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    Atp6v0c ATPase, H+ transporting, lysosomal V0 subunit C [ Mus musculus (house mouse) ]

    Gene ID: 11984, updated on 16-Apr-2024

    Summary

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    Official Symbol
    Atp6v0cprovided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V0 subunit Cprovided by MGI
    Primary source
    MGI:MGI:88116
    See related
    Ensembl:ENSMUSG00000024121 AllianceGenome:MGI:88116
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atpl; PL16; VATL; Vma3; Atp6c; Atp6l; Atp6c2; Atpl-rs1
    Summary
    Predicted to enable P-type proton-exporting transporter activity and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of autophagic cell death; positive regulation of ERK1 and ERK2 cascade; and positive regulation of Wnt signaling pathway. Predicted to act upstream of or within lysosomal lumen acidification. Predicted to be located in Golgi apparatus; lysosome; and synaptic vesicle. Predicted to be part of vacuolar proton-transporting V-type ATPase complex. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 768.5), adrenal adult (RPKM 629.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 12.29 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24382839..24388652, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24163865..24169678, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene 3-phosphoinositide dependent protein kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1935 Neighboring gene predicted gene, 33409 Neighboring gene STARR-seq mESC enhancer starr_42075 Neighboring gene amidohydrolase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E8658 Neighboring gene TBC1 domain family, member 24 Neighboring gene STARR-seq mESC enhancer starr_42079 Neighboring gene STARR-positive B cell enhancer ABC_E2472 Neighboring gene netrin 3 Neighboring gene tubulin epsilon and delta complex 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Acidic endomembrane organelles are required for mouse postimplantation development. Sun-Wada G, et al. Dev Biol, 2000 Dec 15. PMID 11112332
    2. Targeted disruption of the gene encoding the proteolipid subunit of mouse vacuolar H(+)-ATPase leads to early embryonic lethality. Inoue H, et al. Biochim Biophys Acta, 1999 Nov 10. PMID 10556625
    3. Molecular cloning of cDNA encoding the 16 KDa subunit of vacuolar H(+)-ATPase from mouse cerebellum. Hanada H, et al. Biochem Biophys Res Commun, 1991 May 15. PMID 1828149
    4. High glucose disrupts autophagy lysosomal pathway in gingival epithelial cells via ATP6V0C. Huang X, et al. J Periodontol, 2020 May. PMID 31471894
    5. Mouse proton pump ATPase C subunit isoforms (C2-a and C2-b) specifically expressed in kidney and lung. Sun-Wada GH, et al. J Biol Chem, 2003 Nov 7. PMID 12947086

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.
      Title: Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.
    2. Vacuolar-type proton ATPase is required for maintenance of apicobasal polarity of embryonic visceral endoderm.
      Title: Vacuolar-type proton ATPase is required for maintenance of apicobasal polarity of embryonic visceral endoderm.
    3. High glucose disrupts autophagy lysosomal pathway in gingival epithelial cells via ATP6V0C.
      Title: High glucose disrupts autophagy lysosomal pathway in gingival epithelial cells via ATP6V0C.
    4. Results show that inhibition of V-ATPase by archazolid reduces the activity of prometastatic proteases like cathepsin B in vitro and in vivo.
      Title: V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.
    5. mapped three ATP6V0C genes (Atp6v0c, Atp6v0c-ps1 and Atp6voc-ps2) in the murine genome
      Title: Chromosomal localization of three vacuolar-H+ -ATPase 16 kDa subunit (ATP6V0C) genes in the murine genome.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables P-type proton-exporting transporter activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lysosomal lumen acidification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of autophagic cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle lumen acidification EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in synaptic vesicle lumen acidification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle lumen acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vacuolar acidification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting V-type ATPase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting V-type ATPase, V0 domain TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of proton-transporting two-sector ATPase complex, proton-transporting domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transmembrane transporter complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of vacuolar proton-transporting V-type ATPase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    V-type proton ATPase 16 kDa proteolipid subunit c
    Names
    ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa
    ATPase, H+ transporting, lysosomal 16kD, V0 subunit C
    ATPase, H+ transporting, lysosomal 2
    H(+)-ATPase (mvp)
    V-ATPase 16 kDa proteolipid subunit
    V-ATPase 16 kDa proteolipid subunit c
    V-type proton ATPase 16 kDa proteolipid subunit
    vacuolar proton pump 16 kDa proteolipid subunit
    vacuolar proton pump 16 kDa proteolipid subunit c
    NP_001348460.1
    NP_001348461.1
    NP_001348462.1
    NP_001348463.1
    NP_001348464.1
    NP_033859.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361531.1 → NP_001348460.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BP769833, BY140472, CT010502
      Conserved Domains (2) summary
      TIGR01100
      Location:72 → 177
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      pfam00137
      Location:152 → 211
      ATP-synt_C; ATP synthase subunit C

    2. NM_001361532.1 → NP_001348461.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      CT010502
      Consensus CDS
      CCDS28476.1
      UniProtKB/Swiss-Prot
      P23967, P63082, Q3TD69
      UniProtKB/TrEMBL
      A3KML5, Q3UK60, Q4KL27, Q5XK06, Q8C1D9
      Related
      ENSMUSP00000111059.2, ENSMUST00000098862.9
      Conserved Domains (2) summary
      TIGR01100
      Location:13 → 118
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      cd18176
      Location:86 → 153
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins

    3. NM_001361533.1 → NP_001348462.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4-6 all encode the same isoform (c).
      Source sequence(s)
      BY140472, CT010502
      UniProtKB/TrEMBL
      Q3UK60
      Conserved Domains (2) summary
      cd18176
      Location:59 → 126
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
      cl00466
      Location:1 → 91
      ATP-synt_C; ATP synthase subunit C

    4. NM_001361534.1 → NP_001348463.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4-6 all encode the same isoform (c).
      Source sequence(s)
      CT010502
      UniProtKB/TrEMBL
      Q3UK60
      Conserved Domains (2) summary
      cd18176
      Location:59 → 126
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
      cl00466
      Location:1 → 91
      ATP-synt_C; ATP synthase subunit C

    5. NM_001361535.1 → NP_001348464.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4-6 all encode the same isoform (c).
      Source sequence(s)
      BB873227, CT010502
      UniProtKB/TrEMBL
      Q3UK60
      Conserved Domains (2) summary
      cd18176
      Location:59 → 126
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
      cl00466
      Location:1 → 91
      ATP-synt_C; ATP synthase subunit C

    6. NM_009729.4 → NP_033859.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform b

      See identical proteins and their annotated locations for NP_033859.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AK002570, BC050939, BY245103
      Consensus CDS
      CCDS28476.1
      UniProtKB/Swiss-Prot
      P23967, P63082, Q3TD69
      UniProtKB/TrEMBL
      A3KML5, Q3UK60, Q4KL27, Q5XK06, Q8C1D9
      Related
      ENSMUSP00000024932.6, ENSMUST00000024932.12
      Conserved Domains (2) summary
      TIGR01100
      Location:13 → 118
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      cd18176
      Location:86 → 153
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24382839..24388652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63082.1 GenPept UniProtKB/Swiss-Prot:P63082

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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