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    Tsacc TSSK6 activating co-chaperone [ Mus musculus (house mouse) ]

    Gene ID: 76927, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tsaccprovided by MGI
    Official Full Name
    TSSK6 activating co-chaperoneprovided by MGI
    Primary source
    MGI:MGI:1924177
    See related
    Ensembl:ENSMUSG00000010538 AllianceGenome:MGI:1924177
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SIP; 1700021C14Rik
    Summary
    Predicted to enable several functions, including Hsp70 protein binding activity; chaperone binding activity; and protein kinase inhibitor activity. Predicted to act upstream of or within positive regulation of protein kinase activity. Located in cytoplasm. Orthologous to human TSACC (TSSK6 activating cochaperone). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 186.4) and genital fat pad adult (RPKM 3.2) See more
    Orthologs
    human all
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    Genomic context

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    See Tsacc in Genome Data Viewer
    Location:
    3 F1; 3 38.79 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88190059..88204306, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88282752..88296999, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3764 Neighboring gene microRNA 9b-1 Neighboring gene microRNA 9-1 Neighboring gene STARR-seq mESC enhancer starr_08177 Neighboring gene VISTA enhancer mm474 Neighboring gene Rhesus blood group-associated B glycoprotein Neighboring gene STARR-seq mESC enhancer starr_08178 Neighboring gene STARR-seq mESC enhancer starr_08179 Neighboring gene chaperonin containing TCP1 subunit 3 Neighboring gene glycosylated lysosomal membrane protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinase. Jha KN, et al. J Biol Chem, 2010 Nov 5. PMID 20829357, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

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    Homology

    Clone Names

    • MGC130252

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TSSK6-activating co-chaperone protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357024.1 → NP_001343953.1  TSSK6-activating co-chaperone protein

      Status: VALIDATED

      Source sequence(s)
      AC044864, BF152860
      Consensus CDS
      CCDS17467.1
      UniProtKB/Swiss-Prot
      Q9DA44
      Related
      ENSMUSP00000103180.4, ENSMUST00000107556.10
      Conserved Domains (1) summary
      pfam15836
      Location:1 → 124
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    2. NM_029801.3 → NP_084077.1  TSSK6-activating co-chaperone protein

      See identical proteins and their annotated locations for NP_084077.1

      Status: VALIDATED

      Source sequence(s)
      AC044864, AK006195
      Consensus CDS
      CCDS17467.1
      UniProtKB/Swiss-Prot
      Q9DA44
      Related
      ENSMUSP00000010682.4, ENSMUST00000010682.4
      Conserved Domains (1) summary
      pfam15836
      Location:1 → 124
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88190059..88204306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252882.2 → XP_030108742.1  TSSK6-activating co-chaperone protein isoform X1

      Conserved Domains (1) summary
      pfam15836
      Location:1 → 149
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    2. XM_030252883.2 → XP_030108743.1  TSSK6-activating co-chaperone protein isoform X2

      Conserved Domains (1) summary
      pfam15836
      Location:29 → 146
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DA44.1 GenPept UniProtKB/Swiss-Prot:Q9DA44

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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