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    Nolc1 nucleolar and coiled-body phosphoprotein 1 [ Mus musculus (house mouse) ]

    Gene ID: 70769, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Nolc1provided by MGI
    Official Full Name
    nucleolar and coiled-body phosphoprotein 1provided by MGI
    Primary source
    MGI:MGI:1918019
    See related
    Ensembl:ENSMUSG00000015176 AllianceGenome:MGI:1918019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P130; NOPP130; NOPP140
    Summary
    Predicted to enable several functions, including TFIIB-class transcription factor binding activity; snoRNA binding activity; and snoRNP binding activity. Acts upstream of or within nucleolus organization. Located in Cajal body and nucleolus. Is expressed in 1-cell stage embryo; cerebral cortex ventricular layer; and cortical plate. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 39.7), liver E14.5 (RPKM 31.2) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C3; 19 38.75 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46064286..46073982)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46075847..46085543)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46294 Neighboring gene STARR-positive B cell enhancer ABC_E5707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:46114769-46114954 Neighboring gene STARR-positive B cell enhancer ABC_E1527 Neighboring gene LIM domain binding 1 Neighboring gene STARR-positive B cell enhancer ABC_E7666 Neighboring gene peroxisome proliferative activated receptor, gamma, coactivator-related 1 Neighboring gene STARR-positive B cell enhancer ABC_E11034 Neighboring gene STARR-positive B cell enhancer ABC_E101 Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene paired-like homeodomain transcription factor 3 Neighboring gene golgi-specific brefeldin A-resistance factor 1 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus. Yuan F, et al. Aging Cell, 2017 Aug. PMID 28493459, Free PMC Article
    2. Three-Dimensional Distribution of UBF and Nopp140 in Relationship to Ribosomal DNA Transcription During Mouse Preimplantation Development. Koné MC, et al. Biol Reprod, 2016 Apr. PMID 26984997
    3. NOLC1, an enhancer of nasopharyngeal carcinoma progression, is essential for TP53 to regulate MDM2 expression. Hwang YC, et al. Am J Pathol, 2009 Jul. PMID 19541936, Free PMC Article
    4. Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product. Tucker KE, et al. J Cell Biol, 2001 Jul 23. PMID 11470819, Free PMC Article
    5. Phosphorylation of proteins by inositol pyrophosphates. Saiardi A, et al. Science, 2004 Dec 17. PMID 15604408

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus.
      Title: Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus.
    2. UBF and Nopp140 dynamic redistribution between the two-cell and blastocyst stages (time of implantation) is correlated with morphological and structural modifications that occur in embryonic nucleolar compartments.
      Title: Three-Dimensional Distribution of UBF and Nopp140 in Relationship to Ribosomal DNA Transcription During Mouse Preimplantation Development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • mKIAA0035, 3230402K17Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables TFIIB-class transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables box C/D methylation guide snoRNP complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables box C/D sno(s)RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables box H/ACA snoRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables box H/ACA snoRNP complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular function inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in box H/ACA sno(s)RNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in neural crest cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural crest formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleolus organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of box C/D methylation guide snoRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of box H/ACA snoRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small nuclear ribonucleoprotein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleolar and coiled-body phosphoprotein 1
    Names
    140 kDa nucleolar phosphoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039351.2 → NP_001034440.1  nucleolar and coiled-body phosphoprotein 1 isoform B

      See identical proteins and their annotated locations for NP_001034440.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the central coding region, compared to variant 3. The encoded isoform (B) is shorter, compared to isoform C.
      Source sequence(s)
      AK029150, AK147118, BE992617, BY031361
      Consensus CDS
      CCDS89406.1
      UniProtKB/TrEMBL
      A0A286YDA2, A0A286YDV7
      Related
      ENSMUSP00000153329.2, ENSMUST00000223728.2
      Conserved Domains (1) summary
      pfam05022
      Location:625 → 691
      SRP40_C; SRP40, C-terminal domain

    2. NM_001039352.2 → NP_001034441.1  nucleolar and coiled-body phosphoprotein 1 isoform C

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (C).
      Source sequence(s)
      AK034817, BE992617, BY031361, CF750495
      Consensus CDS
      CCDS38006.1
      UniProtKB/Swiss-Prot
      E9Q5C9, Q3TKZ9, Q3U6W2, Q3UBB6, Q3UI16, Q6ZQK6, Q8CE21
      UniProtKB/TrEMBL
      A0A286YDV7
      Related
      ENSMUSP00000128331.2, ENSMUST00000165017.2
      Conserved Domains (1) summary
      pfam05022
      Location:627 → 693
      SRP40_C; SRP40, C-terminal domain

    3. NM_001039353.2 → NP_001034442.1  nucleolar and coiled-body phosphoprotein 1 isoform D

      See identical proteins and their annotated locations for NP_001034442.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region, compared to variant 3. The encoded isoform (D) is shorter, compared to isoform C.
      Source sequence(s)
      AK034817, AK147118, BE992617, BY031361
      UniProtKB/TrEMBL
      A0A286YDV7
      Conserved Domains (1) summary
      pfam05022
      Location:626 → 692
      SRP40_C; SRP40, C-terminal domain

    4. NM_053086.3 → NP_444316.2  nucleolar and coiled-body phosphoprotein 1 isoform A

      See identical proteins and their annotated locations for NP_444316.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the central coding region, compared to variant 3. The encoded isoform (A) is shorter, compared to isoform C.
      Source sequence(s)
      AK147118, AK166753, BE992617, BY031361
      Consensus CDS
      CCDS89405.1
      UniProtKB/TrEMBL
      A0A286YDT3, A0A286YDV7
      Related
      ENSMUSP00000153545.2, ENSMUST00000225780.2
      Conserved Domains (1) summary
      pfam05022
      Location:626 → 692
      SRP40_C; SRP40, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      46064286..46073982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q5C9.1 GenPept UniProtKB/Swiss-Prot:E9Q5C9

    Gene LinkOut

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