Chn1 chimerin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chn1provided by MGI
Official Full Name: chimerin 1provided by MGI
Primary source: MGI:MGI:1915674
See related: Ensembl:ENSMUSG00000056486 AllianceGenome:MGI:1915674
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARHGAP2; 0610007I19Rik; 0710001E19Rik; 1700112L09Rik; 2900046J01Rik
Summary: Enables ephrin receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; motor neuron axon guidance; and regulation of GTPase activity. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Used to study Duane retraction syndrome. Human ortholog(s) of this gene implicated in Duane retraction syndrome. Orthologous to human CHN1 (chimerin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 122.5), frontal lobe adult (RPKM 81.5) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C3; 2 43.78 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (73441004..73605723, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (73610660..73775367, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rac1 activation and expression of alpha2-chimaerin are stimulated by single-trial contextual fear conditioning. The balance between activated Rac1 and expressed alpha2-chimaerin defines dynamic long-term memory maintenance.
Title: Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory.
These findings reveal a role for ephrin bidirectional signaling upstream of mutant alpha2-chimaerin in Duane retraction syndrome, which may contribute to the selective vulnerability of abducens motor neurons in this disorder
Title: Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome.
This study showed that, in the mouse, hippocampal alpha2-chimaerin acts in the late postnatal stages (juvenile and adolescence) to establish both the baseline level of the dendritic spine morphology and normal contextual fear-learning ability in adulthood
Title: Developmental RacGAP α2-Chimaerin Signaling Is a Determinant of the Morphological Features of Dendritic Spines in Adulthood.
Developmental alpha2-chimaerin activity is important for adult cognition.
Title: RacGAP α2-chimaerin function in development adjusts cognitive ability in adulthood.
Chimaerins are RhoGTPase-activating proteins that are EphA4 effectors and have been implicated in a number of processes including growth cone collapse, axon guidance, dendritic spine development and the formation of corticospinal motor circuits.
Title: Identification of α-chimaerin as a candidate gene for critical period neuronal plasticity in cat and mouse visual cortex.
These findings establish a new alpha2-chimaerin-dependent mechanism underlying neuronal migration and proper functioning of the cerebral cortex and provide insights into the pathogenesis of seizure-related neurodevelopmental disorders.
Title: α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2.
These findings identify alpha2-chimaerin as an indispensable effector for EphA4 in cortical and spinal motor circuits.
Title: alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits.
Our results reveal an alpha-chimaerin-dependent signaling pathway downstream of EphA4, which is essential for axon guidance decisions and neuronal circuit formation in vivo.
Title: EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin.
Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of Efnb3 forward signaling
Title: Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling.
lpha1-chimaerin is an activity-regulated Rho GTPase regulator that is activated by phospholipase Cbeta-coupled cell surface receptors and contributes to pruning of dendritic arbors
Title: The diacylglycerol-binding protein alpha1-chimaerin regulates dendritic morphology.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1) 1 citation
Spontaneous (1) 1 citation
Targeted (13) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ephrin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-chimaerin

Names: A-chimaerin; N-chimerin; NC; alpha-chimerin; alpha1 chimaerin; alpha2 chimaerin; alpha3-chimerin; chimaerin; chimerin (chimaerin) 1; rho GTPase-activating protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113246.2 → NP_001106717.2 N-chimaerin isoform 3

See identical proteins and their annotated locations for NP_001106717.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longest isoform (3).

Source sequence(s)

AK019340, AK032630, AK147686, BC054770, BY638589, CA749754

Consensus CDS

CCDS50608.1

UniProtKB/Swiss-Prot

A2ATM0, Q3UGY3, Q7TQE5, Q8BWU6, Q91V57, Q9D9B3

Related

ENSMUSP00000107655.4, ENSMUST00000112024.10

Conserved Domains (3) summary

cd10352
Location:42 → 128

SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins

cd04372
Location:266 → 459

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

pfam00130
Location:206 → 255

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001166603.1 → NP_001160075.1 N-chimaerin isoform 4

See identical proteins and their annotated locations for NP_001160075.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an in-frame coding exon, as compared to variant 3. The resulting isoform (4) lacks an internal segment, as compared to isoform 3.

Source sequence(s)

AB264772, AK019340, AK032630, BY638589, CA749754

Consensus CDS

CCDS50607.1

UniProtKB/TrEMBL

A7VK13

Related

ENSMUSP00000128847.2, ENSMUST00000166199.9

Conserved Domains (3) summary

cd10352
Location:42 → 128

SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins

pfam00130
Location:206 → 237

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl02570
Location:234 → 401

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_001166604.1 → NP_001160076.1 N-chimaerin isoform 5

See identical proteins and their annotated locations for NP_001160076.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks multiple 5' exons and an in-frame exon in the coding region, as compared to variant 3. The resulting isoform (5) is shorter, has a distinct N-terminus and lacks an internal segment, as compared to isoform 3.

Source sequence(s)

AB264771, AK019340, AK032630, BY239371, BY638589

UniProtKB/TrEMBL

A7VK12

Conserved Domains (2) summary

pfam00130
Location:81 → 112

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl02570
Location:109 → 276

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_029716.3 → NP_083992.1 N-chimaerin isoform 2

See identical proteins and their annotated locations for NP_083992.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks multiple 5' exons but has an alternate 5' exon, as compared to variant 3. The translation initiates at the downstream AUG codon and the resulting isoform (2) has a much shorter N-terminus, as compared to isoform 3.

Source sequence(s)

AK007182, AK019340, AK032630, BY638589

Consensus CDS

CCDS38145.1

UniProtKB/TrEMBL

A7VK14

Related

ENSMUSP00000070301.7, ENSMUST00000070579.7

Conserved Domains (1) summary

cd04372
Location:17 → 210

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
NM_175752.3 → NP_786928.2 N-chimaerin isoform 1

See identical proteins and their annotated locations for NP_786928.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks multiple 5' exons and has an alternate 5' segment, as compared to variant 3. The resulting isoform (1) is shorter and has a distinct N-terminus, as compared to isoform 3.

Source sequence(s)

AK019340, AK032630, AK049943, BY239371, BY638589

Consensus CDS

CCDS16133.1

UniProtKB/Swiss-Prot

Q91V57

Related

ENSMUSP00000099738.5, ENSMUST00000102677.11

Conserved Domains (2) summary

cd04372
Location:141 → 334

RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...

pfam00130
Location:81 → 133

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

73441004..73605723 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246554.2 → XP_030102414.1 N-chimaerin isoform X5

Conserved Domains (2) summary

cd04372
Location:41 → 234

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cl00040
Location:1 → 32

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_006498561.4 → XP_006498624.1 N-chimaerin isoform X5

Conserved Domains (2) summary

cd04372
Location:41 → 234

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cl00040
Location:1 → 32

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_006498557.3 → XP_006498620.2 N-chimaerin isoform X1

Conserved Domains (3) summary

cd10352
Location:150 → 236

SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins

cd04372
Location:348 → 541

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

pfam00130
Location:291 → 337

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_036157414.1 → XP_036013307.1 N-chimaerin isoform X5

Conserved Domains (2) summary

cd04372
Location:41 → 234

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cl00040
Location:1 → 32

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_036157409.1 → XP_036013302.1 N-chimaerin isoform X5

Conserved Domains (2) summary

cd04372
Location:41 → 234

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cl00040
Location:1 → 32

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_006498558.2 → XP_006498621.2 N-chimaerin isoform X2

Conserved Domains (3) summary

cd04372
Location:336 → 529

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

pfam00130
Location:276 → 325

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl15255
Location:158 → 198

SH2; Src homology 2 (SH2) domain
XM_030246546.1 → XP_030102406.1 N-chimaerin isoform X5

Conserved Domains (2) summary

cd04372
Location:41 → 234

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cl00040
Location:1 → 32

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_030246537.1 → XP_030102397.1 N-chimaerin isoform X5

Conserved Domains (2) summary

cd04372
Location:41 → 234

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cl00040
Location:1 → 32

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_030246534.2 → XP_030102394.1 N-chimaerin isoform X3

Conserved Domains (3) summary

cd04372
Location:214 → 407

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

pfam00130
Location:154 → 203

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl15255
Location:1 → 76

SH2; Src homology 2 (SH2) domain
XM_030246543.1 → XP_030102403.1 N-chimaerin isoform X5

Conserved Domains (2) summary

cd04372
Location:41 → 234

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cl00040
Location:1 → 32

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_030246532.1 → XP_030102392.1 N-chimaerin isoform X3

Conserved Domains (3) summary

cd04372
Location:214 → 407

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

pfam00130
Location:154 → 203

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl15255
Location:1 → 76

SH2; Src homology 2 (SH2) domain
XM_036157423.1 → XP_036013316.1 N-chimaerin isoform X5

Conserved Domains (2) summary

cd04372
Location:41 → 234

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cl00040
Location:1 → 32

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_006498560.4 → XP_006498623.1 N-chimaerin isoform X4

Conserved Domains (2) summary

cd04372
Location:93 → 286

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

pfam00130
Location:33 → 82

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)