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    Nfil3 nuclear factor, interleukin 3, regulated [ Mus musculus (house mouse) ]

    Gene ID: 18030, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Nfil3provided by MGI
    Official Full Name
    nuclear factor, interleukin 3, regulatedprovided by MGI
    Primary source
    MGI:MGI:109495
    See related
    Ensembl:ENSMUSG00000056749 AllianceGenome:MGI:109495
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E4BP4
    Summary
    The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses Per1 and Per2 expression and therefore plays a role in the regulation of circadian rhythm. [provided by RefSeq, Feb 2014]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 2.7), CNS E14 (RPKM 2.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nfil3 in Genome Data Viewer
    Location:
    13 B1; 13 27.68 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (53121245..53136914, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (52967209..52982878, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33315 Neighboring gene AU RNA binding protein/enoyl-coenzyme A hydratase Neighboring gene STARR-seq mESC enhancer starr_34553 Neighboring gene STARR-positive B cell enhancer ABC_E3081 Neighboring gene STARR-positive B cell enhancer mm9_chr13:53024873-53025174 Neighboring gene STARR-seq mESC enhancer starr_34554 Neighboring gene STARR-positive B cell enhancer ABC_E4070 Neighboring gene predicted gene, 40950 Neighboring gene STARR-seq mESC enhancer starr_34555 Neighboring gene predicted gene, 33424 Neighboring gene predicted gene, 33519 Neighboring gene STARR-positive B cell enhancer mm9_chr13:53204966-53205267 Neighboring gene STARR-seq mESC enhancer starr_34558 Neighboring gene receptor tyrosine kinase-like orphan receptor 2 Neighboring gene predicted gene, 52058

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-Fat Diet-Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice. Wang S, et al. Diabetes, 2023 Mar 1. PMID 36508222, Free PMC Article
    2. NFIL3 deficiency alleviates EAE through regulating different immune cell subsets. Chen Z, et al. J Adv Res, 2022 Jul. PMID 35777910, Free PMC Article
    3. E4BP4 Regulates Hepatic Solute Carrier Family 2 Member 9 and Uric Acid Disposition in Mice. Wang Z, et al. Drug Metab Dispos, 2022 May. PMID 35246462
    4. Cutaneous Squamous Cell Carcinoma Development Is Associated with a Temporal Infiltration of ILC1 and NK Cells with Immune Dysfunctions. Luci C, et al. J Invest Dermatol, 2021 Oct. PMID 33831432
    5. Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet-induced ER stress. Yang M, et al. FASEB J, 2020 Oct. PMID 32780887, Free PMC Article

    See all (124) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The transcription factor NFIL3/E4BP4 regulates the developmental stage-specific acquisition of basophil function.
      Title: The transcription factor NFIL3/E4BP4 regulates the developmental stage-specific acquisition of basophil function.
    2. CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.
      Title: CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.
    3. High-Fat Diet-Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice.
      Title: High-Fat Diet-Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice.
    4. NFIL3 deficiency alleviates EAE through regulating different immune cell subsets.
      Title: NFIL3 deficiency alleviates EAE through regulating different immune cell subsets.
    5. E4BP4 Regulates Hepatic Solute Carrier Family 2 Member 9 and Uric Acid Disposition in Mice.
      Title: E4BP4 Regulates Hepatic Solute Carrier Family 2 Member 9 and Uric Acid Disposition in Mice.
    6. Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet-induced ER stress.
      Title: Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet-induced ER stress.
    7. E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
      Title: E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
    8. The ILC3s are attuned to circadian rhythm, but clock regulator REV-ERBalpha also has circadian-independent impacts on ILC3 development and functions due to its roles in the regulation of RORgammat.
      Title: Circadian rhythm-dependent and circadian rhythm-independent impacts of the molecular clock on type 3 innate lymphoid cells.
    9. The data indicate that NFIL3 impairs Regulatory T (Treg) cell function through the downregulation of Foxp3 expression.
      Title: The transcription factor NFIL3 controls regulatory T-cell function and stability.
    10. D-box-mediated transcriptional regulation plays pivotal roles in input and output in the circadian clock system.
      Title: Functional D-box sequences reset the circadian clock and drive mRNA rhythms.
    Submit: New GeneRIF Correction See all GeneRIFs (56)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to interleukin-4 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nuclear factor interleukin-3-regulated protein
    Names
    E4 promoter-binding protein 4
    embryo implantation-related NFIL3/E4BP4-like transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017373.3 → NP_059069.1  nuclear factor interleukin-3-regulated protein

      See identical proteins and their annotated locations for NP_059069.1

      Status: VALIDATED

      Source sequence(s)
      AK087541, BB872092, BC031377, BQ899715
      Consensus CDS
      CCDS26519.1
      UniProtKB/Swiss-Prot
      O08750, Q3ULK2, Q497U0
      Related
      ENSMUSP00000065363.8, ENSMUST00000071065.8
      Conserved Domains (2) summary
      cd14694
      Location:72 → 131
      bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
      pfam06529
      Location:130 → 461
      Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      53121245..53136914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516877.3 → XP_006516940.1  nuclear factor interleukin-3-regulated protein isoform X1

      See identical proteins and their annotated locations for XP_006516940.1

      UniProtKB/Swiss-Prot
      O08750, Q3ULK2, Q497U0
      Conserved Domains (2) summary
      cd14694
      Location:72 → 131
      bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
      pfam06529
      Location:130 → 461
      Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor

    2. XM_036157903.1 → XP_036013796.1  nuclear factor interleukin-3-regulated protein isoform X1

      UniProtKB/Swiss-Prot
      O08750, Q3ULK2, Q497U0
      Conserved Domains (2) summary
      cd14694
      Location:72 → 131
      bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
      pfam06529
      Location:130 → 461
      Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor

    3. XM_017315418.2 → XP_017170907.1  nuclear factor interleukin-3-regulated protein isoform X1

      UniProtKB/Swiss-Prot
      O08750, Q3ULK2, Q497U0
      Conserved Domains (2) summary
      cd14694
      Location:72 → 131
      bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
      pfam06529
      Location:130 → 461
      Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08750.1 GenPept UniProtKB/Swiss-Prot:O08750

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