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    Slc35a1 solute carrier family 35 (CMP-sialic acid transporter), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 24060, updated on 5-Mar-2024

    Summary

    Official Symbol
    Slc35a1provided by MGI
    Official Full Name
    solute carrier family 35 (CMP-sialic acid transporter), member 1provided by MGI
    Primary source
    MGI:MGI:1345622
    See related
    Ensembl:ENSMUSG00000028293 AllianceGenome:MGI:1345622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CST; CMP-SA-Tr; CMP-Sia-Tr
    Summary
    Enables CMP-N-acetylneuraminate transmembrane transporter activity and antiporter activity. Involved in CMP-N-acetylneuraminate transmembrane transport. Is integral component of membrane. Is expressed in several structures, including genitourinary system; liver; lung; retina; and spleen. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIf. Orthologous to human SLC35A1 (solute carrier family 35 member A1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 7.9), bladder adult (RPKM 4.2) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc35a1 in Genome Data Viewer
    Location:
    4 A5; 4 16.86 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (34663257..34688113, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (34663257..34688113, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:34497692-34497879 Neighboring gene akirin 2 Neighboring gene STARR-seq mESC enhancer starr_09912 Neighboring gene origin recognition complex, subunit 3 Neighboring gene arginyl-tRNA synthetase 2, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E6160 Neighboring gene cilia and flagella associated protein 206 Neighboring gene STARR-seq mESC enhancer starr_09914 Neighboring gene STARR-seq mESC enhancer starr_09915 Neighboring gene predicted gene 136

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    CMP-sialic acid transporter
    Names
    solute carrier family 35 member A1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424928.1NP_001411857.1  CMP-sialic acid transporter isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL928738
    2. NM_001424930.1NP_001411859.1  CMP-sialic acid transporter isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL928738
    3. NM_001424931.1NP_001411860.1  CMP-sialic acid transporter isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL928738
    4. NM_001424932.1NP_001411861.1  CMP-sialic acid transporter isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL928738
    5. NM_001424933.1NP_001411862.1  CMP-sialic acid transporter isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL928738
    6. NM_011895.4NP_036025.2  CMP-sialic acid transporter isoform 3

      See identical proteins and their annotated locations for NP_036025.2

      Status: VALIDATED

      Source sequence(s)
      AL928738
      Consensus CDS
      CCDS18030.1
      UniProtKB/Swiss-Prot
      A2AT44, Q61420
      Related
      ENSMUSP00000029970.8, ENSMUST00000029970.14
      Conserved Domains (1) summary
      pfam04142
      Location:8314
      Nuc_sug_transp; Nucleotide-sugar transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      34663257..34688113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537892.4XP_006537955.1  CMP-sialic acid transporter isoform X2

      Conserved Domains (1) summary
      pfam04142
      Location:8335
      Nuc_sug_transp; Nucleotide-sugar transporter

    RNA

    1. XR_001784138.2 RNA Sequence