Serpinb8 serine (or cysteine) peptidase inhibitor, clade B, member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpinb8provided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade B, member 8provided by MGI
Primary source: MGI:MGI:894657
See related: Ensembl:ENSMUSG00000026315 AllianceGenome:MGI:894657
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAP2; NK10; Spi8; CAP-2; ovalbumin
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in epithelial cell-cell adhesion and negative regulation of endopeptidase activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in peeling skin syndrome. Orthologous to human SERPINB8 (serpin family B member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in kidney adult (RPKM 2.4), bladder adult (RPKM 2.0) and 16 other tissues See more
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Genomic context

Location:: 1 E2.1; 1 50.34 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (107517668..107536708)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (107589926..107608978)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE311274 (e-PCR)
- UniSTS:207197

D1Mit388 (e-PCR), detects polymorphism
- UniSTS:128749

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in epithelial cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serpin B8

Names: serine (or cysteine) peptdiase inhibitor, clade B, member 8; serine (or cysteine) proteinase inhibitor, clade B, member 8; serine protease inhibitor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159748.1 → NP_001153220.1 serpin B8 isoform 2

See identical proteins and their annotated locations for NP_001153220.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK032659, AK048230

UniProtKB/TrEMBL

Q8C871

Related

ENSMUST00000151283.2

Conserved Domains (1) summary

cl38926
Location:1 → 241

serpin; SERine Proteinase INhibitors (serpin) family
NM_011459.4 → NP_035589.1 serpin B8 isoform 1

See identical proteins and their annotated locations for NP_035589.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC015658, AK032659, AK036811

Consensus CDS

CCDS15220.1

UniProtKB/Swiss-Prot

O08800

UniProtKB/TrEMBL

Q3UFM1

Related

ENSMUSP00000108326.3, ENSMUST00000112706.4

Conserved Domains (1) summary

cl00137
Location:4 → 374

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...