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    Milr1 mast cell immunoglobulin like receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 380732, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Milr1provided by MGI
    Official Full Name
    mast cell immunoglobulin like receptor 1provided by MGI
    Primary source
    MGI:MGI:2685731
    See related
    Ensembl:ENSMUSG00000040528 AllianceGenome:MGI:2685731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm885; Mca32; Allergin-1
    Summary
    Predicted to enable transmembrane signaling receptor activity. Involved in mast cell degranulation and negative regulation of mast cell activation. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in adrenal gland; stomach; and testis. Orthologous to human MILR1 (mast cell immunoglobulin like receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 E1; 11 70.0 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106641472..106659620)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106750646..106768794)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene platelet/endothelial cell adhesion molecule 1 Neighboring gene STARR-positive B cell enhancer ABC_E1150 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106535909-106536110 Neighboring gene STARR-seq mESC enhancer starr_30943 Neighboring gene STARR-seq mESC enhancer starr_30946 Neighboring gene predicted gene, 51950 Neighboring gene STARR-positive B cell enhancer ABC_E10724 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106611859-106612059 Neighboring gene STARR-positive B cell enhancer ABC_E5289 Neighboring gene STARR-positive B cell enhancer ABC_E4006 Neighboring gene STARR-seq mESC enhancer starr_30947 Neighboring gene polymerase (DNA directed), gamma 2, accessory subunit Neighboring gene STARR-seq mESC enhancer starr_30948 Neighboring gene microRNA 3064 Neighboring gene DEAD box helicase 5 Neighboring gene centrosomal protein 95

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An inhibitory immunoreceptor, Allergin-1, suppresses FITC-induced type 2 contact hypersensitivity. Almeida MS, et al. Biochem Biophys Res Commun, 2021 Nov 19. PMID 34601199
    2. Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice. Lin YH, et al. Int Immunol, 2020 Mar 7. PMID 31793637
    3. Allergy inhibitory receptor-1 inhibits autoantibody production via upregulation of apoptotic debris clearance by macrophages. Iizuka A, et al. Int J Rheum Dis, 2018 Dec. PMID 30556363
    4. Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis. Tsurusaki S, et al. Int Immunol, 2016 Dec. PMID 27932517
    5. Allergin-1 Immunoreceptor Suppresses House Dust Mite-Induced Allergic Airway Inflammation. Miki H, et al. J Immunol, 2020 Feb 15. PMID 31900344

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice.
      Title: Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice.
    2. Allergin-1 Immunoreceptor Suppresses House Dust Mite-Induced Allergic Airway Inflammation.
      Title: Allergin-1 Immunoreceptor Suppresses House Dust Mite-Induced Allergic Airway Inflammation.
    3. Allergin-1 might play an inhibitory role in autoantibody production via upregulation of macrophage phagocytosis.
      Title: Allergy inhibitory receptor-1 inhibits autoantibody production via upregulation of apoptotic debris clearance by macrophages.
    4. The results suggest that Allergin-1 on skin MCs suppresses TLR2-induced dermatitis.
      Title: Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis.
    5. It is a immunoglobulin-like receptor which regulates the activation of mast cell.(review)
      Title: [Immunoglobulin-like receptor, allergin-1 regulates the activation of mast cells].
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Clone Names

    • MGC179156

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mast cell activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    allergin-1
    Names
    allergy inhibitory receptor 1
    mast cell Ag-32
    mast cell antigen 32
    surface protein MCA-32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033435.3 → NP_001028607.1  allergin-1 isoform a precursor

      See identical proteins and their annotated locations for NP_001028607.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK136488, AK171381, BY197245
      Consensus CDS
      CCDS25560.1
      UniProtKB/Swiss-Prot
      B2RTB7, B7ZP18, D6RUW9, Q3TB92, Q3TC23, Q3TDY5, Q3U5M7, Q3U9F5
      Related
      ENSMUSP00000083538.4, ENSMUST00000086353.11
      Conserved Domains (1) summary
      smart00410
      Location:62 → 131
      IG_like; Immunoglobulin like

    2. NM_001271372.1 → NP_001258301.1  allergin-1 isoform b precursor

      See identical proteins and their annotated locations for NP_001258301.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AK171381, BY197245
      Consensus CDS
      CCDS70334.1
      UniProtKB/TrEMBL
      A0A140T8Q6
      Related
      ENSMUSP00000102406.3, ENSMUST00000106794.9
      Conserved Domains (2) summary
      smart00410
      Location:62 → 131
      IG_like; Immunoglobulin like
      pfam13927
      Location:54 → 122
      Ig_3; Immunoglobulin domain

    3. NM_001271373.1 → NP_001258302.1  allergin-1 isoform c precursor

      See identical proteins and their annotated locations for NP_001258302.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon and lacks an exon, compared to variant 1. These changes result in a frameshift. The encoded isoform (c) has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK171381, BC145582, BY197245
      Consensus CDS
      CCDS70333.1
      UniProtKB/TrEMBL
      B7ZP19
      Related
      ENSMUSP00000138617.2, ENSMUST00000182896.8
      Conserved Domains (2) summary
      smart00410
      Location:62 → 131
      IG_like; Immunoglobulin like
      pfam13927
      Location:54 → 122
      Ig_3; Immunoglobulin domain

    4. NM_001271374.1 → NP_001258303.1  allergin-1 isoform d precursor

      See identical proteins and their annotated locations for NP_001258303.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (d) is shorter than isoform a. Variants 4 and 5 encode the same isoform (d).
      Source sequence(s)
      AK171381, BC145580, BY197245
      Consensus CDS
      CCDS70335.1
      UniProtKB/Swiss-Prot
      Q3TB92
      Related
      ENSMUSP00000138678.2, ENSMUST00000182908.8
      Conserved Domains (1) summary
      smart00410
      Location:62 → 131
      IG_like; Immunoglobulin like

    5. NM_001271375.1 → NP_001258304.1  allergin-1 isoform d precursor

      See identical proteins and their annotated locations for NP_001258304.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon and differs in the 3' UTR, compared to variant 1. The encoded isoform (d) is shorter than isoform a. Variants 4 and 5 encode the same isoform (d).
      Source sequence(s)
      AL603664
      Consensus CDS
      CCDS70335.1
      UniProtKB/Swiss-Prot
      Q3TB92
      Related
      ENSMUSP00000138513.2, ENSMUST00000183111.8
      Conserved Domains (1) summary
      smart00410
      Location:62 → 131
      IG_like; Immunoglobulin like

    RNA

    1. NR_073165.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains two alternate internal exons and differs at the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK137500, AL603664, BY197245
      Related
      ENSMUST00000182023.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      106641472..106659620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249104.3 → XP_011247406.1  allergin-1 isoform X1

      See identical proteins and their annotated locations for XP_011247406.1

      UniProtKB/Swiss-Prot
      B2RTB7, B7ZP18, D6RUW9, Q3TB92, Q3TC23, Q3TDY5, Q3U5M7, Q3U9F5
      Conserved Domains (1) summary
      smart00410
      Location:62 → 131
      IG_like; Immunoglobulin like

    2. XM_036156820.1 → XP_036012713.1  allergin-1 isoform X4

      UniProtKB/TrEMBL
      A0A0B4J1N6
      Conserved Domains (1) summary
      smart00409
      Location:62 → 131
      IG; Immunoglobulin

    3. XM_017314633.3 → XP_017170122.1  allergin-1 isoform X3

      Conserved Domains (1) summary
      smart00409
      Location:62 → 131
      IG; Immunoglobulin

    4. XM_006533649.5 → XP_006533712.1  allergin-1 isoform X2

      See identical proteins and their annotated locations for XP_006533712.1

      UniProtKB/Swiss-Prot
      Q3TB92
      Conserved Domains (1) summary
      smart00410
      Location:62 → 131
      IG_like; Immunoglobulin like

    5. XM_006533648.5 → XP_006533711.1  allergin-1 isoform X1

      See identical proteins and their annotated locations for XP_006533711.1

      UniProtKB/Swiss-Prot
      B2RTB7, B7ZP18, D6RUW9, Q3TB92, Q3TC23, Q3TDY5, Q3U5M7, Q3U9F5
      Related
      ENSMUSP00000138742.2, ENSMUST00000147326.9
      Conserved Domains (1) summary
      smart00410
      Location:62 → 131
      IG_like; Immunoglobulin like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TB92.2 GenPept UniProtKB/Swiss-Prot:Q3TB92

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