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    CCDC25 coiled-coil domain containing 25 [ Homo sapiens (human) ]

    Gene ID: 55246, updated on 10-Mar-2024

    Summary

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    Official Symbol
    CCDC25provided by HGNC
    Official Full Name
    coiled-coil domain containing 25provided by HGNC
    Primary source
    HGNC:HGNC:25591
    See related
    Ensembl:ENSG00000147419 MIM:619100; AllianceGenome:HGNC:25591
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables DNA binding activity. Involved in positive regulation of cell motility. Located in endomembrane system. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum (RPKM 17.8), small intestine (RPKM 15.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CCDC25 in Genome Data Viewer
    Location:
    8p21.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (27733316..27772640, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (28010681..28050010, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27590833..27630157, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene scavenger receptor class A member 3 Neighboring gene uncharacterized LOC124901921 Neighboring gene uncharacterized LOC124901920 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:27560651-27560796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:27562294-27562794 Neighboring gene microRNA 3622b Neighboring gene microRNA 3622a Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27154 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27587170-27587710 Neighboring gene uncharacterized LOC107986934 Neighboring gene uncharacterized LOC124902093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19051 Neighboring gene RNA, U6 small nuclear 1276, pseudogene Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene MPRA-validated peak6971 silencer Neighboring gene PDZ binding kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation. Tang Q, et al. Sci Rep, 2022 Oct 17. PMID 36253427, Free PMC Article
    2. High expression of CCDC25 in cholangiocarcinoma tissue samples. Proungvitaya S, et al. Oncol Lett, 2017 Aug. PMID 28789463, Free PMC Article
    3. Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis. Siriphak S, et al. Molecules, 2021 May 22. PMID 34067437, Free PMC Article
    4. CCDC25: precise navigator for neutrophil extracellular traps on the prometastatic road. Liu R, et al. Signal Transduct Target Ther, 2020 Aug 24. PMID 32839429, Free PMC Article
    5. DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25. Yang L, et al. Nature, 2020 Jul. PMID 32528174

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Serum CCDC25 Levels as a Potential Marker for Metabolic Syndrome.
      Title: Serum CCDC25 Levels as a Potential Marker for Metabolic Syndrome.
    2. Coiled-coil domain containing 25 (CCDC25) regulates cell proliferation, migration, and invasion in clear cell renal cell carcinoma by targeting the ILK-NF-kappaB signaling pathway.
      Title: Coiled-coil domain containing 25 (CCDC25) regulates cell proliferation, migration, and invasion in clear cell renal cell carcinoma by targeting the ILK-NF-κB signaling pathway.
    3. Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation.
      Title: Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation.
    4. CCDC25: precise navigator for neutrophil extracellular traps on the prometastatic road.
      Title: CCDC25: precise navigator for neutrophil extracellular traps on the prometastatic road.
    5. Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis.
      Title: Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis.
    6. DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.
      Title: DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10853

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of cell motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304529.2 → NP_001291458.1  coiled-coil domain-containing protein 25 isoform 2

      See identical proteins and their annotated locations for NP_001291458.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive exons in the coding region which results in a frame shift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC013643, AC104997, BC065295, BU602778
      Consensus CDS
      CCDS78324.1
      UniProtKB/TrEMBL
      G3V121
      Related
      ENSP00000429861.1, ENST00000524084.5
      Conserved Domains (1) summary
      pfam05670
      Location:12 → 82
      DUF814; Domain of unknown function (DUF814)

    2. NM_001304530.2 → NP_001291459.1  coiled-coil domain-containing protein 25 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons in the coding region compared to variant 1. These difference result in the uses a downstream start codon and frameshift in the 3' coding region compared to variant 1. The encoded isoform (3) has a shorter N-terminus and a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC013643, AC104997, BC065295, BG718771
      UniProtKB/Swiss-Prot
      Q86WR0
      Conserved Domains (1) summary
      pfam05670
      Location:1 → 32
      DUF814; Domain of unknown function (DUF814)

    3. NM_001304532.2 → NP_001291461.1  coiled-coil domain-containing protein 25 isoform 4

      See identical proteins and their annotated locations for NP_001291461.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an exon in the 5' UTR which results in the use of a downstream start codon compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC013643, AK001715, BC065295
      Consensus CDS
      CCDS78323.1
      UniProtKB/Swiss-Prot
      Q86WR0
      Related
      ENSP00000428000.1, ENST00000522915.5
      Conserved Domains (1) summary
      cl05307
      Location:1 → 44
      DUF814; Domain of unknown function (DUF814)

    4. NM_018246.3 → NP_060716.2  coiled-coil domain-containing protein 25 isoform 1

      See identical proteins and their annotated locations for NP_060716.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC013643, BC065295, DA218015
      Consensus CDS
      CCDS6062.2
      UniProtKB/Swiss-Prot
      Q0P663, Q86WR0, Q96SI2, Q9NV98
      UniProtKB/TrEMBL
      Q7Z5U5
      Related
      ENSP00000348933.4, ENST00000356537.9
      Conserved Domains (1) summary
      pfam05670
      Location:1 → 112
      DUF814; Domain of unknown function (DUF814)

    RNA

    1. NR_130761.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC013643, AC104997, AK316015, BC065295

    2. NR_130762.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC013643, AK001715, BC065295, BC110391
      Related
      ENST00000520486.5

    3. NR_156432.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC013643, BC065295, DC307301

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      27733316..27772640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544571.3 → XP_011542873.1  coiled-coil domain-containing protein 25 isoform X1

      See identical proteins and their annotated locations for XP_011542873.1

      UniProtKB/Swiss-Prot
      Q86WR0
      Conserved Domains (1) summary
      cl05307
      Location:1 → 44
      DUF814; Domain of unknown function (DUF814)

    2. XM_011544570.3 → XP_011542872.1  coiled-coil domain-containing protein 25 isoform X1

      See identical proteins and their annotated locations for XP_011542872.1

      UniProtKB/Swiss-Prot
      Q86WR0
      Conserved Domains (1) summary
      cl05307
      Location:1 → 44
      DUF814; Domain of unknown function (DUF814)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      28010681..28050010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360767.1 → XP_054216742.1  coiled-coil domain-containing protein 25 isoform X1

    2. XM_054360766.1 → XP_054216741.1  coiled-coil domain-containing protein 25 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86WR0.2 GenPept UniProtKB/Swiss-Prot:Q86WR0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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