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    PBK PDZ binding kinase [ Homo sapiens (human) ]

    Gene ID: 55872, updated on 26-Sep-2021

    Summary

    Official Symbol
    PBKprovided by HGNC
    Official Full Name
    PDZ binding kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:18282
    See related
    Ensembl:ENSG00000168078 MIM:611210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPK; CT84; TOPK; HEL164; Nori-3
    Summary
    This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Expression
    Biased expression in testis (RPKM 35.2), lymph node (RPKM 5.8) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PBK in Genome Data Viewer
    Location:
    8p21.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (27809624..27837817, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27667141..27695334, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986934 Neighboring gene coiled-coil domain containing 25 Neighboring gene RNA, U6 small nuclear 1276, pseudogene Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa pseudogene Neighboring gene SCARA5 intron CAGE-defined high expression enhancer Neighboring gene scavenger receptor class A member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ14385

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of stress-activated MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    lymphokine-activated killer T-cell-originated protein kinase
    Names
    MAPKK-like protein kinase
    T-LAK cell-originated protein kinase
    cancer/testis antigen 84
    epididymis luminal protein 164
    serine/threonine protein kinase
    spermatogenesis-related protein kinase
    NP_001265874.1
    NP_001349969.1
    NP_060962.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278945.2NP_001265874.1  lymphokine-activated killer T-cell-originated protein kinase isoform 2

      See identical proteins and their annotated locations for NP_001265874.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is longer, compared to isoform 1.
      Source sequence(s)
      AK301836, BC015191, DB028500
      Consensus CDS
      CCDS64858.1
      UniProtKB/Swiss-Prot
      Q96KB5
      Related
      ENSP00000428489.1, ENST00000522944.5
      Conserved Domains (2) summary
      cd14001
      Location:32332
      PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase
      pfam00069
      Location:34327
      Pkinase; Protein kinase domain
    2. NM_001363040.2NP_001349969.1  lymphokine-activated killer T-cell-originated protein kinase isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      BC015191, DC395891
      Consensus CDS
      CCDS6063.1
      Conserved Domains (1) summary
      cd14001
      Location:32321
      PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase
    3. NM_018492.4NP_060962.2  lymphokine-activated killer T-cell-originated protein kinase isoform 1

      See identical proteins and their annotated locations for NP_060962.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript, and encodes the shorter isoform (1). Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      BC015191, DB028500
      Consensus CDS
      CCDS6063.1
      UniProtKB/Swiss-Prot
      Q96KB5
      UniProtKB/TrEMBL
      V9HWH0
      Related
      ENSP00000301905.4, ENST00000301905.9
      Conserved Domains (1) summary
      cd14001
      Location:32321
      PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      27809624..27837817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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