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    Gimap1 GTPase, IMAP family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 16205, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Gimap1provided by MGI
    Official Full Name
    GTPase, IMAP family member 1provided by MGI
    Primary source
    MGI:MGI:109368
    See related
    Ensembl:ENSMUSG00000090019 AllianceGenome:MGI:109368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    imap; IAP38; Imap38
    Summary
    This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. Sequence analysis identified two alternatively spliced variants that encode the same protein. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in spleen adult (RPKM 37.2), thymus adult (RPKM 24.9) and 11 other tissues See more
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    Genomic context

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    See Gimap1 in Genome Data Viewer
    Location:
    6 B2.3; 6 23.69 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48715981..48720729)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48739047..48743795)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene GTPase, IMAP family member 6 Neighboring gene STARR-positive B cell enhancer ABC_E8100 Neighboring gene STARR-positive B cell enhancer ABC_E6427 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:48668564-48668753 Neighboring gene GTPase, IMAP family member 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:48677906-48678089 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:48682931-48683193 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:48688984-48689167 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:48689235-48689400 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:48696005-48696158 Neighboring gene STARR-positive B cell enhancer ABC_E10378 Neighboring gene STARR-positive B cell enhancer ABC_E1320 Neighboring gene GTPase, IMAP family member 5 Neighboring gene STARR-seq mESC enhancer starr_15794 Neighboring gene STARR-positive B cell enhancer ABC_E8101 Neighboring gene GTPase, IMAP family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria. Saunders A, et al. Malar J, 2009 Apr 2. PMID 19338674, Free PMC Article
    2. Spleen-specific expression of the malaria-inducible intronless mouse gene imap38. Krücken J, et al. J Biol Chem, 1999 Aug 20. PMID 10446218
    3. Novel gene expressed in spleen cells mediating acquired testosterone-resistant immunity to Plasmodium chabaudi malaria. Krücken J, et al. Biochem Biophys Res Commun, 1997 Jan 3. PMID 9020038
    4. Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice. Datta P, et al. Eur J Immunol, 2017 Jan. PMID 27792288, Free PMC Article
    5. GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo. Webb LM, et al. J Immunol, 2016 Jan 1. PMID 26621859, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study shows that GIMAP1 is critical for maintaining the peripheral T-cell pool in mice and offers a potent target for the treatment of T-cell-mediated diseases.
      Title: Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice.
    2. The data suggest that GIMAP1 is absolutely essential for the survival of peripheral B cells, irrespective of their activation state.
      Title: GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo.
    3. These findings show a vital requirement for GIMAP1 in mature lymphocyte development/survival
      Title: Putative GTPase GIMAP1 is critical for the development of mature B and T lymphocytes.
    4. The model of up-regulation of GIMAP1 in response to infection/immunization with P. chabaudi is not a robustly reproducible experimental system.
      Title: Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Chemically induced (ENU) (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within CD4-positive, alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within CD8-positive, alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase IMAP family member 1
    Names
    immune associated nucleotide family member
    immune-associated protein 38
    immunity-associated protein 1
    immunity-associated protein, 38 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008376.3 → NP_032402.2  GTPase IMAP family member 1

      See identical proteins and their annotated locations for NP_032402.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer and predominant variant. Both variants encode the same protein.
      Source sequence(s)
      CAAA01157263
      Consensus CDS
      CCDS20113.1
      UniProtKB/Swiss-Prot
      P70224
      UniProtKB/TrEMBL
      Q3TFI6
      Related
      ENSMUSP00000062108.5, ENSMUST00000054368.7
      Conserved Domains (2) summary
      cd01852
      Location:27 → 229
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)
      cl00459
      Location:217 → 294
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    2. NM_175860.2 → NP_787056.1  GTPase IMAP family member 1

      See identical proteins and their annotated locations for NP_787056.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1, that results in a shorter transcript. Both variants encode the same protein.
      Source sequence(s)
      CAAA01157263
      Consensus CDS
      CCDS20113.1
      UniProtKB/Swiss-Prot
      P70224
      UniProtKB/TrEMBL
      Q3TFI6
      Related
      ENSMUSP00000145479.2, ENSMUST00000204168.2
      Conserved Domains (2) summary
      cd01852
      Location:27 → 229
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)
      cl00459
      Location:217 → 294
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      48715981..48720729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70224.3 GenPept UniProtKB/Swiss-Prot:P70224

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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