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    ZDHHC21 zinc finger DHHC-type palmitoyltransferase 21 [ Homo sapiens (human) ]

    Gene ID: 340481, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZDHHC21provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 21provided by HGNC
    Primary source
    HGNC:HGNC:20750
    See related
    Ensembl:ENSG00000175893 MIM:614605; AllianceGenome:HGNC:20750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DNZ1; DHHC21; DHHC-21; HSPC097
    Summary
    Enables palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 3.1), skin (RPKM 2.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    9p22.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (14588797..14693432, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (14598473..14703138, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (14611069..14693430, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene nuclear factor I B Neighboring gene uncharacterized LOC124902121 Neighboring gene uncharacterized LOC124902120 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:14547038-14547640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:14597299-14597830 Neighboring gene cell division cycle associated 4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19776 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:14693435-14693935 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:14721879-14722818 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:14722819-14723756 Neighboring gene uncharacterized LOC105375979 Neighboring gene cerberus 1, DAN family BMP antagonist Neighboring gene FRAS1 related extracellular matrix 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics. Marin EP, et al. Arterioscler Thromb Vasc Biol, 2016 Feb. PMID 26715683, Free PMC Article
    2. Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome. Beard RS Jr, et al. Nat Commun, 2016 Sep 22. PMID 27653213, Free PMC Article
    3. Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases. Marin EP, et al. Circ Res, 2012 May 11. PMID 22496122, Free PMC Article
    4. Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03). Le Clerc S, et al. J Infect Dis, 2009 Oct 15. PMID 19754311
    5. DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. Pedram A, et al. Mol Biol Cell, 2012 Jan. PMID 22031296, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The palmitoyltransferase ZDHHC21 regulates oxidative phosphorylation to induce differentiation block and stemness in AML.
      Title: The palmitoyltransferase ZDHHC21 regulates oxidative phosphorylation to induce differentiation block and stemness in AML.
    2. We show that knockdown of ZDHHC21 leads to reduced levels of platelet endothelial cell adhesion molecule-1 at the cell surface.
      Title: Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.
    3. the DHHC-7 and -21 proteins are novel targets to selectively inhibit membrane sex steroid receptor localization and function
      Title: DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Novel associations for hypothyroidism include known autoimmune risk loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 9130404H11Rik

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in adrenergic receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in hair follicle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitric oxide metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-L-cysteine S-palmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of establishment of endothelial barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of leukocyte adhesion to arterial endothelial cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of vascular associated smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sebaceous gland development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC21
    Names
    DHHC domain-containing cysteine-rich protein 21
    zinc finger DHHC-type containing 21
    zinc finger, DHHC domain containing 21
    NP_001341047.1
    NP_001341048.1
    NP_001341049.1
    NP_001341050.1
    NP_001341051.1
    NP_001341052.1
    NP_001341053.1
    NP_001341054.1
    NP_001341055.1
    NP_001341056.1
    NP_001341057.1
    NP_001341058.1
    NP_001341059.1
    NP_848661.1
    XP_016870172.1
    XP_047279289.1
    XP_047279290.1
    XP_054218875.1
    XP_054218876.1
    XP_054218877.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001354118.2 → NP_001341047.1  palmitoyltransferase ZDHHC21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    2. NM_001354119.2 → NP_001341048.1  palmitoyltransferase ZDHHC21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    3. NM_001354120.2 → NP_001341049.1  palmitoyltransferase ZDHHC21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    4. NM_001354121.2 → NP_001341050.1  palmitoyltransferase ZDHHC21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    5. NM_001354122.2 → NP_001341051.1  palmitoyltransferase ZDHHC21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    6. NM_001354123.2 → NP_001341052.1  palmitoyltransferase ZDHHC21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    7. NM_001354124.2 → NP_001341053.1  palmitoyltransferase ZDHHC21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    8. NM_001354125.2 → NP_001341054.1  palmitoyltransferase ZDHHC21 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Conserved Domains (1) summary
      pfam01529
      Location:63 → 188
      zf-DHHC; DHHC palmitoyltransferase

    9. NM_001354126.2 → NP_001341055.1  palmitoyltransferase ZDHHC21 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Conserved Domains (1) summary
      pfam01529
      Location:63 → 188
      zf-DHHC; DHHC palmitoyltransferase

    10. NM_001354127.2 → NP_001341056.1  palmitoyltransferase ZDHHC21 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Conserved Domains (1) summary
      pfam01529
      Location:2 → 120
      DHHC; DHHC palmitoyltransferase

    11. NM_001354128.2 → NP_001341057.1  palmitoyltransferase ZDHHC21 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Conserved Domains (1) summary
      pfam01529
      Location:2 → 120
      DHHC; DHHC palmitoyltransferase

    12. NM_001354129.2 → NP_001341058.1  palmitoyltransferase ZDHHC21 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Conserved Domains (1) summary
      pfam01529
      Location:2 → 120
      DHHC; DHHC palmitoyltransferase

    13. NM_001354130.2 → NP_001341059.1  palmitoyltransferase ZDHHC21 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Conserved Domains (1) summary
      pfam01529
      Location:2 → 120
      DHHC; DHHC palmitoyltransferase

    14. NM_178566.6 → NP_848661.1  palmitoyltransferase ZDHHC21 isoform 1

      See identical proteins and their annotated locations for NP_848661.1

      Status: VALIDATED

      Source sequence(s)
      AK292960, AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Related
      ENSP00000370303.3, ENST00000380916.9
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    RNA

    1. NR_148714.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390732

    2. NR_148715.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390732

    3. NR_148716.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390732

    4. NR_148717.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390732

    5. NR_148718.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390732

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      14588797..14693432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014683.2 → XP_016870172.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92 → 217
      DHHC; DHHC palmitoyltransferase

    2. XM_047423334.1 → XP_047279290.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6

    3. XM_047423333.1 → XP_047279289.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6

    RNA

    1. XR_001746284.2 RNA Sequence

    2. XR_001746285.2 RNA Sequence

    3. XR_007061286.1 RNA Sequence

    4. XR_007061285.1 RNA Sequence

    5. XR_007061287.1 RNA Sequence

    6. XR_007061288.1 RNA Sequence

    7. XR_002956779.2 RNA Sequence

    8. XR_007061290.1 RNA Sequence

    9. XR_007061289.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      14598473..14703138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362900.1 → XP_054218875.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6

    2. XM_054362902.1 → XP_054218877.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6

    3. XM_054362901.1 → XP_054218876.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6

    RNA

    1. XR_008488005.1 RNA Sequence

    2. XR_008488004.1 RNA Sequence

    3. XR_008488001.1 RNA Sequence

    4. XR_008488003.1 RNA Sequence

    5. XR_008488002.1 RNA Sequence

    6. XR_008488007.1 RNA Sequence

    7. XR_008488006.1 RNA Sequence

    8. XR_008488008.1 RNA Sequence

    9. XR_008488009.1 RNA Sequence

    10. XR_008488011.1 RNA Sequence

    11. XR_008488010.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IVQ6.1 GenPept UniProtKB/Swiss-Prot:Q8IVQ6

    Gene LinkOut

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