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    Ctdp1 CTD phosphatase subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 67655, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Ctdp1provided by MGI
    Official Full Name
    CTD phosphatase subunit 1provided by MGI
    Primary source
    MGI:MGI:1926953
    See related
    Ensembl:ENSMUSG00000033323 AllianceGenome:MGI:1926953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930563P03Rik
    Summary
    Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity; TFIIF-class transcription factor complex binding activity; and Tat protein binding activity. Predicted to be involved in several processes, including dephosphorylation of RNA polymerase II C-terminal domain; negative regulation of cell growth involved in cardiac muscle cell development; and positive regulation by host of viral transcription. Predicted to act upstream of or within cell division. Predicted to be located in microtubule cytoskeleton; midbody; and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human CTDP1 (CTD phosphatase subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 3.7), ovary adult (RPKM 3.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 E3; 18 53.48 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (80451174..80522959, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (80407959..80478739, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily G, member 2 Neighboring gene RIKEN cDNA D330025C20 gene Neighboring gene predicted gene, 29967 Neighboring gene STARR-seq mESC enhancer starr_45177 Neighboring gene predicted gene 9456 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:80689226-80689427 Neighboring gene predicted gene, 30020 Neighboring gene predicted gene, 41788

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs. Qiao F, et al. Biol Open, 2021 Jan 6. PMID 33408128, Free PMC Article
    2. Human capping enzyme promotes formation of transcriptional R loops in vitro. Kaneko S, et al. Proc Natl Acad Sci U S A, 2007 Nov 6. PMID 17978174, Free PMC Article
    3. Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. Yamamoto K, et al. Mol Cell Biol, 2004 Jul. PMID 15226435, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs.
      Title: Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TFIIF-class transcription factor complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Tat protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exit from mitosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle midzone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase II subunit A C-terminal domain phosphatase
    Names
    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
    TFIIF-associating CTD phosphatase
    NP_080571.2
    XP_006526588.1
    XP_011245398.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026295.3 → NP_080571.2  RNA polymerase II subunit A C-terminal domain phosphatase

      See identical proteins and their annotated locations for NP_080571.2

      Status: VALIDATED

      Source sequence(s)
      BC053435, BY239926
      Consensus CDS
      CCDS29368.1
      UniProtKB/Swiss-Prot
      Q7TSG2, Q7TSS7, Q9D4S8
      UniProtKB/TrEMBL
      Q3U0S4
      Related
      ENSMUSP00000038938.7, ENSMUST00000036229.13
      Conserved Domains (4) summary
      TIGR02250
      Location:177 → 323
      FCP1_euk; FCP1-like phosphatase, phosphatase domain
      cd06850
      Location:27 → 111
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      cd00027
      Location:637 → 706
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam09309
      Location:706 → 960
      FCP1_C; FCP1, C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      80451174..80522959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526525.5 → XP_006526588.1  RNA polymerase II subunit A C-terminal domain phosphatase isoform X1

      UniProtKB/TrEMBL
      Q3U0S4
      Conserved Domains (4) summary
      TIGR02250
      Location:177 → 323
      FCP1_euk; FCP1-like phosphatase, phosphatase domain
      cd06850
      Location:27 → 111
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      cd17729
      Location:611 → 713
      BRCT_CTDP1; BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins
      pfam09309
      Location:706 → 799
      FCP1_C; FCP1, C-terminal

    2. XM_011247096.2 → XP_011245398.1  RNA polymerase II subunit A C-terminal domain phosphatase isoform X2

      See identical proteins and their annotated locations for XP_011245398.1

      UniProtKB/TrEMBL
      Q3U0S4
      Conserved Domains (3) summary
      TIGR02250
      Location:58 → 204
      FCP1_euk; FCP1-like phosphatase, phosphatase domain
      cd17729
      Location:492 → 594
      BRCT_CTDP1; BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins
      pfam09309
      Location:587 → 841
      FCP1_C; FCP1, C-terminal

    RNA

    1. XR_003952539.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSG2.1 GenPept UniProtKB/Swiss-Prot:Q7TSG2

    Gene LinkOut

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