Pcolce2 procollagen C-endopeptidase enhancer 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcolce2provided by MGI
Official Full Name: procollagen C-endopeptidase enhancer 2provided by MGI
Primary source: MGI:MGI:1923727
See related: Ensembl:ENSMUSG00000015354 AllianceGenome:MGI:1923727
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pcpe2; 2400001O18Rik
Summary: Predicted to enable collagen binding activity; heparin binding activity; and peptidase activator activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in collagen-containing extracellular matrix. Is expressed in several structures, including branchial arch; jaw; limb; nasal cavity epithelium; and skeleton. Orthologous to human PCOLCE2 (procollagen C-endopeptidase enhancer 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 28.4), liver E18 (RPKM 4.2) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.3; 9 50.18 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (95519681..95577604)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (95637628..95695551)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.
Title: Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.
PCPE2 was shown to enhance SR-BI function by increasing the rate of HDL-associated cholesteryl ester uptake, possibly by optimizing SR-BI localization and/or conformation.
Title: Procollagen C-endopeptidase Enhancer Protein 2 (PCPE2) Reduces Atherosclerosis in Mice by Enhancing Scavenger Receptor Class B1 (SR-BI)-mediated High-density Lipoprotein (HDL)-Cholesteryl Ester Uptake.
It was shown that PCOLCE2 is required for efficient procollagen processing and deposition of fibrillar collagen in the pressure-overloaded myocardium.
Title: Effects of the absence of procollagen C-endopeptidase enhancer-2 on myocardial collagen accumulation in chronic pressure overload.
the role of the PCPE2 protein in an in vivo model
Title: Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels.
Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer protein 2, to chromosome 9.
Title: Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer protein 2, to chromosome 9 and localization of PCOLCE2 to human chromosome 3q23.
PCPE2 is shown to be a glycoprotein that differs markedly in the nature of its glycosylation from that of PCPE1
Title: PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Pcolce2 (e-PCR), detects polymorphism
- UniSTS:498436

Pcolce2 (e-PCR), detects polymorphism
- UniSTS:239204

D9Mit76 (e-PCR), detects polymorphism
- UniSTS:131963

Pcolce2 (e-PCR), detects polymorphism
- UniSTS:498347

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding	ISO Inferred from Sequence Orthology more info	PubMed
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables heparin binding	ISO Inferred from Sequence Orthology more info	PubMed
enables peptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activator activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: procollagen C-endopeptidase enhancer 2

Names: PCPE-2; procollagen C-proteinase enhancer 2; procollagen COOH-terminal proteinase enhancer 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029620.2 → NP_083896.1 procollagen C-endopeptidase enhancer 2 precursor

See identical proteins and their annotated locations for NP_083896.1

Status: VALIDATED

Source sequence(s)

AK010249, AK132395

Consensus CDS

CCDS23410.1

UniProtKB/Swiss-Prot

Q3V1K6, Q8R4W6, Q9CX06

Related

ENSMUSP00000015498.9, ENSMUST00000015498.9

Conserved Domains (3) summary

cd00041
Location:32 → 142

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd03576
Location:291 → 414

NTR_PCOLCE; NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which ...

pfam00431
Location:153 → 264

CUB; CUB domain