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    Sfr1 SWI5 dependent recombination repair 1 [ Mus musculus (house mouse) ]

    Gene ID: 67788, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sfr1provided by MGI
    Official Full Name
    SWI5 dependent recombination repair 1provided by MGI
    Primary source
    MGI:MGI:1915038
    See related
    Ensembl:ENSMUSG00000025066 AllianceGenome:MGI:1915038
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Meir5; 6330577E15Rik
    Summary
    Predicted to enable nuclear receptor coactivator activity. Involved in double-strand break repair via homologous recombination. Located in nucleus. Part of Swi5-Sfr1 complex. Is expressed in olfactory cortex ventricular layer; pancreas epithelium; and telencephalon ventricular layer. Orthologous to human SFR1 (SWI5 dependent homologous recombination repair protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 57.4), CNS E11.5 (RPKM 54.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 D1; 19 40.41 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47720159..47724027)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47731714..47735588)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26085 Neighboring gene predicted gene, 24805 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47805577-47805764 Neighboring gene STARR-positive B cell enhancer ABC_E8756 Neighboring gene STARR-seq mESC enhancer starr_46368 Neighboring gene cilia and flagella associated protein 43 Neighboring gene microRNA 8090 Neighboring gene STARR-seq mESC enhancer starr_46371 Neighboring gene STARR-positive B cell enhancer ABC_E2529 Neighboring gene STARR-seq mESC enhancer starr_46373 Neighboring gene STARR-seq mESC enhancer starr_46374 Neighboring gene predicted gene, 30021

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination. Su GC, et al. Nucleic Acids Res, 2016 Jul 27. PMID 27131790, Free PMC Article
    2. Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex. Tsai SP, et al. Nucleic Acids Res, 2012 Aug. PMID 22492707, Free PMC Article
    3. Swi5-Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation. Lu CH, et al. Proc Natl Acad Sci U S A, 2018 Oct 23. PMID 30297419, Free PMC Article
    4. Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease. Rousseaux MW, et al. Proc Natl Acad Sci U S A, 2012 Sep 25. PMID 23019375, Free PMC Article
    5. Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. Akamatsu Y, et al. PLoS Genet, 2010 Oct 14. PMID 20976249, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Swi5-Sfr1 (S5S1) stimulates Rad51-mediated homologous recombination.
      Title: Swi5-Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation.
    2. Our results thus help establish the functional relevance of the trimeric RAD51-SWI5-SFR1 complex and provide insights into the mechanistic underpinnings of homology-directed DNA repair in mammalian cells.
      Title: Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination.
    3. Biophysical evidence that the mouse Swi5-Sfr1 complex has a 1:1 stoichiometry.
      Title: Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex.
    4. Data show that Swi5-Sfr1 is a newly identified complex required for genomic integrity in mammalian cells with a specific role in the repair of DNA strand breaks.
      Title: Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to estrogen stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Swi5-Sfr1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Swi5-Sfr1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Swi5-Sfr1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    swi5-dependent recombination DNA repair protein 1 homolog
    Names
    DNA repair protein Sfr1
    meiosis protein 5 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026377.2 → NP_080653.2  swi5-dependent recombination DNA repair protein 1 homolog

      See identical proteins and their annotated locations for NP_080653.2

      Status: VALIDATED

      Source sequence(s)
      AK011531, AK146810, AV335878
      Consensus CDS
      CCDS38019.1
      UniProtKB/Swiss-Prot
      Q3TH62, Q3TI03, Q3TJK0, Q3UIQ6, Q8BP27, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4
      UniProtKB/TrEMBL
      E3WH30
      Related
      ENSMUSP00000096954.5, ENSMUST00000099353.6
      Conserved Domains (1) summary
      pfam10376
      Location:108 → 310
      Mei5; Double-strand recombination repair protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      47720159..47724027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527308.4 → XP_006527371.1  swi5-dependent recombination DNA repair protein 1 homolog isoform X1

      UniProtKB/TrEMBL
      E3WH30
      Conserved Domains (1) summary
      pfam10376
      Location:96 → 298
      Mei5; Double-strand recombination repair protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BP27.2 GenPept UniProtKB/Swiss-Prot:Q8BP27

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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