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    Fbxl20 F-box and leucine-rich repeat protein 20 [ Mus musculus (house mouse) ]

    Gene ID: 72194, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Fbxl20provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 20provided by MGI
    Primary source
    MGI:MGI:1919444
    See related
    Ensembl:ENSMUSG00000020883 AllianceGenome:MGI:1919444
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Scr; Fbl2; mKIAA4147; 2610511F20Rik; 4632423N09Rik
    Summary
    Involved in regulation of protein catabolic process at presynapse, modulating synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within behavioral fear response. Located in Schaffer collateral - CA1 synapse. Is active in glutamatergic synapse. Is expressed in several structures, including adrenal gland; brain; genitourinary system; gut; and respiratory system. Orthologous to human FBXL20 (F-box and leucine rich repeat protein 20). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 14.8), thymus adult (RPKM 11.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 61.69 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97973380..98042014, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98082554..98150921, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, beta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E3013 Neighboring gene ribosomal protein L19 Neighboring gene STARR-positive B cell enhancer ABC_E9372 Neighboring gene STARR-seq mESC enhancer starr_30655 Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene STARR-seq mESC enhancer starr_30656 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97944979-97945162 Neighboring gene mediator complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E10712 Neighboring gene STARR-positive B cell enhancer mm9_chr11:98063825-98064126 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene predicted gene, 38963 Neighboring gene cyclin dependent kinase 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain. Eto F, et al. Sci Rep, 2020 May 4. PMID 32366828, Free PMC Article
    2. SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex. Koga K, et al. J Neurosci, 2017 Apr 5. PMID 28292828, Free PMC Article
    3. SCRAPPER regulates the thresholds of long-term potentiation/depression, the bidirectional synaptic plasticity in hippocampal CA3-CA1 synapses. Takagi H, et al. Neural Plast, 2012. PMID 23316391, Free PMC Article
    4. Synaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice. Yao I, et al. PLoS One, 2011 Feb 24. PMID 21390313, Free PMC Article
    5. SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Yao I, et al. Cell, 2007 Sep 7. PMID 17803915, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain.
      Title: Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain.
    2. SCRAPPER plays a critical role in the anterior cingulate cortex pre-long term potentiation as well as synaptic transmission.
      Title: SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex.
    3. SCRAPPER regulates the threshold of bidirectional synaptic plasticity and, therefore, metaplasticity.
      Title: SCRAPPER regulates the thresholds of long-term potentiation/depression, the bidirectional synaptic plasticity in hippocampal CA3-CA1 synapses.
    4. The behavioral phenotypes of Scrapper mutant mice suggest that molecular degradation conferred by SCRAPPER play important roles in hippocampal-dependent fear memory formation.
      Title: Synaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice.
    5. SCRAPPER is synapse localized E3 ubiquitin ligase which binds/ubiquinates RIM1 to regulate synaptic transmission.
      Title: SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4147

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein catabolic process at presynapse, modulating synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein catabolic process at presynapse, modulating synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of protein catabolic process at presynapse, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 20
    Names
    scrapper

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028149.1 → NP_082425.1  F-box/LRR-repeat protein 20

      See identical proteins and their annotated locations for NP_082425.1

      Status: VALIDATED

      Source sequence(s)
      AK028535, AK144786, AL591209, BB656518, CX211402
      Consensus CDS
      CCDS25339.1
      UniProtKB/Swiss-Prot
      A7YE80, Q3UMN2, Q571F7, Q8BZ95, Q9CZV8
      Related
      ENSMUSP00000099432.4, ENSMUST00000103143.10
      Conserved Domains (3) summary
      cd09293
      Location:220 → 394
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:119 → 144
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:28 → 69
      F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97973380..98042014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534299.5 → XP_006534362.1  F-box/LRR-repeat protein 20 isoform X2

      UniProtKB/Swiss-Prot
      Q9CZV8
      Conserved Domains (3) summary
      cd09293
      Location:206 → 380
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:105 → 130
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:14 → 55
      F-box-like

    2. XM_030246362.2 → XP_030102222.1  F-box/LRR-repeat protein 20 isoform X3

      Conserved Domains (2) summary
      cd09293
      Location:62 → 236
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:13 → 38
      LRR_AMN1; leucine-rich repeat [structural motif]

    3. XM_006534298.4 → XP_006534361.1  F-box/LRR-repeat protein 20 isoform X1

      See identical proteins and their annotated locations for XP_006534361.1

      UniProtKB/Swiss-Prot
      Q9CZV8
      Conserved Domains (3) summary
      cd09293
      Location:222 → 396
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:121 → 146
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:30 → 71
      F-box-like

    4. XM_036157010.1 → XP_036012903.1  F-box/LRR-repeat protein 20 isoform X3

      Conserved Domains (2) summary
      cd09293
      Location:62 → 236
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:13 → 38
      LRR_AMN1; leucine-rich repeat [structural motif]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_134030.1: Suppressed sequence

      Description
      NM_134030.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZV8.3 GenPept UniProtKB/Swiss-Prot:Q9CZV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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