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    PSMG3 proteasome assembly chaperone 3 [ Homo sapiens (human) ]

    Gene ID: 84262, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PSMG3provided by HGNC
    Official Full Name
    proteasome assembly chaperone 3provided by HGNC
    Primary source
    HGNC:HGNC:22420
    See related
    Ensembl:ENSG00000157778 MIM:617528; AllianceGenome:HGNC:22420
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAC3; C7orf48
    Summary
    Enables molecular adaptor activity. Involved in chaperone-mediated protein complex assembly. Predicted to be part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bone marrow (RPKM 8.7), skin (RPKM 6.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PSMG3 in Genome Data Viewer
    Location:
    7p22.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (1567332..1570032, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (1679436..1682138, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1606968..1609668, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128653 Neighboring gene Sharpr-MPRA regulatory region 13805 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1575241-1576184 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1576185-1577128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1578073-1579015 Neighboring gene MAF bZIP transcription factor K Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25495 Neighboring gene transmembrane protein 184A Neighboring gene ReSE screen-validated silencer GRCh37_chr7:1594367-1594549 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1594659-1595459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1595460-1596259 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1599484-1599984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1599985-1600485 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr7:1606554-1607122 and GRCh37_chr7:1607123-1607691 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:1609398-1609966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25497 Neighboring gene PSMG3 antisense RNA 1 (head to head) Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1615363-1616185 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1616186-1617008 Neighboring gene uncharacterized LOC105375123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25498

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Anaplasma phagocytophilum AptA enhances the UPS, autophagy, and anti-apoptosis of host cells by PSMG3. Ma Z, et al. Int J Biol Macromol, 2021 Aug 1. PMID 34126152
    2. Crystal structure of human proteasome assembly chaperone PAC4 involved in proteasome formation. Kurimoto E, et al. Protein Sci, 2017 May. PMID 28263418, Free PMC Article
    3. PAC1-PAC2 proteasome assembly chaperone retains the core α4-α7 assembly intermediates in the cytoplasm. Wu W, et al. Genes Cells, 2018 Oct. PMID 30133132
    4. Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes. Hirano Y, et al. Mol Cell, 2006 Dec 28. PMID 17189198
    5. Affinity purification strategy to capture human endogenous proteasome complexes diversity and to identify proteasome-interacting proteins. Bousquet-Dubouch MP, et al. Mol Cell Proteomics, 2009 May. PMID 19193609, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC10911

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of protein-containing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proteasome assembly chaperone 3
    Names
    PAC-3
    hPAC3
    proteasome (prosome, macropain) assembly chaperone 3
    proteasome assembling chaperone 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134340.2 → NP_001127812.1  proteasome assembly chaperone 3

      See identical proteins and their annotated locations for NP_001127812.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BM825255, CN261807
      Consensus CDS
      CCDS5327.1
      UniProtKB/Swiss-Prot
      A4D216, A8MPW2, Q9BT73
      Related
      ENSP00000384799.3, ENST00000404674.7
      Conserved Domains (1) summary
      pfam10178
      Location:34 → 119
      PAC3; Proteasome assembly chaperone 3

    2. NM_032302.4 → NP_115678.1  proteasome assembly chaperone 3

      See identical proteins and their annotated locations for NP_115678.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC093734, BC027171, CN261807
      Consensus CDS
      CCDS5327.1
      UniProtKB/Swiss-Prot
      A4D216, A8MPW2, Q9BT73
      Related
      ENSP00000288607.2, ENST00000288607.3
      Conserved Domains (1) summary
      pfam10178
      Location:34 → 119
      PAC3; Proteasome assembly chaperone 3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      1567332..1570032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      1679436..1682138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BT73.1 GenPept UniProtKB/Swiss-Prot:Q9BT73

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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