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    Raet1e retinoic acid early transcript 1E [ Mus musculus (house mouse) ]

    Gene ID: 379043, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Raet1eprovided by MGI
    Official Full Name
    retinoic acid early transcript 1Eprovided by MGI
    Primary source
    MGI:MGI:2675273
    See related
    Ensembl:ENSMUSG00000053219 AllianceGenome:MGI:2675273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables natural killer cell lectin-like receptor binding activity. Acts upstream of or within T cell mediated cytotoxicity. Predicted to be located in plasma membrane. Predicted to be anchored component of membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in embryo endoderm and midgut. Orthologous to human RAET1E (retinoic acid early transcript 1E) and RAET1G (retinoic acid early transcript 1G). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver adult (RPKM 1.1), bladder adult (RPKM 0.9) and 21 other tissues See more
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    Genomic context

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    Location:
    10 A3; 10 9.89 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (22034441..22059820)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (22158542..22189697)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E030030I06 gene Neighboring gene aldo-keto reductase family 1, member B3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26015 Neighboring gene predicted gene 4895 Neighboring gene predicted gene, 26740 Neighboring gene UL16 binding protein 1 pseudogene Neighboring gene histocompatibility 60b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8(+) T-Cell Numbers. Trembath AP, et al. Diabetes, 2020 Aug. PMID 32535552, Free PMC Article
    2. RAE-1 expression is induced during experimental autoimmune encephalomyelitis and is correlated with microglia cell proliferation. Djelloul M, et al. Brain Behav Immun, 2016 Nov. PMID 27444966
    3. Endothelial cells express NKG2D ligands and desensitize antitumor NK responses. Thompson TW, et al. Elife, 2017 Dec 12. PMID 29231815, Free PMC Article
    4. CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1ε transgenic mice. Lin Z, et al. Immunology, 2014 Mar. PMID 24708417, Free PMC Article
    5. RAE1ε ligand expressed on pancreatic islets recruits NKG2D receptor-expressing cytotoxic T cells independent of T cell receptor recognition. Markiewicz MA, et al. Immunity, 2012 Jan 27. PMID 22244846, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study reports that retinoic acid early induced transcript-1-d and retinoic acid early induced transcript-1-e (Raet1) genes are induced early upon experimental autoimmune encephalomyelitis onset and reach a maximal expression at the peak of the pathology. Study also shows that macrophages as well as microglia, are cellular sources of Raet1 transcripts.
      Title: RAE-1 expression is induced during experimental autoimmune encephalomyelitis and is correlated with microglia cell proliferation.
    2. CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1epsilon transgenic mice.
      Title: CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1ε transgenic mice.
    3. Reveal Raet1e, a major histocompatibility complex class 1-like molecule expressed in lesional aortic endothelial cells and macrophage-rich regions, as a novel atherosclerosis gene.
      Title: Altered expression of Raet1e, a major histocompatibility complex class 1-like molecule, underlies the atherosclerosis modifier locus Ath11 10b.
    4. Raet1e genes are directly transcriptionally activated by E2F family transcription factors, which play a central role in regulating cell cycle entry.
      Title: RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry.
    5. RAE1 expression was sufficient to induce the recruitment of adoptively transferred CTLs to islets.
      Title: RAE1ε ligand expressed on pancreatic islets recruits NKG2D receptor-expressing cytotoxic T cells independent of T cell receptor recognition.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables natural killer cell lectin-like receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables natural killer cell lectin-like receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables natural killer cell lectin-like receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    retinoic acid early-inducible protein 1-epsilon
    Names
    Rae-1 epsilon

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359808.1 → NP_001346737.1  retinoic acid early-inducible protein 1-epsilon precursor

      Status: VALIDATED

      Source sequence(s)
      AK012289, AK131854, FJ594067
      Consensus CDS
      CCDS35865.1
      UniProtKB/Swiss-Prot
      A2RSZ5, Q9CZQ6
      UniProtKB/TrEMBL
      D7F2B6
      Related
      ENSMUSP00000138022.2, ENSMUST00000181645.8
      Conserved Domains (1) summary
      cl08246
      Location:31 → 202
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    2. NM_001359809.1 → NP_001346738.1  retinoic acid early-inducible protein 1-epsilon precursor

      Status: VALIDATED

      Source sequence(s)
      AK012289, AK131854, FJ594067
      Consensus CDS
      CCDS35865.1
      UniProtKB/Swiss-Prot
      A2RSZ5, Q9CZQ6
      UniProtKB/TrEMBL
      D7F2B6
      Conserved Domains (1) summary
      cl08246
      Location:31 → 202
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    3. NM_198193.3 → NP_937836.1  retinoic acid early-inducible protein 1-epsilon precursor

      See identical proteins and their annotated locations for NP_937836.1

      Status: VALIDATED

      Source sequence(s)
      AK012289, CV561218, FJ594067
      Consensus CDS
      CCDS35865.1
      UniProtKB/Swiss-Prot
      A2RSZ5, Q9CZQ6
      UniProtKB/TrEMBL
      D7F2B6
      Related
      ENSMUSP00000066627.5, ENSMUST00000065527.11
      Conserved Domains (1) summary
      cl08246
      Location:31 → 202
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      22034441..22059820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512780.3 → XP_006512843.1  retinoic acid early-inducible protein 1-epsilon isoform X1

      See identical proteins and their annotated locations for XP_006512843.1

      UniProtKB/Swiss-Prot
      A2RSZ5, Q9CZQ6
      UniProtKB/TrEMBL
      D7F2B6
      Conserved Domains (1) summary
      cl08246
      Location:31 → 202
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    2. XM_011243179.1 → XP_011241481.1  retinoic acid early-inducible protein 1-epsilon isoform X1

      See identical proteins and their annotated locations for XP_011241481.1

      UniProtKB/Swiss-Prot
      A2RSZ5, Q9CZQ6
      UniProtKB/TrEMBL
      D7F2B6
      Conserved Domains (1) summary
      cl08246
      Location:31 → 202
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    3. XM_006512782.2 → XP_006512845.1  retinoic acid early-inducible protein 1-epsilon isoform X1

      See identical proteins and their annotated locations for XP_006512845.1

      UniProtKB/Swiss-Prot
      A2RSZ5, Q9CZQ6
      UniProtKB/TrEMBL
      D7F2B6
      Related
      ENSMUSP00000136032.2, ENSMUST00000178026.2
      Conserved Domains (1) summary
      cl08246
      Location:31 → 202
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZQ6.1 GenPept UniProtKB/Swiss-Prot:Q9CZQ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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