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    Il1rl1 interleukin 1 receptor-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 17082, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Il1rl1provided by MGI
    Official Full Name
    interleukin 1 receptor-like 1provided by MGI
    Primary source
    MGI:MGI:98427
    See related
    Ensembl:ENSMUSG00000026069 AllianceGenome:MGI:98427
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1
    Summary
    Enables interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including negative regulation of T-helper 1 type immune response; positive regulation of macrophage activation; and regulation of cytokine production. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in external side of plasma membrane and extracellular matrix. Is expressed in several structures, including immune system; musculoskeletal system; salivary gland; skin; and visual system. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14.5 (RPKM 1.3), liver E14 (RPKM 1.3) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Il1rl1 in Genome Data Viewer
    Location:
    1 B; 1 19.19 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40444105..40504575)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40404864..40465418)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor, type I Neighboring gene STARR-positive B cell enhancer ABC_E5749 Neighboring gene STARR-seq mESC enhancer starr_00738 Neighboring gene interleukin 1 receptor-like 2 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00741 Neighboring gene interleukin 18 receptor 1 Neighboring gene interleukin 18 receptor accessory protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF-nuclear IL-33-GATA3 pathway. Akimoto M, et al. Proc Natl Acad Sci U S A, 2023 May 2. PMID 37094129, Free PMC Article
    2. ILC2 require cell-intrinsic ST2 signals to promote type 2 immune responses. Topczewska PM, et al. Front Immunol, 2023. PMID 37063913, Free PMC Article
    3. ST2 and the alteration of cobalt, sodium, potassium and calcium concentration in acute inflammation. Stankovic MS, et al. Exp Mol Pathol, 2022 Oct. PMID 35908617
    4. A rapid and quantitative detection method for plasma soluble growth stimulating gene protein 2 based on time resolved fluorescence immunochromatography. Jing X, et al. Anal Methods, 2022 Jun 9. PMID 35608240
    5. IL-33/ST2 Axis Protects Against Traumatic Brain Injury Through Enhancing the Function of Regulatory T Cells. Xie D, et al. Front Immunol, 2022. PMID 35432343, Free PMC Article

    See all (346) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis.
      Title: The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis.
    2. Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis.
      Title: Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis.
    3. Detrimental impact of the IL-33/ST2 axis in an animal infection model with Cryptococcus neoformans.
      Title: Detrimental impact of the IL-33/ST2 axis in an animal infection model with Cryptococcus neoformans.
    4. The Role of the IL-33/ST2 Axis in CpG-Induced Macrophage Activation Syndrome.
      Title: The Role of the IL-33/ST2 Axis in CpG-Induced Macrophage Activation Syndrome.
    5. THE IL-33/ST2 AXIS PROMOTES ACUTE RESPIRATORY DISTRESS SYNDROME BY NATURAL KILLER T CELLS.
      Title: THE IL-33/ST2 AXIS PROMOTES ACUTE RESPIRATORY DISTRESS SYNDROME BY NATURAL KILLER T CELLS.
    6. Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF-nuclear IL-33-GATA3 pathway.
      Title: Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF-nuclear IL-33-GATA3 pathway.
    7. ILC2 require cell-intrinsic ST2 signals to promote type 2 immune responses.
      Title: ILC2 require cell-intrinsic ST2 signals to promote type 2 immune responses.
    8. The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis.
      Title: The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis.
    9. A comparative study of IL-33 and its receptor ST2 in a C57BL/6 J mouse model of pulmonary Cryptococcus neoformans infection.
      Title: A comparative study of IL-33 and its receptor ST2 in a C57BL/6 J mouse model of pulmonary Cryptococcus neoformans infection.
    10. Setd2 supports GATA3[+]ST2[+] thymic-derived Treg cells and suppresses intestinal inflammation.
      Title: Setd2 supports GATA3(+)ST2(+) thymic-derived Treg cells and suppresses intestinal inflammation.
    Submit: New GeneRIF Correction See all GeneRIFs (154)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (8)  1 citation
    • Endonuclease-mediated (12) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-1 receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-33 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-33 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables interleukin-33 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interleukin-33-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of T-helper 1 type immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type II interferon production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of chemokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-5 production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-1 receptor-like 1
    Names
    interleukin-33 receptor alpha chain
    lymphocyte antigen 84
    NP_001020773.1
    NP_001281100.1
    NP_001407277.1
    NP_001407278.1
    NP_001407279.1
    NP_001407280.1
    NP_034873.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025602.4 → NP_001020773.1  interleukin-1 receptor-like 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001020773.1

      Status: VALIDATED

      Source sequence(s)
      AC167126, AC167168
      Consensus CDS
      CCDS35548.1
      UniProtKB/Swiss-Prot
      P14719, Q05208
      UniProtKB/TrEMBL
      Q3UM53
      Related
      ENSMUSP00000095379.4, ENSMUST00000097772.10
      Conserved Domains (4) summary
      pfam01582
      Location:385 → 540
      TIR; TIR domain
      cd00096
      Location:37 → 42
      Ig; Ig strand B [structural motif]
      cd05757
      Location:124 → 210
      Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
      cl11960
      Location:33 → 97
      Ig; Immunoglobulin domain

    2. NM_001294171.2 → NP_001281100.1  interleukin-1 receptor-like 1 isoform b precursor

      See identical proteins and their annotated locations for NP_001281100.1

      Status: VALIDATED

      Source sequence(s)
      AC167126, AC167168
      Consensus CDS
      CCDS56626.1
      UniProtKB/TrEMBL
      Q5D095
      Related
      ENSMUSP00000134351.2, ENSMUST00000174335.8
      Conserved Domains (3) summary
      cd05757
      Location:124 → 210
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00410
      Location:27 → 110
      IG_like; Immunoglobulin like
      cl11960
      Location:27 → 110
      Ig; Immunoglobulin domain

    3. NM_001420348.1 → NP_001407277.1  interleukin-1 receptor-like 1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC167126, AC167168
      UniProtKB/Swiss-Prot
      P14719, Q05208

    4. NM_001420349.1 → NP_001407278.1  interleukin-1 receptor-like 1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC167126, AC167168
      UniProtKB/Swiss-Prot
      P14719, Q05208

    5. NM_001420350.1 → NP_001407279.1  interleukin-1 receptor-like 1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC167126, AC167168
      UniProtKB/Swiss-Prot
      P14719, Q05208

    6. NM_001420351.1 → NP_001407280.1  interleukin-1 receptor-like 1 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC167126, AC167168

    7. NM_010743.4 → NP_034873.2  interleukin-1 receptor-like 1 isoform b precursor

      See identical proteins and their annotated locations for NP_034873.2

      Status: VALIDATED

      Source sequence(s)
      AC167126, AC167168
      Consensus CDS
      CCDS56626.1
      UniProtKB/TrEMBL
      Q5D095
      Related
      ENSMUSP00000133784.2, ENSMUST00000173514.8
      Conserved Domains (3) summary
      cd05757
      Location:124 → 210
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00410
      Location:27 → 110
      IG_like; Immunoglobulin like
      cl11960
      Location:27 → 110
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      40444105..40504575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14719.2 GenPept UniProtKB/Swiss-Prot:P14719

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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