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    Cpa4 carboxypeptidase A4 [ Mus musculus (house mouse) ]

    Gene ID: 71791, updated on 12-May-2024

    Summary

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    Official Symbol
    Cpa4provided by MGI
    Official Full Name
    carboxypeptidase A4provided by MGI
    Primary source
    MGI:MGI:1919041
    See related
    Ensembl:ENSMUSG00000039070 AllianceGenome:MGI:1919041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110019K20Rik
    Summary
    This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases that could be involved in the histone hyperacetylation pathway. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in stomach adult (RPKM 3.3), limb E14.5 (RPKM 1.8) and 6 other tissues See more
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    Genomic context

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    See Cpa4 in Genome Data Viewer
    Location:
    6 A3.3; 6 12.52 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30568368..30592417)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30568369..30592418)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15468 Neighboring gene serine-rich single-pass membrane protein 1 Neighboring gene predicted gene, 53278 Neighboring gene carboxypeptidase A2, pancreatic Neighboring gene predicted gene, 31453 Neighboring gene carboxypeptidase A5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing. Tanco S, et al. J Biol Chem, 2010 Jun 11. PMID 20385563, Free PMC Article
    2. Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling. Gao W, et al. Biosci Rep, 2020 May 29. PMID 32347291, Free PMC Article
    3. Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Hald J, et al. Dev Biol, 2003 Aug 15. PMID 12921743
    4. Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Inagawa M, et al. Mech Dev, 2013 Nov-Dec. PMID 23892084
    5. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling.
      Title: Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling.
    2. CPA4 functions in neuropeptide processing and regulation in the extracellular environment
      Title: Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in hormone catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase A4
    NP_082202.1
    XP_017177239.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027926.3 → NP_082202.1  carboxypeptidase A4 preproprotein

      See identical proteins and their annotated locations for NP_082202.1

      Status: REVIEWED

      Source sequence(s)
      AC155656, AK003823, AK030705
      Consensus CDS
      CCDS19975.1
      UniProtKB/Swiss-Prot
      Q6P8K8, Q8BMK6, Q9CTE6
      Related
      ENSMUSP00000048558.6, ENSMUST00000049251.6
      Conserved Domains (2) summary
      pfam02244
      Location:28 → 100
      Propep_M14; Carboxypeptidase activation peptide
      cl11393
      Location:117 → 418
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      30568368..30592417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321750.1 → XP_017177239.1  carboxypeptidase A4 isoform X1

      Conserved Domains (2) summary
      cd03870
      Location:166 → 467
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:81 → 150
      Propep_M14; Carboxypeptidase activation peptide
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P8K8.2 GenPept UniProtKB/Swiss-Prot:Q6P8K8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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