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    Nudt10 nudix hydrolase 10 [ Mus musculus (house mouse) ]

    Gene ID: 102954, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Nudt10provided by MGI
    Official Full Name
    nudix hydrolase 10provided by MGI
    Primary source
    MGI:MGI:2147931
    See related
    Ensembl:ENSMUSG00000073293 AllianceGenome:MGI:2147931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dipp3a; Dipp3b; Nudt11; DIPP3-beta
    Summary
    Enables diphosphoinositol-polyphosphate diphosphatase activity. Predicted to be involved in diphosphoinositol polyphosphate metabolic process and nucleotide catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human NUDT10 (nudix hydrolase 10) and NUDT11 (nudix hydrolase 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 15.5), whole brain E14.5 (RPKM 14.0) and 11 other tissues See more
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    Genomic context

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    See Nudt10 in Genome Data Viewer
    Location:
    X A1.1; X 2.74 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (6080750..6085321, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (6168696..6173009, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 26618 Neighboring gene EZH inhibitory protein Neighboring gene nuclear encoded rRNA 5S 2 Neighboring gene STARR-seq mESC enhancer starr_46654 Neighboring gene predicted gene, 33733 Neighboring gene predicted gene, 46685

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases. Hua LV, et al. Biochem J, 2003 Jul 1. PMID 12689335, Free PMC Article
    2. CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†. Lu Y, et al. Biol Reprod, 2019 Aug 1. PMID 31201419, Free PMC Article
    3. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High levels are expressed in liver, kidney and testis
      Title: Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bis(5'-adenosyl)-hexaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bis(5'-adenosyl)-pentaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diphosphoinositol-polyphosphate diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diphosphoinositol-polyphosphate diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diadenosine hexaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diadenosine pentaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diphosphoinositol polyphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    diphosphoinositol polyphosphate phosphohydrolase 3-alpha
    Names
    DIPP-3-alpha
    DIPP-3-beta
    DIPP3-alpha
    Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta
    Diphosphoinositol polyphosphate phosphohydrolase 3-beta
    Nucleoside diphosphate-linked moiety X motif 11
    Nudix motif 11
    diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha
    diadenosine hexaphosphate hydrolase (AMP-forming)
    nucleoside diphosphate-linked moiety X motif 10
    nudix (nucleoside diphosphate linked moiety X)-type motif 10
    nudix motif 10
    NP_001026834.1
    XP_006527609.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031664.1 → NP_001026834.1  diphosphoinositol polyphosphate phosphohydrolase 3-alpha

      See identical proteins and their annotated locations for NP_001026834.1

      Status: VALIDATED

      Source sequence(s)
      BC055771, CX209897
      Consensus CDS
      CCDS29957.1
      UniProtKB/Swiss-Prot
      P0C027, P0C028, Q8BKF4, Q9JJD3
      Related
      ENSMUSP00000100071.4, ENSMUST00000103006.4
      Conserved Domains (1) summary
      cd04666
      Location:18 → 137
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      6080750..6085321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527546.4 → XP_006527609.1  diphosphoinositol polyphosphate phosphohydrolase 3-alpha isoform X1

      See identical proteins and their annotated locations for XP_006527609.1

      UniProtKB/Swiss-Prot
      P0C027, P0C028, Q8BKF4, Q9JJD3
      Conserved Domains (1) summary
      cd04666
      Location:18 → 137
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C027.1 GenPept UniProtKB/Swiss-Prot:P0C027

    Gene LinkOut

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