
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:634653
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:689711
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:675698
      zf-H2C2_2; Zinc-finger double domain
    12. XM_011525138.2XP_011523440.1  transcription factor Sp2 isoform X3

      Conserved Domains (4) summary
      COG5048
      Location:553718
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:634653
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:689711
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:675698
      zf-H2C2_2; Zinc-finger double domain
    13. XM_011525140.2XP_011523442.1  transcription factor Sp2 isoform X5

      Conserved Domains (4) summary
      COG5048
      Location:553691
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:634653
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:689711
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:675698
      zf-H2C2_2; Zinc-finger double domain
    Support Center