Ttyh3 tweety family member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ttyh3provided by MGI
Official Full Name: tweety family member 3provided by MGI
Primary source: MGI:MGI:1925589
See related: Ensembl:ENSMUSG00000036565 AllianceGenome:MGI:1925589
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TTY3; mTTY3; 2900029G13Rik
Summary: Predicted to enable intracellular calcium activated chloride channel activity and volume-sensitive chloride channel activity. Predicted to be involved in chloride transport. Predicted to act upstream of or within ion transport. Predicted to be integral component of membrane. Predicted to be part of chloride channel complex. Predicted to be active in plasma membrane. Is expressed in retina. Orthologous to human TTYH3 (tweety family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 79.8), whole brain E14.5 (RPKM 56.1) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 79.16 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (140606332..140634826, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (140620577..140649071, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca(2+)-dependent switch from intra- to intermembrane dimerization.
Title: Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca(2+)-dependent switch from intra- to intermembrane dimerization.
This study demonistrated that Ttyh3 gene expression in mouse dorsal raphe nucleus
Title: Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Down-regulation of mTTYH3 may point towards its involvement in complex cystic fibrosis pathology. However, markedly reduced expression argues against direct compensatory action as alternative anion conductance.
Title: Quantitative expression analyses of candidates for alternative anion conductance in cystic fibrosis mouse models.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly calcium-gated chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly calcium-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables volume-sensitive chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables volume-sensitive chloride channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-glutamate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein tweety homolog 3

Names: tweety homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308040.1 → NP_001294969.1 protein tweety homolog 3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region, resulting in a frameshift, compared to variant 2. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 2.

Source sequence(s)

AI843734, BC059083, BC062917

Consensus CDS

CCDS80450.1

UniProtKB/Swiss-Prot

Q6P5F7

Related

ENSMUSP00000142655.2, ENSMUST00000197452.5

Conserved Domains (1) summary

pfam04906
Location:25 → 430

Tweety; Tweety
NM_175274.5 → NP_780483.2 protein tweety homolog 3 isoform 2

See identical proteins and their annotated locations for NP_780483.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).

Source sequence(s)

AI843734, BC062917

Consensus CDS

CCDS19822.1

UniProtKB/Swiss-Prot

Q69ZD3, Q6P5F7, Q6PCX0, Q8C789

Related

ENSMUSP00000037447.4, ENSMUST00000042661.8

Conserved Domains (1) summary

pfam04906
Location:25 → 430

Tweety; Tweety

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

140606332..140634826 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321177.2 → XP_017176666.1 protein tweety homolog 3 isoform X3

Conserved Domains (1) summary

pfam04906
Location:25 → 430

Tweety
XM_030254906.2 → XP_030110766.1 protein tweety homolog 3 isoform X2

Conserved Domains (1) summary

pfam04906
Location:80 → 447

Tweety
XM_030254907.2 → XP_030110767.1 protein tweety homolog 3 isoform X4

Conserved Domains (1) summary

pfam04906
Location:80 → 447

Tweety
XM_030254905.2 → XP_030110765.1 protein tweety homolog 3 isoform X1

Conserved Domains (1) summary

pfam04906
Location:80 → 447

Tweety

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001308039.1: Suppressed sequence

Description

NM_001308039.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.