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    ADAM22 ADAM metallopeptidase domain 22 [ Homo sapiens (human) ]

    Gene ID: 53616, updated on 22-Apr-2024

    Summary

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    Official Symbol
    ADAM22provided by HGNC
    Official Full Name
    ADAM metallopeptidase domain 22provided by HGNC
    Primary source
    HGNC:HGNC:201
    See related
    Ensembl:ENSG00000008277 MIM:603709; AllianceGenome:HGNC:201
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MDC2; DEE61; EIEE61; ADAM 22
    Summary
    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
    Expression
    Biased expression in brain (RPKM 9.0), adrenal (RPKM 2.5) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    7q21.12
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (87934251..88202889)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (89184170..89453378)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (87563566..87832204)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene origin of replication in promoter of DBF4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:87505271-87505780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26234 Neighboring gene uncharacterized LOC124901690 Neighboring gene DBF4-CDC7 kinase regulatory subunit Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:87556085-87556653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:87563985-87564562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:87564563-87565140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:87584727-87585228 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:87663457-87663957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26239 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26240 Neighboring gene uncharacterized LOC105375386 Neighboring gene MPRA-validated peak6626 silencer Neighboring gene uncharacterized LOC124901691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18356 Neighboring gene Sharpr-MPRA regulatory region 10982 Neighboring gene SRI antisense RNA 1 Neighboring gene sorcin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy. van der Knoop MM, et al. Brain, 2022 Jul 29. PMID 35373813, Free PMC Article
    2. ADAM22 as a prognostic and therapeutic drug target in the treatment of endocrine-resistant breast cancer. Bolger JC, et al. Vitam Horm, 2013. PMID 23810013
    3. Biological characterization of ADAM22 variants reveals the importance of a disintegrin domain sequence in cell surface expression. Sagane K, et al. J Recept Signal Transduct Res, 2010 Apr. PMID 20156119
    4. Expression, purification and insights into structure and folding of the ADAM22 pro domain. Sørensen HP, et al. Protein Expr Purif, 2008 Oct. PMID 18593599
    5. Autosomal dominant lateral temporal epilepsy: absence of mutations in ADAM22 and Kv1 channel genes encoding LGI1-associated proteins. Diani E, et al. Epilepsy Res, 2008 Jul. PMID 18440780

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADAM22 acts as a novel predictive biomarker for unfavorable prognosis and facilitates metastasis via PI3K/AKT signaling pathway in nasopharyngeal carcinoma.
      Title: ADAM22 acts as a novel predictive biomarker for unfavorable prognosis and facilitates metastasis via PI3K/AKT signaling pathway in nasopharyngeal carcinoma.
    2. Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy.
      Title: Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy.
    3. LGI3 is secreted and binds to ADAM22 via TRIF-dependent NF-kappaB pathway in response to LPS in human keratinocytes.
      Title: LGI3 is secreted and binds to ADAM22 via TRIF-dependent NF-κB pathway in response to LPS in human keratinocytes.
    4. ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis.
      Title: ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis.
    5. the LGI1-ADAM22 complex functions as the trans-synaptic machinery for precise synaptic transmission
      Title: Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
    6. ADAM22 is critically involved in miR-449a-reduced tamoxifen resistance of estrogen receptor-positive breast cancer cells as a direct target of miR-449a.
      Title: miR-449a Suppresses Tamoxifen Resistance in Human Breast Cancer Cells by Targeting ADAM22.
    7. these results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE-causing LGI1 mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 with both ADAM22 and ADAM23 play an important role in the molecular mechanisms leading to utosomal dominant lateral temporal epilepsy
      Title: Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 Receptors.
    8. Disruption of LGI1-ADAM22 interaction reduces synaptic AMPA receptors in hippocampal neurons.
      Title: Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors.
    9. Data suggest that ADAM22 plays roles in cell differentiation, cell migration, and resistance to endocrine therapy in breast cancer; ADAM22 may serve as biomarker for poor disease-free survival in breast cancer patients. [REVIEW]
      Title: ADAM22 as a prognostic and therapeutic drug target in the treatment of endocrine-resistant breast cancer.
    10. findings suggest that SRC-1 switches steroid-responsive tumors to a steroid-resistant state in which the SRC-1 target gene ADAM22 has a critical role
      Title: Global characterization of the SRC-1 transcriptome identifies ADAM22 as an ER-independent mediator of endocrine-resistant breast cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Developmental and epileptic encephalopathy, 61
    MedGen: C4693688 OMIM: 617933 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study of serious blistering skin rash caused by drugs.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC149832

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables integrin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 22
    Names
    a disintegrin and metalloproteinase domain 22
    metalloproteinase-disintegrin ADAM22-3
    metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324417.2 → NP_001311346.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) encodes isoform 6. The encoded isoform (6) may undergo proteolytic processing.
      Source sequence(s)
      AC004992, AC005075, AC005164, DR000609, R41888
      UniProtKB/TrEMBL
      Q08AL8

    2. NM_001324418.2 → NP_001311347.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 7 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes isoform 7. The encoded isoform (7) may undergo proteolytic processing.
      Source sequence(s)
      AC004992, AC005075, AC005164, DR000609, R41888
      Consensus CDS
      CCDS94137.1
      UniProtKB/TrEMBL
      A0A804HHS1, H7C3I4
      Related
      ENSP00000412085.2, ENST00000413139.2

    3. NM_001324419.2 → NP_001311348.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 8 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) encodes isoform 8. The encoded isoform (8) may undergo proteolytic processing.
      Source sequence(s)
      AC004992, AC005075, AC005164, DR000609, R41888
      UniProtKB/TrEMBL
      A0A804HHS1

    4. NM_001324420.2 → NP_001311349.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 9 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) encodes isoform 9. The encoded isoform (9) may undergo proteolytic processing.
      Source sequence(s)
      AC004992, AC005075, AC005164, DR000609, R41888
      UniProtKB/TrEMBL
      A0A804HHS1

    5. NM_001324421.2 → NP_001311350.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 10 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) encodes isoform 10. The encoded isoform (10) may undergo proteolytic processing.
      Source sequence(s)
      AC004992, AC005075, AC005164, DR000609, R41888
      UniProtKB/TrEMBL
      Q08AL8

    6. NM_001391975.1 → NP_001378904.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:470 → 545
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:547 → 688
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:256 → 455
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:102 → 205
      Pep_M12B_propep; Reprolysin family propeptide

    7. NM_001391976.1 → NP_001378905.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:453 → 528
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:530 → 671
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:239 → 438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:71 → 188
      Pep_M12B_propep; Reprolysin family propeptide

    8. NM_001391977.1 → NP_001378906.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:453 → 528
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:530 → 671
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:239 → 438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:71 → 188
      Pep_M12B_propep; Reprolysin family propeptide

    9. NM_001391978.1 → NP_001378907.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 14 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:452 → 527
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:529 → 670
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:238 → 437
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70 → 187
      Pep_M12B_propep; Reprolysin family propeptide

    10. NM_001391979.1 → NP_001378908.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 15 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:452 → 527
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:529 → 670
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:238 → 437
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70 → 187
      Pep_M12B_propep; Reprolysin family propeptide

    11. NM_001391980.1 → NP_001378909.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 16 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:470 → 545
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:547 → 688
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:256 → 455
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:102 → 205
      Pep_M12B_propep; Reprolysin family propeptide

    12. NM_001391981.1 → NP_001378910.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 17 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:452 → 527
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:529 → 670
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:238 → 437
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70 → 187
      Pep_M12B_propep; Reprolysin family propeptide

    13. NM_001391982.1 → NP_001378911.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 18 precursor

      Status: REVIEWED

      Source sequence(s)
      AC004992, AC005075, AC005164
      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (4) summary
      smart00050
      Location:445 → 520
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:522 → 663
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:241 → 430
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:102 → 205
      Pep_M12B_propep; Reprolysin family propeptide

    14. NM_004194.5 → NP_004185.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 4 precursor

      See identical proteins and their annotated locations for NP_004185.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as beta, uses an alternate splice site in the 3' coding region and lacks two downstream exons, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct C-terminus, compared to isoform 1. The encoded isoform (4) may undergo proteolytic processing.
      Source sequence(s)
      AB009671, AC005075, DR000609
      Consensus CDS
      CCDS43610.1
      UniProtKB/TrEMBL
      A0A804HHS1
      Related
      ENSP00000381260.4, ENST00000398201.8
      Conserved Domains (5) summary
      smart00608
      Location:530 → 671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239 → 436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453 → 527
      Disintegrin; Disintegrin
      pfam01421
      Location:239 → 438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75 → 187
      Pep_M12B_propep; Reprolysin family propeptide

    15. NM_016351.6 → NP_057435.2  disintegrin and metalloproteinase domain-containing protein 22 isoform 3 precursor

      See identical proteins and their annotated locations for NP_057435.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as alpha, lacks an in-frame exon compared to variant 1. The encoded isoform (3) is shorter than isoform 1. The encoded isoform (3) may undergo proteolytic processing.
      Source sequence(s)
      AC005075, AC005164, AK291010, DR000609, R41888
      Consensus CDS
      CCDS43609.1
      UniProtKB/TrEMBL
      Q08AL8
      Related
      ENSP00000381262.4, ENST00000398204.8
      Conserved Domains (5) summary
      smart00608
      Location:530 → 671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239 → 436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453 → 527
      Disintegrin; Disintegrin
      pfam01421
      Location:239 → 438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75 → 187
      Pep_M12B_propep; Reprolysin family propeptide

    16. NM_021721.5 → NP_068367.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 5 precursor

      See identical proteins and their annotated locations for NP_068367.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region and lacks one coding and two non-coding exons, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus, compared to isoform 1. The encoded isoform (5) may undergo proteolytic processing.
      Source sequence(s)
      AB009671, AC005075, AF155381, DR000609
      Consensus CDS
      CCDS94138.1
      UniProtKB/TrEMBL
      Q08AL8
      Related
      ENSP00000508320.1, ENST00000684002.1
      Conserved Domains (5) summary
      smart00608
      Location:530 → 671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239 → 436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453 → 527
      Disintegrin; Disintegrin
      pfam01421
      Location:239 → 438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75 → 187
      Pep_M12B_propep; Reprolysin family propeptide

    17. NM_021722.6 → NP_068368.2  disintegrin and metalloproteinase domain-containing protein 22 isoform 2 precursor

      See identical proteins and their annotated locations for NP_068368.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as delta, has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. The encoded isoform (2) may undergo proteolytic processing.
      Source sequence(s)
      AC005075, AF155381, DR000609, R41888
      Consensus CDS
      CCDS43608.1
      UniProtKB/TrEMBL
      Q08AL8
      Related
      ENSP00000381267.3, ENST00000398209.7
      Conserved Domains (5) summary
      smart00608
      Location:530 → 671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239 → 436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453 → 527
      Disintegrin; Disintegrin
      pfam01421
      Location:239 → 438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75 → 187
      Pep_M12B_propep; Reprolysin family propeptide

    18. NM_021723.5 → NP_068369.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_068369.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as epsilon, encodes isoform 1, which is proteolytically processed to generate the mature protein.
      Source sequence(s)
      AC005075, AF155382, DR000609, R41888
      Consensus CDS
      CCDS47637.1
      UniProtKB/Swiss-Prot
      O75075, O75076, Q9P0K1, Q9P0K2, Q9UIA1, Q9UKK2
      UniProtKB/TrEMBL
      Q08AL8
      Related
      ENSP00000265727.7, ENST00000265727.11
      Conserved Domains (5) summary
      smart00608
      Location:530 → 671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239 → 436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453 → 527
      Disintegrin; Disintegrin
      pfam01421
      Location:239 → 438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75 → 187
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      87934251..88202889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012330.3 → XP_016867819.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X9

      UniProtKB/TrEMBL
      A0A804HHS1

    2. XM_017012335.3 → XP_016867824.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X14

      UniProtKB/TrEMBL
      Q08AL8

    3. XM_011516318.3 → XP_011514620.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

      UniProtKB/TrEMBL
      A0A804HHS1
      Conserved Domains (5) summary
      smart00608
      Location:530 → 671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239 → 436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453 → 527
      Disintegrin; Disintegrin
      pfam01421
      Location:239 → 438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75 → 187
      Pep_M12B_propep; Reprolysin family propeptide

    4. XM_011516322.3 → XP_011514624.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X7

      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (5) summary
      smart00608
      Location:530 → 671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239 → 436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453 → 527
      Disintegrin; Disintegrin
      pfam01421
      Location:239 → 438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75 → 187
      Pep_M12B_propep; Reprolysin family propeptide

    5. XM_017012332.3 → XP_016867821.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X11

      UniProtKB/TrEMBL
      Q08AL8

    6. XM_017012333.3 → XP_016867822.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X13

      UniProtKB/TrEMBL
      A0A804HHS1

    7. XM_011516323.3 → XP_011514625.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X10

      UniProtKB/TrEMBL
      Q08AL8
      Conserved Domains (5) summary
      smart00608
      Location:530 → 671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239 → 436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453 → 527
      Disintegrin; Disintegrin
      pfam01421
      Location:239 → 438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75 → 187
      Pep_M12B_propep; Reprolysin family propeptide

    8. XM_011516319.4 → XP_011514621.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

      UniProtKB/TrEMBL
      A0A804HHS1
      Conserved Domains (5) summary
      smart00608
      Location:529 → 670
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:238 → 435
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:452 → 526
      Disintegrin; Disintegrin
      pfam01421
      Location:238 → 437
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:74 → 186
      Pep_M12B_propep; Reprolysin family propeptide

    9. XM_006716028.5 → XP_006716091.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

      UniProtKB/TrEMBL
      B3KWN4
      Conserved Domains (5) summary
      smart00608
      Location:582 → 723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:291 → 488
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:505 → 579
      Disintegrin; Disintegrin
      pfam01421
      Location:291 → 490
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:127 → 239
      Pep_M12B_propep; Reprolysin family propeptide

    10. XM_011516320.4 → XP_011514622.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

      UniProtKB/TrEMBL
      B3KWN4
      Conserved Domains (5) summary
      smart00608
      Location:582 → 723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:291 → 488
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:505 → 579
      Disintegrin; Disintegrin
      pfam01421
      Location:291 → 490
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:127 → 239
      Pep_M12B_propep; Reprolysin family propeptide

    11. XM_011516321.4 → XP_011514623.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

      UniProtKB/TrEMBL
      B3KWN4
      Conserved Domains (5) summary
      smart00608
      Location:582 → 723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:291 → 488
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:505 → 579
      Disintegrin; Disintegrin
      pfam01421
      Location:291 → 490
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:127 → 239
      Pep_M12B_propep; Reprolysin family propeptide

    12. XM_005250445.5 → XP_005250502.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X8

      UniProtKB/TrEMBL
      B3KWN4
      Conserved Domains (5) summary
      smart00608
      Location:582 → 723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:291 → 488
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:505 → 579
      Disintegrin; Disintegrin
      pfam01421
      Location:291 → 490
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:127 → 239
      Pep_M12B_propep; Reprolysin family propeptide

    13. XM_006716029.5 → XP_006716092.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X6

      UniProtKB/TrEMBL
      B3KWN4
      Conserved Domains (5) summary
      smart00608
      Location:582 → 723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:291 → 488
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:505 → 579
      Disintegrin; Disintegrin
      pfam01421
      Location:291 → 490
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:127 → 239
      Pep_M12B_propep; Reprolysin family propeptide

    14. XM_011516324.3 → XP_011514626.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X12

      UniProtKB/TrEMBL
      A0A804HHS1
      Conserved Domains (5) summary
      smart00608
      Location:456 → 597
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:165 → 362
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:379 → 453
      Disintegrin; Disintegrin
      pfam01421
      Location:165 → 364
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:8 → 113
      Pep_M12B_propep; Reprolysin family propeptide

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      89184170..89453378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358425.1 → XP_054214400.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X9

    2. XM_054358430.1 → XP_054214405.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X14

    3. XM_054358418.1 → XP_054214393.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

    4. XM_054358423.1 → XP_054214398.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X7

    5. XM_054358427.1 → XP_054214402.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X11

    6. XM_054358429.1 → XP_054214404.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X13

    7. XM_054358426.1 → XP_054214401.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X10

    8. XM_054358419.1 → XP_054214394.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

    9. XM_054358417.1 → XP_054214392.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

    10. XM_054358420.1 → XP_054214395.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

    11. XM_054358421.1 → XP_054214396.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

    12. XM_054358424.1 → XP_054214399.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X8

    13. XM_054358422.1 → XP_054214397.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X6

    14. XM_054358428.1 → XP_054214403.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X12

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P0K1.1 GenPept UniProtKB/Swiss-Prot:Q9P0K1

    Gene LinkOut

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