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    Actr1a ARP1 actin-related protein 1A, centractin alpha [ Mus musculus (house mouse) ]

    Gene ID: 54130, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Actr1aprovided by MGI
    Official Full Name
    ARP1 actin-related protein 1A, centractin alphaprovided by MGI
    Primary source
    MGI:MGI:1858964
    See related
    Ensembl:ENSMUSG00000025228 AllianceGenome:MGI:1858964
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arp1; actin-RPV; alpha-Arp1
    Summary
    Predicted to enable ATP binding activity. Located in myelin sheath. Is expressed in ganglia and trigeminal nerve. Orthologous to human ACTR1A (actin related protein 1A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 78.3), CNS E18 (RPKM 74.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C3; 19 38.84 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46365252..46384180, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46376813..46395741, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310034G01 gene Neighboring gene major facilitator superfamily domain containing 13a Neighboring gene predicted gene, 24610 Neighboring gene STARR-positive B cell enhancer ABC_E3253 Neighboring gene STARR-positive B cell enhancer ABC_E7668 Neighboring gene STARR-positive B cell enhancer ABC_E1528 Neighboring gene SUFU negative regulator of hedgehog signaling Neighboring gene STARR-positive B cell enhancer ABC_E4288 Neighboring gene STARR-positive B cell enhancer ABC_E5708 Neighboring gene STARR-seq mESC enhancer starr_46309 Neighboring gene STARR-positive B cell enhancer ABC_E268 Neighboring gene STARR-seq mESC enhancer starr_46312 Neighboring gene tripartite motif-containing 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Primary structure of mouse actin-related protein 1 (Arp1) and its tissue expression. Kusano K, et al. Zoolog Sci, 1997 Feb. PMID 9200982
    2. Beta-III spectrin mutation L253P associated with spinocerebellar ataxia type 5 interferes with binding to Arp1 and protein trafficking from the Golgi. Clarkson YL, et al. Hum Mol Genet, 2010 Sep 15. PMID 20603325, Free PMC Article
    3. Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts. Yogo K, et al. Endocrinology, 2006 Jul. PMID 16601135
    4. Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain. Lee M, et al. J Cell Biol, 2020 Feb 3. PMID 31910261, Free PMC Article
    5. Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1. Eckley DM, et al. Mol Biol Cell, 2003 Jul. PMID 12857853, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Beta-III spectrin mutation L253P interferes with binding to Arp1 and protein trafficking from the Golgi.
      Title: Beta-III spectrin mutation L253P associated with spinocerebellar ataxia type 5 interferes with binding to Arp1 and protein trafficking from the Golgi.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in COPI-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in manchette ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myelin sheath HDA PubMed 

    General protein information

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    Preferred Names
    alpha-centractin
    Names
    ARP1 actin-related protein 1 homolog A, centractin alpha
    actin-related protein 1 alpha
    centrosome-associated actin homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365070.1 → NP_001351999.1  alpha-centractin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK019518, BY794369, CD776146
      Consensus CDS
      CCDS89411.1
      UniProtKB/TrEMBL
      A0A494BB86
      Related
      ENSMUSP00000158413.2, ENSMUST00000237742.2
      Conserved Domains (1) summary
      cl17037
      Location:5 → 307
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. NM_016860.2 → NP_058556.1  alpha-centractin isoform 1

      See identical proteins and their annotated locations for NP_058556.1

      Status: VALIDATED

      Source sequence(s)
      AB010297, BY794369, CD776146
      Consensus CDS
      CCDS29878.1
      UniProtKB/Swiss-Prot
      P61164, Q3TJF9
      Related
      ENSMUSP00000039844.5, ENSMUST00000040270.6
      Conserved Domains (1) summary
      cl17037
      Location:5 → 376
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      46365252..46384180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61164.1 GenPept UniProtKB/Swiss-Prot:P61164

    Gene LinkOut

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