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    CCDC25 coiled-coil domain containing 25 [ Homo sapiens (human) ]

    Gene ID: 55246, updated on 17-Oct-2021

    Summary

    Official Symbol
    CCDC25provided by HGNC
    Official Full Name
    coiled-coil domain containing 25provided by HGNC
    Primary source
    HGNC:HGNC:25591
    See related
    Ensembl:ENSG00000147419 MIM:619100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in duodenum (RPKM 17.8), small intestine (RPKM 15.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CCDC25 in Genome Data Viewer
    Location:
    8p21.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (27733316..27772640, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27590833..27630157, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene scavenger receptor class A member 3 Neighboring gene RNA, U6 small nuclear 1086, pseudogene Neighboring gene microRNA 3622b Neighboring gene microRNA 3622a Neighboring gene uncharacterized LOC107986934 Neighboring gene RNA, U6 small nuclear 1276, pseudogene Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene PDZ binding kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10853

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of cell motility IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    coiled-coil domain-containing protein 25

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304529.2NP_001291458.1  coiled-coil domain-containing protein 25 isoform 2

      See identical proteins and their annotated locations for NP_001291458.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive exons in the coding region which results in a frame shift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC013643, AC104997, BC065295, BU602778
      Consensus CDS
      CCDS78324.1
      UniProtKB/Swiss-Prot
      Q86WR0
      UniProtKB/TrEMBL
      G3V121
      Related
      ENSP00000429861.1, ENST00000524084.5
      Conserved Domains (1) summary
      pfam05670
      Location:1282
      DUF814; Domain of unknown function (DUF814)
    2. NM_001304530.2NP_001291459.1  coiled-coil domain-containing protein 25 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons in the coding region compared to variant 1. These difference result in the uses a downstream start codon and frameshift in the 3' coding region compared to variant 1. The encoded isoform (3) has a shorter N-terminus and a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC013643, AC104997, BC065295, BG718771
      UniProtKB/Swiss-Prot
      Q86WR0
      Conserved Domains (1) summary
      pfam05670
      Location:132
      DUF814; Domain of unknown function (DUF814)
    3. NM_001304532.2NP_001291461.1  coiled-coil domain-containing protein 25 isoform 4

      See identical proteins and their annotated locations for NP_001291461.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an exon in the 5' UTR which results in the use of a downstream start codon compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC013643, AK001715, BC065295
      Consensus CDS
      CCDS78323.1
      UniProtKB/Swiss-Prot
      Q86WR0
      Related
      ENSP00000428000.1, ENST00000522915.5
      Conserved Domains (1) summary
      cl05307
      Location:144
      DUF814; Domain of unknown function (DUF814)
    4. NM_018246.3NP_060716.2  coiled-coil domain-containing protein 25 isoform 1

      See identical proteins and their annotated locations for NP_060716.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC013643, BC065295, DA218015
      Consensus CDS
      CCDS6062.2
      UniProtKB/Swiss-Prot
      Q86WR0
      Related
      ENSP00000348933.4, ENST00000356537.9
      Conserved Domains (1) summary
      pfam05670
      Location:1112
      DUF814; Domain of unknown function (DUF814)

    RNA

    1. NR_130761.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC013643, AC104997, AK316015, BC065295
    2. NR_130762.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC013643, AK001715, BC065295, BC110391
      Related
      ENST00000520486.5
    3. NR_156432.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC013643, BC065295, DC307301

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      27733316..27772640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544570.2XP_011542872.1  coiled-coil domain-containing protein 25 isoform X1

      See identical proteins and their annotated locations for XP_011542872.1

      UniProtKB/Swiss-Prot
      Q86WR0
      Conserved Domains (1) summary
      cl05307
      Location:144
      DUF814; Domain of unknown function (DUF814)
    2. XM_011544571.2XP_011542873.1  coiled-coil domain-containing protein 25 isoform X1

      See identical proteins and their annotated locations for XP_011542873.1

      UniProtKB/Swiss-Prot
      Q86WR0
      Conserved Domains (1) summary
      cl05307
      Location:144
      DUF814; Domain of unknown function (DUF814)
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