Fut1 fucosyltransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fut1provided by MGI
Official Full Name: fucosyltransferase 1provided by MGI
Primary source: MGI:MGI:109375
See related: Ensembl:ENSMUSG00000008461 AllianceGenome:MGI:109375
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MFUT-1
Summary: This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is required for the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene impairs development of the olfactory nerve and maturation of the glomerular layer of the main olfactory bulb. Alternative splicing results in multiple transcript variants which encode distinct isoforms. [provided by RefSeq, Dec 2012]
Expression: Biased expression in genital fat pad adult (RPKM 6.7), testis adult (RPKM 1.0) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.39 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (45266862..45270483)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45617606..45621059)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis.
Title: FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis.
The Eyelid Meibomian Gland Deficiency in Fucosyltransferase 1 Knockout Mice.
Title: The Eyelid Meibomian Gland Deficiency in Fucosyltransferase 1 Knockout Mice.
Intestinal alpha1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice.
Title: Intestinal α1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice.
Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma.
Title: Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma.
miR-339-5p downregulation contributes to Taxol resistance in small-cell lung cancer by targeting FUT1.
Title: miR-339-5p downregulation contributes to Taxol resistance in small-cell lung cancer by targeting α1,2-fucosyltransferase 1.
Fut1 plays an important role in regulating angiogenesis and ICAM-1 expression in inflammatory arthritis.
Title: A key role for Fut1-regulated angiogenesis and ICAM-1 expression in K/BxN arthritis.
We found that Fut1 mRNA and Fut4 mRNA were upregulated, while Fut2 mRNA and Fut9 mRNA were downregulated by androgen in the caput epididymis.
Title: Different effects of androgen on the expression of Fut1, Fut2, Fut4 and Fut9 in male mouse reproductive tract.
fucosyltransferase (Fut)-deficient (Fut1, Fut2 and Fut4) mice which lack LeX or LeY antigen are still fertile.
Title: Biosynthesis and distribution of Lewis X- and Lewis Y-containing glycoproteins in the murine male reproductive system.
These results indicate that Fut2-mediated fucosylated epithelial cells (F-ECs) share M cell-related fucosylated molecules but maintain distinctive EC characteristics, Fut1 is, therefore, a reliable marker for M cells.
Title: Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress.
Vasculogenesis was the most clearly affected by FUT1 expression, suggesting that tumor angiomorphogenesis may depend on E-selectin-mediated interaction between HCC and endothelial cells, the inhibition of which remarkably retards tumor growth.
Title: Introducing alpha(1,2)-linked fucose into hepatocarcinoma cells inhibits vasculogenesis and tumor growth.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489054

06.MMHAP14FLB3.seq (e-PCR)
- UniSTS:122845

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-(1,2)-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables fucosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables galactoside 2-alpha-L-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactoside 2-alpha-L-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fucosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fucosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in fucosylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in olfactory bulb development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligosaccharide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galactoside alpha-(1,2)-fucosyltransferase 1

Names: GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1; H transferase; alpha(1,2)FT 1; beta-galactoside alpha-1,2-fucosyltransferase; galactoside 2-alpha-L-fucosyltransferase 1; type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1; type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1

NP_001258910.1

EC 2.4.1.344

EC 2.4.1.69

NP_032077.2

EC 2.4.1.344

EC 2.4.1.69

XP_036008571.1

EC 2.4.1.344

EC 2.4.1.69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271981.1 → NP_001258910.1 galactoside alpha-(1,2)-fucosyltransferase 1 isoform 2

See identical proteins and their annotated locations for NP_001258910.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site at the 5' end of the coding exon and uses an in-frame downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC149057, AK137638, BC109145

Consensus CDS

CCDS85303.1

UniProtKB/TrEMBL

Q32MG3, Q9JL28

Related

ENSMUSP00000147274.2, ENSMUST00000209379.2

Conserved Domains (1) summary

pfam01531
Location:18 → 300

Glyco_transf_11; Glycosyl transferase family 11
NM_008051.6 → NP_032077.2 galactoside alpha-(1,2)-fucosyltransferase 1 isoform 1

See identical proteins and their annotated locations for NP_032077.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC149057, AK137638

Consensus CDS

CCDS21254.1

UniProtKB/Swiss-Prot

O09160, P97327

UniProtKB/TrEMBL

Q920W5, Q9JL28

Related

ENSMUSP00000008605.6, ENSMUST00000008605.6

Conserved Domains (1) summary

pfam01531
Location:39 → 355

Glyco_transf_11; Glycosyl transferase family 11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

45266862..45270483

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152678.1 → XP_036008571.1 galactoside alpha-(1,2)-fucosyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

O09160, P97327

UniProtKB/TrEMBL

Q920W5, Q9JL28

Conserved Domains (1) summary

pfam01531
Location:39 → 355

Glyco_transf_11; Glycosyl transferase family 11